公开(公告)号：EP1551811A1

公开(公告)日：2005-07-13

申请号：EP03809075.9

申请日：2003-10-16

申请人： Amgen Inc.

发明人： BALAN, Chenera ,  BO, Yunxin ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher, H. ,  GORE, Vijay, K. ,  MA, Vu Van ,  NORMAN, Mark, H. ,  OGNYANOV, Vassil, I. ,  QIAN, Yi-xin ,  WANG, Xianghong ,  XI, Ning ,  XU, Shimin

IPC分类号： C07D235/30 ,  C07D401/12 ,  C07D401/14 ,  C07D401/04 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  C07D417/12 ,  C07D403/14 ,  C07D409/14 ,  C07D405/14 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496

CPC分类号： C07D401/04 ,  C07D235/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Compounds of formula (I) are useful in the treatment of vanilloid-receptor-meditated diseases, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis.

公开(公告)号：EP1720868B1

公开(公告)日：2009-11-04

申请号：EP05722962.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： WANG, Hui-Ling ,  BALAN, Chenera ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, Richard ,  GORE, Vijay, Keshav ,  KATON, Jodie ,  NORMAN, Mark, H.

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.

公开(公告)号：EP1745034A1

公开(公告)日：2007-01-24

申请号：EP05722957.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： BALAN, Chenera ,  CHEN, Ning ,  DOHERTY, Elizabeth M. ,  GORE, Vijay Keshav ,  NORMAN, Mark H. ,  WANG, Hui-Ling

IPC分类号： C07D401/12 ,  C07D417/12 ,  C07D413/12 ,  C07D403/12 ,  C07D417/14 ,  C07D401/14 ,  C07D403/14 ,  A61K31/44 ,  A61K31/444

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

摘要： Compounds having the general structure (I) and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndroms, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

公开(公告)号：EP1720868A1

公开(公告)日：2006-11-15

申请号：EP05722962.7

申请日：2005-02-11

申请人： AMGEN INC.

发明人： WANG, Hui-Ling ,  BALAN, Chenera ,  DOHERTY, Elizabeth, M. ,  FALSEY, James, Richard ,  GORE, Vijay, Keshav ,  KATON, Jodie ,  NORMAN, Mark, H.

IPC分类号： C07D417/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.