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    ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN
    1.
    发明公开
    ANTI-SCLEROSTIN ANTIBODIES AND THEIR USE TO TREAT BONE DISORDERS AS PART OF A REGIMEN 审中-公开
    抗SCLEROSTIN抗体及其作为治疗方案治疗骨质疏松症的用途

    公开(公告)号：EP3230315A1

    公开(公告)日：2017-10-18

    申请号：EP15816412.9

    申请日：2015-12-11

    申请人： Amgen Inc. ,  UCB Pharma S.A.

    发明人： ROBINSON, Martyn Kim ,  OMINSKY, Michael Stuart ,  LI, Xiaodong ,  KE, Hua Zhu

    IPC分类号： C07K16/22 ,  A61K39/00

    CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61P19/08 ,  A61P19/10 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/94

    摘要： The invention relates to the treatment of bone disorders. In particular, the invention provides an approach involving administration of a high initial dose or doses of an sclerostin antibody to bring about a rapid increase in bone formation, followed by administration of lowers doses of the antibody to give a sustained lower rate of bone formation after the initial burst of bone formation. The invention also provides an approach involving decreasing dosing frequency with such an antibody to control bone formation. The approaches may be used in particular in those subjects who would benefit most from such an initial rapid burst of bone formation. Examples of such subjects include subjects who have been recently diagnosed or are experiencing severe symptoms of the disorder, as well as those subjects who have been administered a different treatment for the bone disorder which is proving ineffective. The approaches may be used in combination with each other.

    摘要翻译： 本发明涉及骨疾病的治疗。 具体而言，本发明提供了一种方法，其涉及施用高初始剂量或多个剂量的硬骨素抗体以引起骨形成的快速增加，接着施用较低剂量的抗体以在骨形成后持续降低骨形成速率 最初爆发的骨骼形成。 本发明还提供了一种涉及用这种抗体控制骨形成来降低给药频率的方法。 这些方法可以特别用于那些将从这种最初的骨形成快速爆发中获益最多的受试者。 这些受试者的实例包括最近已被诊断或正在经历该病症的严重症状的受试者，以及那些已经被证明无效的已被施用不同骨治疗方法的受试者。 这些方法可以相互结合使用。

    TREATMENT FOR BONE DISEASES
    7.
    发明公开
    TREATMENT FOR BONE DISEASES 审中-公开

    公开(公告)号：EP3626267A1

    公开(公告)日：2020-03-25

    申请号：EP19205429.4

    申请日：2013-07-03

    申请人： UCB Pharma, S.A.

    发明人： ROBINSON, Martyn Kim

    IPC分类号： A61K39/395 ,  C07K16/22

    摘要： The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to 5 anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some 10 instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.

    TREATMENT FOR BONE DISEASES
    9.
    发明公开
    TREATMENT FOR BONE DISEASES 审中-公开
    BEHANDLUNG VON KNOCHENERKRANKUNGEN

    公开(公告)号：EP2869844A1

    公开(公告)日：2015-05-13

    申请号：EP13733322.5

    申请日：2013-07-03

    申请人： UCB Pharma S.A.

    发明人： ROBINSON, Martyn Kim

    IPC分类号： A61K39/395 ,  C07K16/22

    摘要： The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.

    摘要翻译： 本发明涉及骨病的治疗。 特别地，本发明涉及使用剂量假期来帮助克服当将多种剂量的抗体给予受试者时随时间发展的抗硬化蛋白抗体的抗性。 通过给予受治疗的这样的给药假期，受试者随后可以显示对后续剂量的抗硬化性抗体的增加的应答。 受试者可以给予一批至少两个剂量的抗硬皮素抗体和给药假期的多个周期。 在某些情况下，可以监控受试者以帮助确定何时给予假期。 此外，可以从抗硬化蛋白酶抗体给药假期期间对受试者进行不同的治疗。