公开(公告)号：EP3788037A1

公开(公告)日：2021-03-10

申请号：EP19723581.5

申请日：2019-04-30

申请人： Amgen Inc.

发明人： PATTAROPONG, Vatee ,  RAMSDEN, Philip Dean

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D401/12 ,  C07D403/14 ,  A61P3/00 ,  A61P9/00 ,  A61P13/12 ,  C07D239/545

公开(公告)号：EP3452466A1

公开(公告)日：2019-03-13

申请号：EP17733197.2

申请日：2017-05-02

申请人： Amgen Inc.

发明人： CHEN, Xiaoqi ,  CHEN, Yinhong ,  CHENG, Alan C. ,  CONNORS, Richard V. ,  DEBENEDETTO, Mikkel V. ,  DRANSFIELD, Paul John ,  FU, Zice ,  HARVEY, James S. ,  HEATH, Julie Anne ,  HEDLEY, Simon J. ,  HOUZE, Jonathan ,  JUDD, Ted C. ,  KHAKOO, Aarif Yusuf ,  KOPECKY, David J. ,  LAI, Su-Jen ,  MA, Zhihua ,  NISHIMURA, Nobuko ,  OLSON, Steven H. ,  PATTAROPONG, Vatee ,  SWAMINATH, Gayathri ,  WANG, Xiaodong ,  YEH, Wen-Chen

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D403/14 ,  C07D405/04 ,  C07D409/14 ,  C07D471/04 ,  A61K31/4196 ,  A61P9/00

公开(公告)号：EP2061760A1

公开(公告)日：2009-05-27

申请号：EP07811731.4

申请日：2007-09-06

申请人： Amgen, Inc

发明人： BROWN, Sean P. ,  DRANSFIELD, Paul ,  HOUZE, Jonathan B. ,  LIU, Jinqian ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  PATTAROPONG, Vatee ,  SCHMITT, Michael J. ,  SHARMA, Rajiv ,  WANG, Yingcai

IPC分类号： C07D213/55 ,  C07D231/12 ,  C07D233/64 ,  C07D239/26 ,  C07D249/10 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D285/12 ,  C07D333/24 ,  C07D207/327 ,  C07D277/587 ,  C07C59/72 ,  C07C233/65 ,  A61K31/192 ,  A61K31/40

CPC分类号： C07D233/64 ,  C07C51/09 ,  C07C51/367 ,  C07C51/47 ,  C07C235/34 ,  C07C2602/10 ,  C07D207/327 ,  C07D213/55 ,  C07D231/12 ,  C07D239/26 ,  C07D249/10 ,  C07D257/04 ,  C07D261/08 ,  C07D263/32 ,  C07D277/587 ,  C07D285/12 ,  C07D333/24 ,  C07C59/72

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L1, ℗, L2, M, X, L3, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量Q，L1，L2，M，X，L3和A的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病如II型糖尿病中的使用方法。

公开(公告)号：EP2358656B1

公开(公告)日：2014-01-01

申请号：EP09741123.5

申请日：2009-10-13

申请人： Amgen, Inc

发明人： BROWN, Sean P. ,  DRANSFIELD, Paul ,  DU, Xiaohui ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, XianYun ,  LAI, SuJen ,  LI, An-Rong ,  LIU, Jiwen ,  MA, Zhihua ,  MEDINA, Julio C. ,  PATTAROPONG, Vatee ,  SHEN, Wang ,  VIMOLRATANA, Marc ,  WANG, Yingcai ,  WANG, Zhongyu ,  YU, Ming ,  ZHU, Liusheng

IPC分类号： C07C62/34 ,  C07D249/00 ,  C07D277/00 ,  C07D311/00 ,  C07D231/00 ,  C07D271/00 ,  C07D221/00

CPC分类号： C07C62/34 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07D213/643 ,  C07D217/24 ,  C07D253/065 ,  C07D277/22 ,  C07D311/04 ,  C07D401/12

公开(公告)号：EP2139843B1

公开(公告)日：2013-12-25

申请号：EP08742774.6

申请日：2008-04-10

申请人： Amgen, Inc

发明人： BROWN, Sean, P. ,  DRANSFIELD, Paul ,  FU, Zice ,  HOUZE, Jonathan ,  JIAO, Xian, Yun ,  KOHN, Todd, J. ,  PATTAROPONG, Vatee ,  VIMOLRATANA, Marc ,  SCHMITT, Michael, J.

IPC分类号： C07C59/68 ,  C07C59/72 ,  C07D261/08 ,  A61K31/41 ,  A61K31/19 ,  A61P3/00

CPC分类号： C07C59/68 ,  C07C59/72 ,  C07D261/08

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

公开(公告)号：EP2588471A1

公开(公告)日：2013-05-08

申请号：EP11734209.7

申请日：2011-06-30

申请人： Amgen Inc.

