公开(公告)号：EP2311829A1

公开(公告)日：2011-04-20

申请号：EP10176821.6

申请日：2002-01-11

申请人： Amgen Inc.

发明人： Chen, Guoqung ,  Adams, Jeffrey ,  Bemis, Jean ,  Booker, Shon ,  Cai, Guolin ,  Croghan, Michael ,  Dipietro, Lucian ,  Dominguez, Celia ,  Elbaum, Daniel ,  Germain, Julie ,  Geuns-Meyer, Stephanie ,  Handley, Michael ,  Huang, Qi ,  Kim, L. Joseph ,  Kim, Tae-Seong ,  Kiselyov, Alexander ,  Ouyang, Xiaohu ,  Patel, Vinod, F. ,  Smith, Leon, M. ,  Markian, Stec ,  Tasker, Andrew ,  Xi, Ning ,  Xu, Shimin ,  Yuan, Chester, Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 选定的杂环化合物对于预防和治疗疾病如血管生成介导的疾病是有效的。 本发明包括新型化合物，类似物，前药和药学上可接受的衍生物，用于预防和治疗涉及癌症等的疾病和其他疾病或病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。

公开(公告)号：EP1798230A1

公开(公告)日：2007-06-20

申请号：EP07003413.7

申请日：2002-01-11

申请人： Amgen Inc.

发明人： Chen, Guoqing ,  Adams, Jeffrey ,  Bemis, Jean ,  Booker, Shon ,  Cai, Guolin ,  Croghan, Michael ,  Dipietro, Lucian ,  Dominguez, Celia ,  Elbaum, Daniel ,  Germain, Julie ,  Geuns-Meyer, Stephanie ,  Handley, Michael ,  Huang, Qi ,  Kim, L. Joseph ,  Kim, Tae-Seong ,  Kiselyov, Alexander ,  Ouyang, Xiaohu ,  Patel, Vinod, F. ,  Smith, Leon, M. ,  Stec, Markian ,  Tasker, Andrew ,  Xi, Ning ,  Xu, Shimin ,  Yuan, Chester, Chenguang

IPC分类号： C07D409/12 ,  C07D409/14 ,  C07D213/82 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D413/14 ,  C07D417/14 ,  C07D405/14 ,  C07D405/12

CPC分类号： C07D213/82 ,  A61K31/443 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/538 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/00 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.