公开(公告)号：EP3973982B1

公开(公告)日：2024-07-31

申请号：EP21196378.0

申请日：2018-08-31

IPC分类号： A61K38/24 ,  A61P15/08

CPC分类号： A61K38/24

公开(公告)号：EP4400165A2

公开(公告)日：2024-07-17

申请号：EP24171612.5

申请日：2016-01-28

申请人： Li Galli B.V.

发明人： DE LAAT, Wilhelmus Nicolaas Gerardus Maria ,  VAN DER VAART, Carl Huibert

IPC分类号： A61P13/10

CPC分类号： A61K38/28 ,  A61K9/0036 ,  A61K31/216 ,  A61K31/343 ,  A61K31/4168 ,  A61K31/428 ,  A61K31/465 ,  A61K31/485 ,  A61K31/57 ,  A61K45/06 ,  A61K31/4515 ,  A61K31/4725 ,  A61K31/565 ,  A61M31/002 ,  A61F6/06 ,  A61K38/24 ,  A61P13/02 ,  A61P15/12 ,  A61P15/18 ,  A61P25/04 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P25/34 ,  A61P25/36 ,  A61P5/00 ,  A61P5/24 ,  A61P9/12 ,  A61P3/10

摘要： The present invention relates to a vaginal drug delivery device configured for placement within the vagina, comprising a housing, at least one reservoir comprising a biologically active compound that is not normally administered via the vagina and means for the controlled release of the compound from the reservoir into the vagina. Suitably the vaginal device further comprising means for gathering physiological data of a person carrying the device in her vagina. Alternatively, the vaginal drug delivery device configured for placement within the vagina, comprises a housing and means for gathering physiological data of a person carrying the device in her vagina.

公开(公告)号：EP3406347A2

公开(公告)日：2018-11-28

申请号：EP18180908.8

申请日：2013-02-27

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  PODUST, Vladimir ,  WANG, Chia-Wei ,  MCLAUGHLIN, Bryant ,  SIM, Bee-Cheng ,  DING, Sheng ,  GU, Chen

IPC分类号： B05B5/06

CPC分类号： A61K38/24 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C07K5/0205

摘要： The present invention relates to extended recombinant polypeptide (XTEN) compositions, conjugate compositions comprising XTEN and XTEN linked to cross-linkers useful for conjugation to pharmacologically active payloads, methods of making highly purified XTEN, methods of making XTEN-linker and XTEN-payload conjugates, and methods of using the XTEN-cross-linker and XTEN-payload compositions.

公开(公告)号：EP2635127B1

公开(公告)日：2018-10-17

申请号：EP11838925.3

申请日：2011-11-04

申请人： Genyous Biomed International

发明人： DAO, James ,  GAO, Allen, Chuan ,  GERWICK, William ,  GERWICK, Lena ,  JORDAN, MaryAnn ,  MIKOVITS, Judy ,  OKOUNEVA, Tatiana ,  OROUDJEV, Emin ,  DAO, Jeffrey

IPC分类号： A61K36/074 ,  A61K36/537 ,  A61K36/539 ,  A61K31/165

CPC分类号： A61K36/074 ,  A61K9/2086 ,  A61K31/277 ,  A61K36/537 ,  A61K36/539 ,  A61K38/24 ,  A61K2300/00

摘要： Botanical compositions comprising non-alcoholic organic extracts of Ganoderma lucidum, Salvia miltiorrhiza, and Scutellaria barbata for use in conjunction with bicalutamide therapy fpr cancer therapy, are provided. Methods for treatment or therapy of prostate cancer in a human is provided, the method comprising: administering an effective amount of a botanical composition that is effective for reducing androgen receptor protein expression; and administering concurrently an effective amount of a compound having anti-androgen activity, wherein the concurrent administration of the compound and the botanical composition achieves a therapeutic effect that is more effective than either agent alone.

公开(公告)号：EP3195875B1

公开(公告)日：2018-07-25

申请号：EP17154031.3

申请日：2012-08-08

申请人： Ferring BV

发明人： ARCE, Joan-Carles

IPC分类号： A61K38/24 ,  A61P5/06

CPC分类号： A61K38/24

摘要： Preparations including FSH, for example recombinant FSH, for use in the treatment of infertility.

公开(公告)号：EP3177316A4

公开(公告)日：2018-03-07

申请号：EP15822240

申请日：2015-07-08

申请人： ZIETCHICK RES INSTITUTE LLC

发明人： MOVSAS TAMMY Z

IPC分类号： A61K38/24 ,  A61P27/02

CPC分类号： A61K38/24 ,  A61K9/0048 ,  A61K31/573 ,  A61K31/7105 ,  A61K45/06 ,  A61K39/395 ,  A61K2300/00

摘要： A method for treating ocular-disorders which, involve angiogenesis or neovascularization as part of their pathologic process. These types of retinal disorders can be categorized as (a) retinal vascular disorders (such as diabetic retinopathy, retinal vein occlusions and retinopathy of prematurity), (b) subretinal neovascular disorders (such as neovascular age-related macular degeneration, ocular histoplasmosis, pathologic myopia) (c) intraocular tumors (such as ocular melanoma, ocular lymphoma and retino-blastoma). The treatment for these ocular disorder involves the administration of an effective amount of human chorionic gonadotropin (hCG) antagonists, luteinizing hormone (LH) antagonists or hCG/LH receptor antagonists, optionally in combination with at least one additional bioactive agent.