发明人： DRANSFIELD, Paul, John ,  GONZALEZ LOPEZ DE TURISO, Felix ,  KOHN, Todd, J. ,  PATTAROPONG, Vatee ,  SIMARD, Jillian, L.

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/107 ,  A61K31/4709 ,  A61K31/4375 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/4375 ,  A61K31/4709 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D491/107

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

公开(公告)号：EP2205548A1

公开(公告)日：2010-07-14

申请号：EP08837085.3

申请日：2008-10-03

申请人： Amgen, Inc

发明人： KIM, Yong-Jae ,  BROWN, Sean, P. ,  CAO, Qiong ,  DRANSFIELD, Paul, J. ,  DU, Xiaohui ,  HOUZE, Jonathan ,  JIAO, Xian Yun ,  KOHN, Todd, J. ,  LAI, Sujen ,  LI, An-Rong ,  LIN, Daniel ,  LUO, Jian ,  MEDINA, Julio, C. ,  REAGAN, Jeffrey, D. ,  PATTAROPONG, Vatee ,  SCHWARZ, Margrit ,  SHEN, Wang ,  SU, Yongli ,  SWAMINATH, Gayathri ,  VIMOLRATANA, Marc ,  WANG, Xiang ,  XIONG, Yumei ,  YANG, Li ,  YU, Ming ,  ZHANG, Jie ,  ZHU, Liusheng ,  FU, Zice ,  LIU, Jiwen ,  WANG, Yingcai

IPC分类号： C07C59/68 ,  C07C217/54 ,  C07C323/19 ,  C07D213/64 ,  A61K31/192 ,  A61K31/4415 ,  A61P3/10

CPC分类号： C07C323/62 ,  C07C59/68 ,  C07C59/72 ,  C07C217/54 ,  C07C217/62 ,  C07C317/22 ,  C07C323/19 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D213/64 ,  C07D309/12

摘要： The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

摘要翻译： 本发明提供了可用于例如治疗受试者代谢紊乱的化合物。 这些化合物具有通式I：其中本文提供变量的定义。 本发明还提供了组合物，其包括化合物在制备药物和用于治疗代谢性疾病如II型糖尿病中的使用方法。

公开(公告)号：EP2445886B1

公开(公告)日：2016-03-30

申请号：EP10729753.3

申请日：2010-06-25

申请人： Amgen, Inc

发明人： CUSHING, Timothy D. ,  DRANSFIELD, Paul John ,  GONZALEZ LOPEZ DE TURISO, Felix ,  JOHNSON, Michael G. ,  KOHN, Todd J. ,  PATTAROPONG, Vatee ,  SIMARD, Jillian L.

IPC分类号： C07D215/44 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4706 ,  A61K31/4709 ,  A61P29/00

CPC分类号： C07D401/04 ,  C07D215/44 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP2445902A2

公开(公告)日：2012-05-02

申请号：EP10728552.0

申请日：2010-06-25

申请人： Amgen, Inc

发明人： BROWN, Matthew ,  CHEN, Yi ,  CUSHING, Timothy D. ,  GONZALEZ LOPEZ DE TURISO, Felix ,  HE, Xiao ,  KOHN, Todd J. ,  LOHMAN, Julia Winslow ,  PATTAROPONG, Vatee ,  SEGANISH, Jennifer ,  SHIN, Youngsook ,  SIMARD, Jillian L.

IPC分类号： C07D401/14

CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D491/107 ,  C07D491/113 ,  C07D491/20 ,  C07D495/10 ,  C07D513/04

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

公开(公告)号：EP2315751A1

公开(公告)日：2011-05-04

申请号：EP09770549.5

申请日：2009-06-26

申请人： Amgen Inc.

发明人： CHEN, Guoqing ,  CUSHING, Timothy, D. ,  FISHER, Benjamin ,  HE, Xiao ,  LI, Kexue ,  LI, Zhihong ,  MCGEE, Lawrence, R. ,  PATTAROPONG, Vatee ,  FAULDER, Paul ,  SEGANISH, Jennifer, L. ,  SHIN, Youngsook ,  WANG, Zhulun ,  LIU, Wen

IPC分类号： C07D213/82 ,  C07D233/88 ,  C07D407/08 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10 ,  A61K31/506 ,  A61K31/404

CPC分类号： C07D413/14 ,  C07D213/82 ,  C07D233/88 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/08 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/06 ,  C07D487/10 ,  C07D487/16 ,  C07D491/10 ,  C07D495/10

摘要： Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.