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1.发明公开NOVEL COMPOUNDS FOR PREVENTING AND/OR TREATING LYSOSOMAL STORAGE DISORDERS AND/OR DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM 审中-公开新化合物的预防和/或治疗溶酶体贮积疾病和/或退化性疾病的中枢神经系统
公开(公告)号：EP2831043A1
公开(公告)日：2015-02-04
申请号：EP13710951.8
申请日：2013-03-07
IPC分类号： C07D211/44 , A61K31/445 , A61P25/00
CPC分类号： H01L27/10855 , A61K31/445 , A61K45/06 , C07D211/44 , H01L21/31111 , H01L21/32139 , H01L27/10814 , H01L27/10852 , H01L27/10873 , H01L27/10894 , H01L28/90
摘要： Described are novel salts of the compound (3R,4R,5S)-5-(difluoromethyl) piperidine-3,4-diol, as well as methods of using the same for preventing and/or treating lysosomal storage disorders and/or degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease and/or Parkinson's disease.
摘要翻译： 描述为化合物（3R，4R，5S）-5-（二氟甲基）哌啶-3,4-二醇，新颖的盐以及使用其的预防和/或治疗溶酶体贮积症和/或退化性疾病的方法 中枢神经系统的，特别是，本发明提供用于预防和/或治疗戈谢病和/或帕金森病的方法。
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2.发明公开METHOD FOR TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE THE ACTIVITY OF GANGLIOSIDASES 有权阿尔茨海默氏病药理伴侣的治疗方法来增加GANGLIOSIDASEN的活度
公开(公告)号：EP2490712A1
公开(公告)日：2012-08-29
申请号：EP10825421.0
申请日：2010-10-12
CPC分类号： A61K31/7008 , A61K31/426 , A61K31/429 , A61K31/445 , A61K38/1709 , G06F19/00
摘要： The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.
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3.发明公开METHODS FOR PREVENTING AND/OR TREATING DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM 有权方法预防和/或治疗中枢神经系统退行性疾病的
公开(公告)号：EP2416655A1
公开(公告)日：2012-02-15
申请号：EP10762468.6
申请日：2010-04-09
发明人： BOYD, Robert , LEE, Gary
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： A61K31/445
摘要： The present invention provides methods for preventing and/or treating degenerative disorders of the central nervous system using 5- (fluoromethyl)piperdine-3,4-diol, 5-(chloromethyl)piperdine-3,4-diol, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, or any combination of two or more thereof. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.
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公开(公告)号：EP3615509A1
公开(公告)日：2020-03-04
申请号：EP18724397.7
申请日：2018-04-25
发明人： BOYD, Robert
IPC分类号： C07C215/44 , A61K31/133 , A61P25/28
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5.发明公开NOVEL COMPOSITIONS FOR PREVENTING AND/OR TREATING DEGENERATIVE DISORDERS OF THE CENTRAL NERVOUS SYSTEM 审中-公开用于预防新型组合物和/或中枢神经系统退行性疾病治疗中
公开(公告)号：EP3143875A1
公开(公告)日：2017-03-22
申请号：EP16191218.3
申请日：2010-10-05
发明人： BOYD, Robert , LEE, Gary , RYBCZYNSKI, Philip
IPC分类号： A01N43/40 , A61K31/445 , C07D211/46 , C07D211/60
摘要： The present invention provides novel compounds
as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.摘要翻译： 本发明提供了新颖的化合物以及组合物和方法使用相同的用于预防和/或治疗中枢神经系统的变性疾病。特别地，本发明提供用于预防和/或治疗帕金森氏病的方法。
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6.发明公开
公开(公告)号：EP2490533A1
公开(公告)日：2012-08-29
申请号：EP10825397.2
申请日：2010-10-05
发明人： BOYD, Robert , LEE, Gary , RYBCZYNSKI, Philip
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D211/46 , A61K31/15 , A61K31/445 , A61K38/47 , C07D211/96
摘要： The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.
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公开(公告)号：EP3143875B1
公开(公告)日：2020-05-27
申请号：EP16191218.3
申请日：2010-10-05
发明人： BOYD, Robert , LEE, Gary , RYBCZYNSKI, Philip
IPC分类号： A01N43/40 , A61K31/445 , C07D211/46 , C07D211/60
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8.发明公开
公开(公告)号：EP3390408A1
公开(公告)日：2018-10-24
申请号：EP16820502.9
申请日：2016-12-14
发明人： BOYD, Robert
IPC分类号： C07D513/04 , C07D211/56 , A61K31/445 , A61P25/28
CPC分类号： C07D513/04 , C07D211/56
摘要： Described herein are novel compounds and methods for the treatment and/or prevention of cerebral amyloidoses such as Alzheimer's disease (AD) and/or cerebral amyloid angiopathy (CAA).
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公开(公告)号：EP2416656B1
公开(公告)日：2015-12-23
申请号：EP10762469.4
申请日：2010-04-09
发明人： BOYD, Robert , LEE, Gary
IPC分类号： A61K31/445 , C12Q1/34 , A01N43/40 , A61P3/00
CPC分类号： C12Q1/34 , A61K31/445 , C07D211/36 , G01N2333/924
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10.发明授权METHOD FOR TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE THE ACTIVITY OF GANGLIOSIDASES 有权阿尔茨海默氏病药理伴侣的治疗方法来增加GANGLIOSIDASEN的活度
公开(公告)号：EP2490712B1
公开(公告)日：2015-07-08
申请号：EP10825421.0
申请日：2010-10-12
CPC分类号： A61K31/7008 , A61K31/426 , A61K31/429 , A61K31/445 , A61K38/1709 , G06F19/00
摘要： The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.
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