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公开(公告)号：EP4240768A2
公开(公告)日：2023-09-13
申请号：EP21815915.0
申请日：2021-11-08
发明人： EVERTS, Stephanie , KLINGER, Matthias , NAEGELE, Virginie , ZALEWSKI, Adam , BLUEMEL, Claudia , BOEHM, Thomas , BROZY, Johannes , D'ANGELO, Igor , KUFER, Peter , LUTTERBUESE, Petra , MUENZ, Markus , RAU, Doris , RAUM, Tobias , RATTEL, Benno , THOMAS, Oliver , ULLRICH, Ines , WAHL, Joachim , WEBHOFER, Christian , WEIDLER, Sascha , PHAM, Elizabeth , BAILIS, Julie
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395
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2.发明公开
公开(公告)号：EP4093771A1
公开(公告)日：2022-11-30
申请号：EP21705378.4
申请日：2021-01-22
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公开(公告)号：EP4039709A1
公开(公告)日：2022-08-10
申请号：EP21214955.3
申请日：2017-02-02
发明人： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：EP3411402A1
公开(公告)日：2018-12-12
申请号：EP17703376.8
申请日：2017-02-02
发明人： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
IPC分类号： C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/94 , C07K2319/00
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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5.发明公开OPTIMIZED CROSS-SPECIES SPECIFIC BISPECIFIC SINGLE CHAIN ANTIBODY CONSTRUCTS 审中-公开优化的跨物种特异性双特异性单链抗体构建体
公开(公告)号：EP3174901A1
公开(公告)日：2017-06-07
申请号：EP15756479.0
申请日：2015-07-31
发明人： RATTEL, Benno , FRIEDRICH, Matthias , KUFER, Peter , HOFFMANN, Patrick , RAUM, Tobias , MUNZ, Markus , HERRMANN, Ines , LUTTERBUESE, Ralf , NAHRWOLD, Elisabeth
CPC分类号： C07K16/468 , A61K2039/505 , C07K14/765 , C07K16/2803 , C07K16/2809 , C07K2317/14 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/622 , C07K2317/73 , C07K2317/94 , C07K2319/31
摘要： The present invention provides to a bispecific single chain antibody construct binding to a target cell surface antigen via a first binding domain and to the T cell surface antigen CD3 via a second binding domain, wherein serum albumin is fused to the C-terminus of the antibody construct. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
摘要翻译： 本发明提供了一种双特异性单链抗体构建体，其通过第一结合结构域与靶细胞表面抗原结合并经由第二结合结构域与T细胞表面抗原CD3结合，其中血清白蛋白与抗体的C端融合 构造。 此外，本发明提供编码抗体构建体的多核苷酸，包含所述多核苷酸的载体和用所述载体转化或转染的宿主细胞。 此外，本发明提供了用于产生本发明的抗体构建体的方法，所述抗体构建体的医学用途以及包含所述抗体构建体的试剂盒。
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公开(公告)号：EP4219562A2
公开(公告)日：2023-08-02
申请号：EP23157688.5
申请日：2016-08-01
发明人： RAUM, Tobias , PENDZIALEK, Jochen , BLUEMEL, Claudia , BOTT, Franziska , DAHLHOFF, Christoph , HOFFMANN, Patrick , NAHRWOLD, Elisabeth , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：EP4219562A3
公开(公告)日：2023-09-06
申请号：EP23157688.5
申请日：2016-08-01
发明人： RAUM, Tobias , PENDZIALEK, Jochen , BLUEMEL, Claudia , BOTT, Franziska , DAHLHOFF, Christoph , HOFFMANN, Patrick , NAHRWOLD, Elisabeth , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：EP3411403A1
公开(公告)日：2018-12-12
申请号：EP17703379.2
申请日：2017-02-02
发明人： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
CPC分类号： C07K16/30 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/64 , C07K2317/94 , C07K2319/00
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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公开(公告)号：EP3912999A1
公开(公告)日：2021-11-24
申请号：EP21162845.8
申请日：2016-08-01
发明人： RAUM, Tobias , KUFER, Peter , RAU, Doris , MUENZ, Markus , HERRMANN, Ines , HOFFMANN, Patrick , BROZY, Johannes , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
摘要： The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human EGFRVIII on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
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公开(公告)号：EP3411404A1
公开(公告)日：2018-12-12
申请号：EP17703714.0
申请日：2017-02-02
发明人： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/622 , C07K2317/64
摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
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