公开(公告)号：EP2315751A1

公开(公告)日：2011-05-04

申请号：EP09770549.5

申请日：2009-06-26

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  CUSHING, Timothy, D. ,  FISHER, Benjamin ,  HE, Xiao ,  LI, Kexue ,  LI, Zhihong ,  MCGEE, Lawrence, R. ,  PATTAROPONG, Vatee ,  FAULDER, Paul ,  SEGANISH, Jennifer, L. ,  SHIN, Youngsook ,  WANG, Zhulun ,  LIU, Wen

IPC分类号： C07D213/82 ,  C07D233/88 ,  C07D407/08 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10 ,  A61K31/506 ,  A61K31/404

CPC分类号： C07D413/14 ,  C07D213/82 ,  C07D233/88 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/08 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10

摘要： Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.