公开(公告)号：EP3265111A2

公开(公告)日：2018-01-10

申请号：EP16710380.3

申请日：2016-02-29

申请人： The University of Rochester ,  Center for Human Reproduction

发明人： SEN, Aritro ,  GLEICHER, Norbert ,  KUSHNIR, Vitaly, A.

IPC分类号： A61K38/17 ,  A61P15/08

CPC分类号： A61K38/22 ,  A61K31/138 ,  A61K31/7105 ,  A61K38/24 ,  A61K45/06 ,  A61P15/08 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/16 ,  C12N2320/31 ,  A61K2300/00

摘要： The present invention provides compositions and methods for the treatment of subjects with impaired fertility or at risk for impaired fertility. In certain aspects, the invention relates to increasing the level or activity of anti-Mullerian hormone (AMH) in a subject.

公开(公告)号：EP3250183A1

公开(公告)日：2017-12-06

申请号：EP16701812.6

申请日：2016-01-28

申请人： Li Galli B.V.

发明人： DE LAAT, Wilhelmus Nicolaas Gerardus Maria ,  VAN DER VAART, Carl Huibert

IPC分类号： A61K9/00 ,  A61K31/216 ,  A61K38/28 ,  A61K31/343 ,  A61K31/4168 ,  A61K31/428 ,  A61K31/465 ,  A61K31/485 ,  A61K31/57

CPC分类号： A61M31/002 ,  A61F6/06 ,  A61K9/0036 ,  A61K31/216 ,  A61K31/343 ,  A61K31/4168 ,  A61K31/428 ,  A61K31/4515 ,  A61K31/465 ,  A61K31/4725 ,  A61K31/485 ,  A61K31/565 ,  A61K31/57 ,  A61K38/24 ,  A61K38/28 ,  A61K45/06 ,  A61M2205/0216 ,  A61M2205/3303 ,  A61M2205/3553 ,  A61M2205/8206 ,  A61M2210/1475 ,  A61M2230/08 ,  A61M2230/201

摘要： The present invention relates to a vaginal drug delivery device configured for placement within the vagina, comprising a housing, at least one reservoir comprising a biologically active compound that is not normally administered via the vagina and means for the controlled release of the compound from the reservoir into the vagina. Suitably the vaginal device further comprising means for gathering physiological data of a person carrying the device in her vagina. Alternatively, the vaginal drug delivery device configured for placement within the vagina, comprises a housing and means for gathering physiological data of a person carrying the device in her vagina. The invention further relates to oxybutynin for use in the treatment of urinary and bladder problems, in particular urge incontinence, wherein oxybutynin is administered to a person in need of treatment by means of the vaginal device, and to other therapeutic compounds that are administered via the vaginal device for use in their corresponding indications.

公开(公告)号：EP3243518A1

公开(公告)日：2017-11-15

申请号：EP17169931.7

申请日：2017-05-08

申请人： Gionas S.r.l.

发明人： MAGGIONI, Cristina

IPC分类号： A61K35/00 ,  A61K35/54 ,  A61P15/00

CPC分类号： A61K35/54 ,  A61K35/00 ,  A61K38/24

摘要： The present invention relates to follicular fluid for use in in vitro fertilization, where said use comprises introducing follicular fluid in the uterus in one or more administrations during a time period comprised between six days before embryo transfer and the transfer day itself.

摘要翻译： 本发明涉及用于体外受精的滤泡液，其中所述用途包括在胚胎移植前六天和移植天本身之间的一段时间内在一次或多次施用中将卵泡液引入子宫中。

公开(公告)号：EP2531521B1

公开(公告)日：2017-09-06

申请号：EP11740281.8

申请日：2011-02-02

申请人： Amano Enzyme USA., Ltd. ,  Amano Enzyme, Inc.

发明人： JOLLY, James, F. ,  IDO, Horoki ,  MATSUBARA, Hirotaka ,  TAKAHASHI, Tetsuya ,  NISHIO, Kyoichi

IPC分类号： A61K38/48 ,  A61P1/00 ,  A61P1/14

CPC分类号： A61K38/4886 ,  A61K38/1703 ,  A61K38/2242 ,  A61K38/24 ,  A61K38/43 ,  A61K38/482 ,  A61K38/4873 ,  C12Y304/21063 ,  C12Y304/22002 ,  C12Y304/24039 ,  A61K2300/00