公开(公告)号：EP1917250B1

公开(公告)日：2010-07-21

申请号：EP06785683.1

申请日：2006-06-26

申请人： Amgen, Inc

发明人： BERGERON, Philippe ,  CHEN, Xiaoqi ,  DU, Xiaohui ,  DEIGNAN, Jeffrey ,  DUQUETTE, Jason, A. ,  GUSTIN, Darin ,  MEDINA, Julio, C. ,  MIHALIC, Jeffrey, T. ,  TONN, George, R.

IPC分类号： C07D233/54

CPC分类号： C07D233/64 ,  C07D235/14 ,  C07D239/26 ,  C07D239/90 ,  C07D401/04 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds, (I) compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease. All definitions are as given in claim 1.

公开(公告)号：EP1786782B1

公开(公告)日：2010-03-31

申请号：EP05790029.2

申请日：2005-08-11

申请人： Amgen Inc.

发明人： BERGERON, Philippe ,  FARTHING, Christopher N. ,  JONES, Stuart D. ,  LIEBESCHUETZ, John W. ,  LIVELY, Sarah E. ,  MCGEE, Lawrence R. ,  MCKENDRY, Sharon ,  SHEPPARD, David ,  YOUNG, Stephen C.

IPC分类号： C07D239/48

CPC分类号： C07D239/47 ,  C07D213/75 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/52 ,  C07D239/54 ,  C07D239/58

摘要： Compounds, compositions and methods are provided that are useful in. the treatment or preventionTof a condition or disorder mediated by PPARϜ or PPARδ. In particular, the compounds of the invention modulate the function of PPARϜ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis. The subject, compounds include bisaryl-sulfonamides that have general formula (I): wherein Ar, R1, X, Y, Z. W, L, B and R2 are described herein.

公开(公告)号：EP1786782A2

公开(公告)日：2007-05-23

申请号：EP05790029.2

申请日：2005-08-11

申请人： Amgen Inc.

发明人： BERGERON, Philippe ,  FARTHING, Christopher N. ,  JONES, Stuart D. ,  LIEBESCHUETZ, John W. ,  LIVELY, Sarah E. ,  MCGEE, Lawrence R. ,  MCKENDRY, Sharon ,  SHEPPARD, David ,  YOUNG, Stephen C.

IPC分类号： C07D239/48

CPC分类号： C07D239/47 ,  C07D213/75 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/52 ,  C07D239/54 ,  C07D239/58

摘要： Compounds, compositions and methods are provided that are useful in. the treatment or preventionTof a condition or disorder mediated by PPARϜ or PPARδ. In particular, the compounds of the invention modulate the function of PPARϜ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis. The subject, compounds include bisaryl-sulfonamides that have general formula (I): wherein Ar, R1, X, Y, Z. W, L, B and R2 are described herein.

公开(公告)号：EP1917250A2

公开(公告)日：2008-05-07

申请号：EP06785683.1

申请日：2006-06-26

申请人： Amgen, Inc

发明人： BERGERON, Philippe ,  CHEN, Xiaoqi ,  DU, Xiaohui ,  DEIGNAN, Jeffrey ,  DUQUETTE, Jason, A. ,  GUSTIN, Darin ,  MEDINA, Julio, C. ,  MIHALIC, Jeffrey, T. ,  TONN, George, R.

IPC分类号： C07D233/54

CPC分类号： C07D233/64 ,  C07D235/14 ,  C07D239/26 ,  C07D239/90 ,  C07D401/04 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds, (I) compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease. All definitions are as given in claim 1.

摘要翻译： 本文提供了可用于治疗炎症和免疫病症和疾病的化合物，（I）组合物和方法。 特别地，本发明提供了调节趋化因子受体的表达和/或功能的芳基腈化合物。 本发明方法可用于治疗炎症和免疫调节紊乱和疾病，例如多发性硬化，类风湿性关节炎，I型糖尿病，哮喘，牛皮癣和炎性肠病。 所有定义如权利要求1中给出。