公开(公告)号：EP3300500A1

公开(公告)日：2018-04-04

申请号：EP16730076.3

申请日：2016-05-18

申请人： Amgen Inc.

发明人： CHEN, Ning ,  CHEN, Xiaoqi ,  CHEN, Yinhong ,  CHENG, Alan C. ,  CONNORS, Richard V. ,  DEIGNAN, Jeffrey ,  DRANSFIELD, Paul John ,  DU, Xiaohui ,  FU, Zice ,  HEATH, Julie Anne ,  HORNE, Daniel B. ,  HOUZE, Jonathan ,  KALLER, Matthew R. ,  KHAKOO, Aarif Yusuf ,  KOPECKY, David John ,  LAI, Su-Jen ,  MA, Zhihua ,  MCGEE, Lawrence R. ,  MEDINA, Julio C. ,  MIHALIC, Jeffrey T. ,  NISHIMURA, Nobuko ,  OLSON, Steven H. ,  PATTAROPONG, Vatee ,  SWAMINATH, Gayathri ,  WANG, Xiaodong ,  YANG, Kevin ,  YEH, Wen-Chen ,  DEBENEDETTO, Mikkel V. ,  FARRELL, Robert P. ,  HEDLEY, Simon J. ,  JUDD, Ted C. ,  KAYSER, Frank

IPC分类号： C07D401/14 ,  C07D401/04 ,  C07D413/04 ,  A61K31/4196 ,  A61K31/4439 ,  A61P9/00

CPC分类号： C07D401/14 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/513 ,  A61K31/695 ,  A61K45/06 ,  C07B57/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/07 ,  C07C311/13 ,  C07D211/54 ,  C07D213/61 ,  C07D213/71 ,  C07D213/82 ,  C07D239/26 ,  C07D239/30 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D241/24 ,  C07D249/08 ,  C07D295/16 ,  C07D401/04 ,  C07D401/12 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07F7/08

摘要： where the definitions of the variables are provided herein.

公开(公告)号：EP2688887B1

公开(公告)日：2015-05-13

申请号：EP12711738.0

申请日：2012-03-21

申请人： Amgen Inc.

发明人： CHEN, Xiaoqi ,  DAI, Kang ,  DUQUETTE, Jason ,  GRIBBLE, Michael W., Jr. ,  HUARD, Justin N. ,  KEEGAN, Kathleen S. ,  LI, Zhihong ,  LIVELY, Sarah E. ,  MCGEE, Lawrence R. ,  RAGAINS, Mark L. ,  WANG, Xianghong ,  WEIDNER, Margaret F. ,  ZHANG, Jian

IPC分类号： C07D471/14 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07D519/00 ,  C07D471/14

公开(公告)号：EP2688887A1

公开(公告)日：2014-01-29

申请号：EP12711738.0

申请日：2012-03-21

申请人： Amgen Inc.

发明人： CHEN, Xiaoqi ,  DAI, Kang ,  DUQUETTE, Jason ,  GRIBBLE, Michael W., Jr. ,  HUARD, Justin N. ,  KEEGAN, Kathleen S. ,  LI, Zhihong ,  LIVELY, Sarah E. ,  MCGEE, Lawrence R. ,  RAGAINS, Mark L. ,  WANG, Xianghong ,  WEIDNER, Margaret F. ,  ZHANG, Jian

IPC分类号： C07D471/14 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07D519/00 ,  C07D471/14

摘要： Compounds of Formula I are useful inhibitors of CDK 4, CDK6, and FLT3. Such compounds are useful in treating cancer and various other disease conditions. Compounds of Formula I have the following structure: where R1 is a group of Formula IA, Formula IB, Formula IC, or Formula ID and the definitions of the other variables are provided herein.

公开(公告)号：EP1786782B1

公开(公告)日：2010-03-31

申请号：EP05790029.2

申请日：2005-08-11

申请人： Amgen Inc.

发明人： BERGERON, Philippe ,  FARTHING, Christopher N. ,  JONES, Stuart D. ,  LIEBESCHUETZ, John W. ,  LIVELY, Sarah E. ,  MCGEE, Lawrence R. ,  MCKENDRY, Sharon ,  SHEPPARD, David ,  YOUNG, Stephen C.

IPC分类号： C07D239/48

CPC分类号： C07D239/47 ,  C07D213/75 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/52 ,  C07D239/54 ,  C07D239/58

摘要： Compounds, compositions and methods are provided that are useful in. the treatment or preventionTof a condition or disorder mediated by PPARϜ or PPARδ. In particular, the compounds of the invention modulate the function of PPARϜ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis. The subject, compounds include bisaryl-sulfonamides that have general formula (I): wherein Ar, R1, X, Y, Z. W, L, B and R2 are described herein.

公开(公告)号：EP1786782A2

公开(公告)日：2007-05-23

申请号：EP05790029.2

申请日：2005-08-11

申请人： Amgen Inc.

发明人： BERGERON, Philippe ,  FARTHING, Christopher N. ,  JONES, Stuart D. ,  LIEBESCHUETZ, John W. ,  LIVELY, Sarah E. ,  MCGEE, Lawrence R. ,  MCKENDRY, Sharon ,  SHEPPARD, David ,  YOUNG, Stephen C.

IPC分类号： C07D239/48

CPC分类号： C07D239/47 ,  C07D213/75 ,  C07D237/22 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D239/52 ,  C07D239/54 ,  C07D239/58

摘要： Compounds, compositions and methods are provided that are useful in. the treatment or preventionTof a condition or disorder mediated by PPARϜ or PPARδ. In particular, the compounds of the invention modulate the function of PPARϜ or PPARδ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis. The subject, compounds include bisaryl-sulfonamides that have general formula (I): wherein Ar, R1, X, Y, Z. W, L, B and R2 are described herein.