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    ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN
    1.
    发明公开
    ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN 审中-公开
    抗SCLEROSTIN抗体及其作为治疗方案治疗骨质疏松症的用途

    公开(公告)号：EP3230315A1

    公开(公告)日：2017-10-18

    申请号：EP15816412.9

    申请日：2015-12-11

    申请人： Amgen Inc. ,  UCB Pharma S.A.

    发明人： ROBINSON, Martyn Kim ,  OMINSKY, Michael Stuart ,  LI, Xiaodong ,  KE, Hua Zhu

    IPC分类号： C07K16/22 ,  A61K39/00

    CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61P19/08 ,  A61P19/10 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/94

    摘要： The invention relates to the treatment of bone disorders. In particular, the invention provides an approach involving administration of a high initial dose or doses of an sclerostin antibody to bring about a rapid increase in bone formation, followed by administration of lowers doses of the antibody to give a sustained lower rate of bone formation after the initial burst of bone formation. The invention also provides an approach involving decreasing dosing frequency with such an antibody to control bone formation. The approaches may be used in particular in those subjects who would benefit most from such an initial rapid burst of bone formation. Examples of such subjects include subjects who have been recently diagnosed or are experiencing severe symptoms of the disorder, as well as those subjects who have been administered a different treatment for the bone disorder which is proving ineffective. The approaches may be used in combination with each other.

    摘要翻译： 本发明涉及骨疾病的治疗。 具体而言，本发明提供了一种方法，其涉及施用高初始剂量或多个剂量的硬骨素抗体以引起骨形成的快速增加，接着施用较低剂量的抗体以在骨形成后持续降低骨形成速率 最初爆发的骨骼形成。 本发明还提供了一种涉及用这种抗体控制骨形成来降低给药频率的方法。 这些方法可以特别用于那些将从这种最初的骨形成快速爆发中获益最多的受试者。 这些受试者的实例包括最近已被诊断或正在经历该病症的严重症状的受试者，以及那些已经被证明无效的已被施用不同骨治疗方法的受试者。 这些方法可以相互结合使用。