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    Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them
    2.
    发明公开
    Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them 失效
    4-取代氮杂环丁酮作为前体2-取代-3-羧酸碳青霉烯类抗生素和它们的制备的方法。

    公开(公告)号：EP0504612A2

    公开(公告)日：1992-09-23

    申请号：EP92102925.2

    申请日：1992-02-21

    申请人： AMERICAN CYANAMID COMPANY

    发明人： Feigelson, Gregg Brian ,  Curran, William V. ,  Ziegler, Carl Bernard

    IPC分类号： C07D205/08 ,  C07F7/18 ,  C07D477/00 ,  C07D463/00

    CPC分类号： C07D477/04 ,  C07D205/08 ,  C07F7/1856 ,  C07F7/186 ,  C07F9/568

    摘要： 4-substituted azetidinones having the formulae I and II:

    with R¹, R², R³, R⁴, R⁵ and X defined hereafter, which are intermediates for the preparation of carbapenem and carbacephem antibacterials and processes for producing such antibacterials through the utilization of an acid mediated ring closure reaction. R¹is hydrogen, hydroxy (lower) alkyl or protected hydroxy (lower) alkyl; R²is selected from the group consisting of hydrogen and (C₁-C₆) alkyl; R³is hydrogen, or an organic group; R⁴is hydrogen or a suitable removable protecting group for an amide nitrogen; R⁵is hydrogen or a suitable removable protecting group for a carboxylic acid; Xis oxygen, sulfur, a moiety of the formula NR⁶.

    摘要翻译： 具有式餐饮I和II的新4- substituiertem氮杂环丁酮：其中R <1>，R <2> [R <3>，R <4> - [R <5>和X定义见下文，这是中间体 制备碳青霉烯和头孢烯抗菌和过程用于通过酸传递闭环反应的利用率寻求生产抗菌药。