公开(公告)号：EP2470670A1

公开(公告)日：2012-07-04

申请号：EP10814048.4

申请日：2010-08-02

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  SILVERMAN, Joshua ,  STEMMER, Willem, Peter ,  WANG, Chia-Wei ,  SPINK, Benjamin ,  GEETHING, Nathan, Carl ,  TO, Wayne

IPC分类号： C12P21/04 ,  A61K38/00

CPC分类号： C12N9/644 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/50 ,  C12N9/6437 ,  C12N15/70 ,  C12Y304/21022

摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

公开(公告)号：EP2470559B1

公开(公告)日：2017-03-22

申请号：EP10814049.2

申请日：2010-08-02

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  SILVERMAN, Joshua ,  STEMMER, Willem, Peter ,  WANG, Chia-wei ,  SPINK, Benjamin ,  GEETHING, Nathan, Carl ,  TO, Wayne

IPC分类号： C12N15/57 ,  C12N15/62 ,  C12N9/64 ,  A61P7/04 ,  A61K38/48

CPC分类号： C12N9/644 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/50 ,  C12N9/6437 ,  C12N15/70 ,  C12Y304/21022

摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

公开(公告)号：EP2470559A1

公开(公告)日：2012-07-04

申请号：EP10814049.2

申请日：2010-08-02

申请人： Amunix Operating Inc.

发明人： SCHELLENBERGER, Volker ,  SILVERMAN, Joshua ,  STEMMER, Willem, Peter ,  WANG, Chia-wei ,  SPINK, Benjamin ,  GEETHING, Nathan, Carl ,  TO, Wayne

IPC分类号： C07K14/475

CPC分类号： C12N9/644 ,  A61K38/00 ,  C07K14/001 ,  C07K2319/00 ,  C07K2319/31 ,  C07K2319/50 ,  C12N9/6437 ,  C12N15/70 ,  C12Y304/21022

摘要： The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.

摘要翻译： 本发明涉及组合物，其包括连接至延长重组多肽（XTEN）因子VII凝血因子，分离的核酸编码的组合物和载体和含同样的宿主细胞中，且在治疗凝血因子相关的制造和使用搜索组合物的方法 疾病，紊乱和条件。