公开(公告)号：EP2609081A1

公开(公告)日：2013-07-03

申请号：EP11752398.5

申请日：2011-08-22

申请人： Amgen Inc.

发明人： ASHTON, Kate ,  BARTBERGER, Michael David ,  BO, Yunxin ,  BRYAN, Marian C. ,  CROGHAN, Michael ,  FOTSCH, Christopher Harold ,  HALE, Clarence Henderson ,  KUNZ, Roxanne Kay ,  LIU, Longbin ,  NISHIMURA, Nobuko ,  NORMAN, Mark H. ,  PENNINGTON, Lewis Dale ,  POON, Steve Fong ,  STEC, Markian Myroslaw ,  ST. JEAN, David, Joseph, Jr. ,  TAMAYO, Nuria A. ,  TEGLEY, Christopher Michael ,  YANG, Kevin Chao

IPC分类号： C07D213/30 ,  C07D213/71 ,  C07D213/74 ,  C07D231/18 ,  C07D239/42 ,  C07D241/04 ,  C07D277/36 ,  C07D333/34 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D491/08 ,  C07D498/08

CPC分类号： C07D333/34 ,  C07C317/22 ,  C07D213/30 ,  C07D213/32 ,  C07D213/71 ,  C07D213/72 ,  C07D213/74 ,  C07D231/18 ,  C07D239/42 ,  C07D241/04 ,  C07D277/36 ,  C07D285/135 ,  C07D295/26 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D491/08 ,  C07D498/08

摘要： The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.

公开(公告)号：EP1971604B1

公开(公告)日：2012-08-01

申请号：EP06826602.2

申请日：2006-10-23

申请人： Amgen Inc.

发明人： GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP1562933B1

公开(公告)日：2008-03-19

申请号：EP03764755.9

申请日：2003-07-15

申请人： AMGEN INC.

发明人： PATEL, Vinod, F. ,  ASKEW JR, Benny, C. ,  BOOKER, Shon ,  CHEN, Guoqing ,  DIPIETRO, Lucian, V. ,  GERMAIN, Julie ,  HABGOOD, Gregory, J. ,  HUANG, Qi ,  KIM, Tae-Seong ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ELBAUM, Daniel

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D407/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4433 ,  C07D413/14

CPC分类号： C07D471/04 ,  A61K31/00 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14

摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP3630761A1

公开(公告)日：2020-04-08

申请号：EP18731624.5

申请日：2018-05-21

申请人： Amgen Inc.

发明人： LANMAN, Brian Alan ,  CHEN, Jian ,  REED, Anthony B. ,  CEE, Victor J. ,  LIU, Longbin ,  KOPECKY, David John ,  LOPEZ, Patricia ,  WURZ, Ryan Paul ,  NGUYEN, Thomas T. ,  BOOKER, Shon ,  NISHIMURA, Nobuko ,  SHIN, Youngsook ,  TAMAYO, Nuria A. ,  ALLEN, John Gordon ,  ALLEN, Jennifer Rebecca

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61P35/00 ,  C07D475/00

公开(公告)号：EP3452466A1

公开(公告)日：2019-03-13

申请号：EP17733197.2

申请日：2017-05-02

申请人： Amgen Inc.

发明人： CHEN, Xiaoqi ,  CHEN, Yinhong ,  CHENG, Alan C. ,  CONNORS, Richard V. ,  DEBENEDETTO, Mikkel V. ,  DRANSFIELD, Paul John ,  FU, Zice ,  HARVEY, James S. ,  HEATH, Julie Anne ,  HEDLEY, Simon J. ,  HOUZE, Jonathan ,  JUDD, Ted C. ,  KHAKOO, Aarif Yusuf ,  KOPECKY, David J. ,  LAI, Su-Jen ,  MA, Zhihua ,  NISHIMURA, Nobuko ,  OLSON, Steven H. ,  PATTAROPONG, Vatee ,  SWAMINATH, Gayathri ,  WANG, Xiaodong ,  YEH, Wen-Chen

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D403/14 ,  C07D405/04 ,  C07D409/14 ,  C07D471/04 ,  A61K31/4196 ,  A61P9/00

