公开(公告)号：EP3787615A1

公开(公告)日：2021-03-10

申请号：EP19721270.7

申请日：2019-04-30

申请人： Amazentis SA

发明人： RINSCH, Christopher ,  SINGH, Anurag ,  D'AMICO, Davide ,  ANDREUX, Pénélope ,  BLANCO-BOSE, William

IPC分类号： A61K31/335 ,  A61K39/00 ,  A61K39/12

公开(公告)号：EP3592425A1

公开(公告)日：2020-01-15

申请号：EP18712107.4

申请日：2018-03-08

申请人： Amazentis SA

发明人： RINSCH, Christopher ,  ANDREUX, Penelope ,  SINGH, Anurag

IPC分类号： A61P3/00 ,  C07D311/80 ,  A61K31/366

公开(公告)号：EP3592424A1

公开(公告)日：2020-01-15

申请号：EP18712106.6

申请日：2018-03-08

申请人： Amazentis SA

发明人： RINSCH, Christopher ,  ANDREUX, Penelope ,  SINGH, Anurag

IPC分类号： A61P3/00 ,  A61K31/366 ,  C07D311/80

公开(公告)号：EP3369420A1

公开(公告)日：2018-09-05

申请号：EP18166897.1

申请日：2011-12-23

申请人： Amazentis SA

发明人： RINSCH, Christopher ,  ANDREUX, Penelope ,  SCHNEIDER, Bernard ,  SANDI, Carmen ,  AUWERX, Johan ,  PIRINEN, Eija ,  THOMAS, Charles ,  HOUTKOOPER, Richardus ,  BLANCO-BOSE, William ,  MOUCHIROUD, Laurent ,  GENOUX, David

IPC分类号： A61K31/352 ,  A61K36/00 ,  A61K36/185 ,  A23L33/105

CPC分类号： A61K31/366 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0056 ,  A61K31/352 ,  A61K31/7048 ,  A61K36/185 ,  Y02A50/401

摘要： Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

公开(公告)号：EP4424368A2

公开(公告)日：2024-09-04

申请号：EP24184350.7

申请日：2016-08-26

申请人： Amazentis SA

发明人： ANDREAUX, Penelope ,  RINSCH, Christopher ,  BLANCO-BOSE, William

IPC分类号： A61P25/00

CPC分类号： A61K38/01 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/08 ,  A61K47/42 ,  A61K9/146 ,  A61K31/37 ,  A23L2/66 ,  A23V2002/0020130101 ,  A23L33/40 ,  A23L33/105 ,  A23L33/19 ,  A23L2/52 ,  C07D311/80 ,  A61P21/00 ,  A61P25/00 ,  A61K38/018 ,  A61K38/1709

摘要： The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.

公开(公告)号：EP3592347A1

公开(公告)日：2020-01-15

申请号：EP18714139.5

申请日：2018-03-08

申请人： Amazentis SA

发明人： RINSCH, Christopher ,  ANDREUX, Penelope ,  SINGH, Anurag

IPC分类号： A61K31/366 ,  A61K9/00 ,  A61K47/00 ,  A61P17/02 ,  A61P17/16 ,  A61P17/04 ,  A61P17/12 ,  A61P17/06 ,  A61P17/18 ,  A61P17/00

公开(公告)号：EP3393467A1

公开(公告)日：2018-10-31

申请号：EP16819114.6

申请日：2016-12-23

申请人： Amazentis SA

发明人： ANDREUX, Penelope ,  RINSCH, Christopher

IPC分类号： A61K31/366 ,  A61K31/706 ,  A23L29/00

CPC分类号： A61K31/366 ,  A23L29/00 ,  A61K31/706 ,  A61K2300/00

摘要： A composition comprising: a)nicotinamide riboside and b)a urolithin which is a compound of formula (I) or a salt thereof: Formula (I) wherein: A, B, C and D are each independently selected from H and OH; W, X and Y are each independently selected from H and OH; and Z is selected from H and OH. The compositions are useful as medicaments, for example for treating muscle-related pathological conditions, neurodegenerative diseases, and/or mitochondrial diseases and as dietary supplements, functional foods and beverages, and specialised nutrition or medical foods.

公开(公告)号：EP4017487A1

公开(公告)日：2022-06-29

申请号：EP20756907.0

申请日：2020-08-20

申请人： Amazentis SA

发明人： RINSCH, Christopher ,  GRETEN, Florian ,  DRACHSLER, Moritz ,  ZIEGLER, Paul

IPC分类号： A61K31/37 ,  A61K45/06 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28

公开(公告)号：EP3278800A3

公开(公告)日：2018-03-07

申请号：EP17186188.3

申请日：2011-12-23

申请人： Amazentis SA

发明人： ANDREUX, Penelope ,  SCHNEIDER, Bernard ,  RINSCH, Christopher ,  SANDI, Carmen ,  AUWERX, Johan ,  PIRINEN, Eija ,  THOMAS, Charles ,  HOUTKOOPER, Richardus ,  BLANCO-BOSE, William ,  MOUCHIROUD, Laurent ,  GENOUX, David

IPC分类号： A61K31/352 ,  A61K36/00 ,  A61K36/185

CPC分类号： A61K31/366 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0056 ,  A61K31/352 ,  A61K31/7048 ,  A61K36/185 ,  Y02A50/401

摘要： Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

公开(公告)号：EP3278800A2

公开(公告)日：2018-02-07

申请号：EP17186188.3

申请日：2011-12-23

申请人： Amazentis SA

发明人： ANDREUX, Penelope ,  SCHNEIDER, Bernard ,  RINSCH, Christopher ,  SANDI, Carmen ,  AUWERX, Johan ,  PIRINEN, Eija ,  THOMAS, Charles ,  HOUTKOOPER, Richardus ,  BLANCO-BOSE, William ,  MOUCHIROUD, Laurent ,  GENOUX, David

IPC分类号： A61K31/352 ,  A61K36/00 ,  A61K36/185

CPC分类号： A61K31/366 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0056 ,  A61K31/352 ,  A61K31/7048 ,  A61K36/185 ,  Y02A50/401

摘要： Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and/or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

摘要翻译： 提供了包含可用于多种治疗应用的化合物或化合物前体的组合物，所述治疗应用包括例如治疗和/或预防与线粒体活性降低或不足相关的疾病或病症，包括衰老或压力，糖尿病，肥胖症， 和神经退行性疾病。 所述化合物通常涉及尿石素及其前体，包括但不限于鞣花单宁和尿石素A.在某些实施方案中，所述组合物呈现为食物产品或营养增补剂或作为食物产品或营养增补剂存在。 这些相同的化合物和组合物还可有利地用于一般健康个体，以增加或维持代谢率，降低体脂百分比，增加或维持肌肉质量，控制体重，改善或维持精神表现（包括记忆），改善或维持肌肉 表现，改善或保持情绪，并管理压力。