公开(公告)号：EP2819788A2

公开(公告)日：2015-01-07

申请号：EP13754824.4

申请日：2013-02-27

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  PODUST, Vladimir ,  WANG, Chia-Wei ,  MCLAUGHLIN, Bryant ,  SIM, Bee-Cheng ,  DING, Sheng ,  GU, Chen

IPC分类号： B05B5/06

CPC分类号： A61K47/48246 ,  A61K38/24 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07K5/0205

摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

摘要翻译： 本发明涉及延伸的重组多肽（XTEN）组合物，包含与可用于与药理活性有效载体缀合的交联剂连接的XTEN和XTEN的缀合物组合物，制备高纯度XTEN的方法，制备XTEN-接头和XTEN-有效载体缀合物的方法 以及使用XTEN-交联剂和XTEN-有效载体组合物的方法。

公开(公告)号：EP3406347A3

公开(公告)日：2019-02-13

申请号：EP18180908.8

申请日：2013-02-27

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  PODUST, Vladimir ,  WANG, Chia-Wei ,  MCLAUGHLIN, Bryant ,  SIM, Bee-Cheng ,  DING, Sheng ,  GU, Chen

IPC分类号： B05B5/06

摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

公开(公告)号：EP2819788B1

公开(公告)日：2018-08-22

申请号：EP13754824.4

申请日：2013-02-27

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  PODUST, Vladimir ,  WANG, Chia-Wei ,  MCLAUGHLIN, Bryant ,  SIM, Bee-Cheng ,  DING, Sheng ,  GU, Chen

IPC分类号： B05B5/06

CPC分类号： A61K38/24 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07K5/0205

摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

公开(公告)号：EP3406347A2

公开(公告)日：2018-11-28

申请号：EP18180908.8

申请日：2013-02-27

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  PODUST, Vladimir ,  WANG, Chia-Wei ,  MCLAUGHLIN, Bryant ,  SIM, Bee-Cheng ,  DING, Sheng ,  GU, Chen

IPC分类号： B05B5/06

CPC分类号： A61K38/24 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07K5/0205

摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.