公开(公告)号：EP2424859B1

公开(公告)日：2015-04-08

申请号：EP10718364.2

申请日：2010-04-27

申请人： Amgen, Inc

发明人： ANDREWS, Kristin ,  BO, Yunxin, Y. ,  BOOKER, Shon ,  CEE, Victor, J. ,  D'ANGELO, Noel ,  HERBERICH, Bradley, J. ,  HONG, Fang-Tsao ,  JACKSON, Claire, L., M. ,  LANMAN, Brian, A. ,  LIAO, Hongyu ,  LIU, Longbin ,  NISHIMURA, Nobuko ,  NORMAN, Mark, H. ,  PETTUS, Liping, H. ,  REED, Anthony, B. ,  SMITH, Adrian, L. ,  TADESSE, Seifu ,  TAMAYO, Nuria, A. ,  WU, Bin ,  WURZ, Ryan ,  YANG, Kevin

IPC分类号： C07D401/14 ,  C07D473/00 ,  A61K31/52 ,  A61P35/00

CPC分类号： C07D473/00 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

公开(公告)号：EP2723718A1

公开(公告)日：2014-04-30

申请号：EP12730135.6

申请日：2012-06-21

申请人： Amgen Inc.

发明人： BROWN, James ,  CHEN, Jian J. ,  GORE, Vijay Keshav ,  HARRIED, Scott ,  HORNE, Daniel B. ,  KALLER, Matthew R. ,  LIU, Qingyian ,  MONENSCHEIN, Holger ,  NGUYEN, Thomas T. ,  NISHIMURA, Nobuko ,  ZHONG, Wenge

IPC分类号： C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  A61K31/44 ,  A61P25/00

CPC分类号： C07D213/53 ,  C07C275/30 ,  C07D213/40 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： Compounds of Formula (I) are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula (I) have the above structure, where the definitions of the variables are provided herein.

公开(公告)号：EP2307400B1

公开(公告)日：2014-04-23

申请号：EP09767432.9

申请日：2009-05-29

申请人： Amgen, Inc

发明人： BO, Yunxin Y. ,  BOOKER, Shon ,  BRYAN, Marian ,  DEAK, Holly L. ,  LIU, Longbin ,  ANDREWS, Kristin ,  NISHIMURA, Nobuko ,  NORMAN, Mark H. ,  PANTER, Kathleen ,  SCHENKEL, Laurie ,  SIEGMUND, Aaron C. ,  TAMAYO, Nuria A. ,  YANG, Kevin

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  A61K31/498 ,  A61K31/502 ,  A61K31/4709 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D471/04

公开(公告)号：EP1656355A2

公开(公告)日：2006-05-17

申请号：EP04820712.0

申请日：2004-06-21

申请人： AMGEN INC.

发明人： CHEN, Jian, J. ,  ASKEW, Ben, C. ,  BISWAS, Kaustav ,  CHAU, Jennifer, N. ,  D'AMICIO, Derin, C. ,  HARRIED, Scott ,  NGUYEN, Thomas ,  QIAN, Wenyuan ,  ZHU, Jiawang ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  LI, Aiwen ,  LIU, Qingyian ,  NISHIMURA, Nobuko ,  NOMAK, Rana ,  PETERKIN, Tanya ,  RIAHI, Babak ,  YANG, Kevin ,  YUAN, Chester, Chenguang

IPC分类号： C07D241/00

CPC分类号： C07D241/08 ,  C07D243/08 ,  C07D245/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14

摘要： Compounds (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation, and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

公开(公告)号：EP4007638A1

公开(公告)日：2022-06-08

申请号：EP20768136.2

申请日：2020-08-03

申请人： Amgen Inc.

发明人： TAMAYO, Nuria A. ,  ALLEN, John Gordon ,  BANERJEE, Abhisek ,  CHEN, Jian Jeffrey ,  FROHN, Michael J. ,  KALLER, Matthew Richard ,  NGUYEN, Thomas T. ,  NISHIMURA, Nobuko ,  XUE, Qiufen May

IPC分类号： A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D498/08 ,  A61K31/444