专利检索 ap:("Amgen Inc.") AND inv:"MINATTI, Ana Elena" 第 1 页

1.

发明公开
KRAS G12C INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开

公开(公告)号：EP3790886A1

公开(公告)日：2021-03-17

申请号：EP19725595.3

申请日：2019-05-09

申请人： Amgen Inc.

发明人： MINATTI, Ana Elena , LOW, Jonathan D. , WURZ, Ryan Paul , LANMAN, Brian Alan , CEE, Victor J. , BARTBERGER, Michael D. , CHU-MOYER, Margaret

IPC分类号： C07D513/04 , A61P35/00 , A61K31/549

2.

发明公开
MACROCYCLIC COMPOUNDS THAT INHIBIT MCL-1 PROTEIN 审中-公开

公开(公告)号：EP3676270A1

公开(公告)日：2020-07-08

申请号：EP18766453.7

申请日：2018-08-27

申请人： Amgen Inc.

发明人： BROWN, Sean P. , HARRINGTON, Paul E. , LANMAN, Brian Alan , LI, Kexue , LI, Yunxiao , LOW, Jonathan D. , MA, Vu Van , MINATTI, Ana Elena

IPC分类号： C07D513/08 , A61K31/554 , A61P35/00

3.

发明公开
KIF18A INHIBITORS 审中-公开

公开(公告)号：EP3897852A1

公开(公告)日：2021-10-27

申请号：EP19842520.9

申请日：2019-12-20

申请人： Amgen Inc.

发明人： TAMAYO, Nuria A. , BANERJEE, Abhisek , BROWN, James Alexander , FROHN, Michael J. , CHEN, Jian Jeffrey , LI, Kexue , LIU, Qingyian , LOW, Jonathan Dante , MA, Vu , PETTUS, Liping H. , WALTON, Mary Catherine , MINATTI, Ana Elena , BOURBEAU, Matthew Paul , JIA, Lei

IPC分类号： A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/506 , C07D419/14 , C07D491/044

4.

发明公开
CYCLOPROPYL FUSED THIAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE 审中-公开
标题翻译：环丙烷基二苯并噻吩-2-氨基 - 维生素A酯酶法测定了维生素VERWENDUNG

公开(公告)号：EP3177618A1

公开(公告)日：2017-06-14

申请号：EP15766951.6

申请日：2015-08-05

申请人： Amgen Inc.

发明人： ALLEN, Jennifer R. , AMEGADZIE, Albert , BOURBEAU, Matthew P. , BROWN, James A. , CHEN, Jian J. , CHENG, Yuan , FROHN, Michael J. , GUZMAN-PEREZ, Angel , HARRINGTON, Paul E. , LIU, Longbin , LIU, Qingyian , LOW, Jonathan D. , MA, Vu Van , MANNING, James R. , MINATTI, Ana Elena , NGUYEN, Thomas T. , NISHIMURA, Nobuko , NORMAN, Mark H. , PETTUS, Liping H. , PICKRELL, Alexander J. , QIAN, Wenyuan , RUMFELT, Shannon , RZASA, Robert M. , SIEGMUND, Aaron C. , STEC, Markian M. , WHITE, Ryan D. , XUE, Qiufen

IPC分类号： C07D417/04 , C07D417/14 , C07D471/04 , A61K31/5415 , A61P25/28 , C07D279/08

CPC分类号： C07D417/12 , C07D279/08 , C07D417/04 , C07D417/14 , C07D471/04 , C07D513/10

摘要： wherein variables A4, A5, A6, A8, and each of Ra, Rb, R1, R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and methods for preparing compounds of the invention.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。这些化合物具有通式I：其中式I中的变量A4，A5，A6，A8以及R 1，R b，R 1，R 2，R 3和R 7各自独立地定义。本发明还提供包含该化合物的药物组合物，以及由BACE的生物活性产生的化合物和组合物用于治疗与A-β斑块形成和沉积相关的病症和/或病症的用途。这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。本发明还提供式II和III的化合物及其分子式实施方案，用于制备本发明化合物的中间体和方法。

5.

发明公开
AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE 有权
标题翻译：氨基 - 二氢恶嗪及氨基酸以β-分泌酶调节剂dihydrothiazine螺化合物及其医药用途

公开(公告)号：EP2547686A1

公开(公告)日：2013-01-23

申请号：EP11714873.4

申请日：2011-03-14

申请人： Amgen Inc.

发明人： CHEN, Jian, J. , ZHONG, Wenge , YANG, Bryant , QIAN, Wenyuan , LOPEZ, Patricia , WHITE, Ryan , WEISS, Matthew , JUDD, Ted , POWERS, Timothy , CHENG, Yuan , DINEEN, Thomas , EPSTEIN, Oleg , LOW, Jonathan , MARX, Isaac , MINATTI, Ana Elena , PARAS, Nick, A. , POTASHMAN, Michele

IPC分类号： C07D498/10 , C07D498/20 , C07D513/10 , C07D513/20 , A61K31/537 , A61K31/5386 , A61K31/547 , A61P25/28

CPC分类号： C07D513/10 , C07D498/10 , C07D498/20 , C07D513/20

摘要： The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula (I): wherein A
1 , A
2 , A
3 , A
4 , A
5 , A
6 , R
2 , R
7 , X, Y and Z of Formula (I) are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula (I), intermediates and processes useful for the preparation of compounds of Formula (I).

6.

发明公开
INHIBITORS OF KRAS G12C AND METHODS OF USING THE SAME 审中-实审

公开(公告)号：EP4403175A2

公开(公告)日：2024-07-24

申请号：EP24151885.1

申请日：2018-09-07

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan , BOOKER, Shon , GOODMAN, Clifford , REED, Anthony B. , LOW, Jonathan D. , WANG, Hui-Ling , CHEN, Ning , MINATTI, Ana Elena , WURZ, Ryan , CEE, Victor J.

IPC分类号： A61K31/519

CPC分类号： A61P35/00 , A61K31/519 , A61K31/7068 , A61K38/07 , C07D471/04

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

7.

发明公开
INHIBITORS OF KRAS G12C AND METHODS OF USING THE SAME 审中-公开

公开(公告)号：EP4141005A1

公开(公告)日：2023-03-01

申请号：EP22176014.3

申请日：2018-09-07

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan , BOOKER, Shon , GOODMAN, Clifford , REED, Anthony B. , LOW, Jonathan D. , WANG, Hui-Ling , CHEN, Ning , MINATTI, Ana Elena , WURZ, Ryan , CEE, Victor J.

IPC分类号： C07D471/04 , A61P35/00 , A61K31/519

摘要： Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.