-
公开(公告)号：EP4240768A2
公开(公告)日：2023-09-13
申请号：EP21815915.0
申请日：2021-11-08
发明人： EVERTS, Stephanie , KLINGER, Matthias , NAEGELE, Virginie , ZALEWSKI, Adam , BLUEMEL, Claudia , BOEHM, Thomas , BROZY, Johannes , D'ANGELO, Igor , KUFER, Peter , LUTTERBUESE, Petra , MUENZ, Markus , RAU, Doris , RAUM, Tobias , RATTEL, Benno , THOMAS, Oliver , ULLRICH, Ines , WAHL, Joachim , WEBHOFER, Christian , WEIDLER, Sascha , PHAM, Elizabeth , BAILIS, Julie
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395
-
公开(公告)号：EP4055050A2
公开(公告)日：2022-09-14
申请号：EP20816095.2
申请日：2020-11-06
发明人： ANLAHR, Jonas , ARVEDSON, Tara , BAILIS, Julie , CHUN, Matthew , D'ANGELO, Igor , DAHLHOFF, Christoph , EVERTS, Stephanie , FRIEDRICH, Matthias , GAEDTKE, Lars , HOFFMANN, Patrick , GOLDSTEIN, Rebecca , HONER, Jonas Karl-Josef , KISCHEL, Roman , KLINGER, Matthias , KUFER, Peter , MUENZ, Markus , NAEGELE, Virginie , PANZER, Marc , RAU, Doris , RAUM, Tobias , ULLRICH, Ines
-
公开(公告)号：EP4240767A1
公开(公告)日：2023-09-13
申请号：EP21815914.3
申请日：2021-11-08
-
公开(公告)号：EP2552964B1
公开(公告)日：2019-10-02
申请号：EP11711591.5
申请日：2011-04-01
发明人： KUFER, Peter , KISCHEL, Roman , RAU, Doris , HOFFMANN, Patrick , LUTTERBUESE, Ralf , KLINGER, Matthias , STEIGER, Carola , FLUHR, Petra , HAUSMANN, Susanne , MANGOLD, Susanne , SCHALLER, Evelyne , RAUM, Tobias
IPC分类号： C07K16/28 , C07K16/30 , C07K16/40 , A61K39/395
-
5.发明授权CROSS-SPECIES-SPECIFIC CD3-EPSILON BINDING DOMAIN 有权KREUZSPEZIESSPEZIFISCHE CD3-EPSILON-BINDUNGSDOMÄNE
公开(公告)号：EP2155783B1
公开(公告)日：2013-07-31
申请号：EP08735001.3
申请日：2008-04-03
发明人： KLINGER, Matthias , RAUM, Tobias , RAU, Doris , MANGOLD, Susanne , KISCHEL, Roman , LUTTERBÜSE, Ralf , HOFFMANN, Patrick , KUFER, Peter
IPC分类号： C07K16/28 , C07K16/46 , C07K14/705 , C07K16/30 , C07K16/32 , C07K16/08 , C07K16/10 , C07K16/42 , A61K39/395 , A61P35/00 , A61P35/02 , A61P31/12 , A61P31/14
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/082 , C07K16/109 , C07K16/2803 , C07K16/2863 , C07K16/2878 , C07K16/2884 , C07K16/30 , C07K16/3053 , C07K16/3092 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/40 , G01N33/566 , G01N33/57492 , G01N2500/00
-
6.发明公开
公开(公告)号：EP3760210A1
公开(公告)日：2021-01-06
申请号：EP20182831.6
申请日：2014-02-07
发明人： KLINGER, Matthias , HOFFMANN, Patrick , NAEGELE, Virginie , DOPFER, Elaine-Pashupati , NAGORSEN, Dirk , SCHEELE, Juergen , ZUGMAIER, Gerhard , KUFER, Peter
IPC分类号： A61K31/737
摘要： The present invention relates in essence to a compound which decreases or inhibits the binding of mammalian T-cells to mammalian endothelial cells for use in a method of prophylaxis and/or amelioration and/or treatment of clinical adverse events caused by therapy which comprises re-directing of T-cells against target cells in a patient. Methods of treatment of patients having or being at risk of clinical adverse events caused by therapy which comprises re-directing of T-cells against target cells are also contemplated.
