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公开(公告)号：EP2277543B1
公开(公告)日：2015-12-16
申请号：EP10010884.4
申请日：2003-09-05
发明人： Huang, Haichun , Varnum, Brian , Vezina, Chris , Witte, Alison , Qian, Xueming , Martin, Frank , Elliott, Gary
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
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公开(公告)号：EP2277543A1
公开(公告)日：2011-01-26
申请号：EP10010884.4
申请日：2003-09-05
申请人： Amgen, Inc , Medarex, Inc.
发明人： Huang, Haichun , Varnum, Brian , Vezina, Chris , Witte, Alison , Qian, Xueming , Martin, Frank , Elliott, Gary
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1 R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.
摘要翻译： 描述了与白细胞介素-1受体1型（IL-1R1）相互作用的抗体。 描述了通过向IL-1 R1施用药学有效量的抗体来治疗IL-1介导的疾病的方法。 描述了使用IL-1R1抗体检测样品中IL-1R1的量的方法。
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3.发明公开Human anti-NGF neutralizing antibodies as selective NGF pathway inhibitors 审中-公开Menschliche抗NGF-neutralisierendeAntikörperALS selektive NGF-Pfadhemmer
公开(公告)号：EP2364728A1
公开(公告)日：2011-09-14
申请号：EP10011652.4
申请日：2004-07-15
申请人： Amgen, Inc , Medarex, Inc.
发明人： Wild, Kenneth D., Jr. , Treanor, James J.,S. , Huang, Haichun , Inoue, Heather , Zhang, Tie, J. , Martin, Frank
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/48 , G01N2800/2842
摘要： This invention provides antibodies that interact with or bind to human nerve growth factor (NGF) and neutralize the function of NGF thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing NGF function, and particularly for treating NGF-related disorders (e.g., chronic pain) by administering a pharmaceutically effective amount of anti-NGF antibodies. Methods of detecting the amount of NGF in a sample using anti-NGF antibodies are also provided.
摘要翻译： 本发明提供了与相互作用或与之结合人神经生长因子（NGF）和从而中NGF的功能的抗体。 本发明还提供所述抗体和方法的药物组合物中和NGF的功能，特别是用于通过施用药学有效量的抗NGF抗体的NGF治疗相关病症（例如慢性疼痛）。 还提供了使用抗NGF抗体检测样品中的NGF的量的方法。
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