-
公开(公告)号：EP3298042A1
公开(公告)日：2018-03-28
申请号：EP16728620.2
申请日：2016-05-19
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2809 , C07K16/3061 , C07K2317/31 , C07K2317/622 , C07K2317/73
摘要： The present invention in general relates to the field of medical treatments and diagnostic markers, and more specifically to methods and uses for treatment of acute lymphocytic leukemia (ALL) which involve administration of a B-cell depleting agent. Uses and methods for conserving or increasing the number of long term survivors of ALL are also envisaged. The uses and methods provided herein comprise administration of a B-cell depleting agent and/or adjusting of the treatment regimen or dosage of the B-cell depleting agent so that the number of B-cells in the blood of the treated patients remains or falls below one B-cell/ml serum within a predefined period of time.
-
8.发明授权CROSS-SPECIES-SPECIFIC PSCAXCD3, CD19XCD3, C-METXCD3, ENDOSIALINXCD3, EPCAMXC D3, IGF-1RXCD3 OR FAPALPHA XCD3 BISPECIFIC SINGLE CHAIN ANTIBODY 有权特异性的PSCAXCD3，CD19XCD3，C-METXCD3，ENDOSIALINXCD3，EPCAMXC D3，IGF-1RXCD3或FAPALPHAXCD3双特异性单链抗体
公开(公告)号：EP2370467B1
公开(公告)日：2016-09-07
申请号：EP09740078.2
申请日：2009-10-01
发明人： KUFER, Peter , RAUM, Tobias , KISCHEL, Roman , LUTTERBÜSE, Ralf , HOFFMANN, Patrick , RAU, Doris , KLINGER, Matthias , MANGOLD, Susanne , BLÜMEL, Claudia
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/22 , C07K16/2803 , C07K16/2851 , C07K16/2863 , C07K16/30 , C07K16/3069 , C07K16/40 , C07K2317/31 , C07K2317/34
-
9.发明公开
公开(公告)号：EP2552964A1
公开(公告)日：2013-02-06
申请号：EP11711591.5
申请日：2011-04-01
发明人： KUFER, Peter , KISCHEL, Roman , RAU, Doris , HOFFMANN, Patrick , LUTTERBUESE, Ralf , KLINGER, Matthias , STEIGER, Carola , FLUHR, Petra , HAUSMANN, Susanne , MANGOLD, Susanne , SCHALLER, Evelyne , RAUM, Tobias
IPC分类号： C07K16/28 , C07K16/30 , C07K16/40 , A61K39/395
CPC分类号： C07K16/468 , C07K16/2809 , C07K16/30 , C07K16/3069 , C07K2317/31 , C07K2317/33 , C07K2317/622
摘要： The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
-
公开(公告)号：EP4180458A1
公开(公告)日：2023-05-17
申请号：EP22178586.8
申请日：2009-10-01
发明人： KUFER, Peter , RAUM, Tobias , KISCHEL, Roman , LUTTERBUESE, Ralf , HOFFMANN, Patrick , RAU, Doris , MANGOLD, Susanne , KLINGER, Matthias , SCHALLER, Evelyne , HAUSMANN, Susanne , FLUHR, Petra , STEIGER, Carola
摘要： The present invention relates to a bispecific single chain antibody molecule comprising a first binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 epsilon chain, wherein the epitope is part of an amino acid sequence comprised in the group consisting of SEQ ID NOs. 2, 4, 6, and 8, and a second binding domain capable of binding to prostate-specific membrane antigen (PSMA). The invention also provides nucleic acids encoding said bispecific single chain antibody molecule as well as vectors and host cells and a process for its production. The invention further relates to pharmaceutical compositions comprising said bispecific single chain antibody molecule and medical uses of said bispecific single chain antibody molecule.
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.03 秒)
