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10 条记录 (耗时 0.014 秒)

    Pharmaceutical composition containing decoy and method of using the same
    3.
    发明公开
    Pharmaceutical composition containing decoy and method of using the same 有权
    带有诱饵和使用的方法的药物组合物

    公开(公告)号：EP1690544A3

    公开(公告)日：2012-03-07

    申请号：EP06004446.8

    申请日：2002-02-06

    申请人： AnGes MG, Inc.

    发明人： Morishita, Ryuichi ,  Aoki, Motokuni ,  Ogihara, Toshio ,  Kaneda, Yasufumi ,  Nakamura, Hiroshige

    IPC分类号： A61K48/00 ,  A61K31/711 ,  A61K9/06 ,  A61K47/06 ,  A61K47/10 ,  A61P17/00 ,  A61P17/04 ,  A61K38/17

    CPC分类号： A61K31/711 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/13

    摘要： A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least one decoy may be selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The at least one decoy may be an oligonucleotide including at least two decoys bonded to each other, the at least two decoys being selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The skin disease may be atopic dermatitis, psoriasis vulgaris, contact dermatitis, keloid, bedsore, ulcerative colitis, orCrohn's disease.

    摘要翻译： 针对皮肤病进行处置的药物组合物，所述药物组合物包含至少一个诱饵和药学上可接受的载体。 所述至少一个诱饵可以选自NFκB的诱饵的诱饵中选择，一个STAT-1，GATA-3诱饵，一个STAT-6诱饵，诱饵AP-1和在ETS诱饵。 诱饵至少一个诱饵可以是至少两种寡核苷酸包含在键合到海誓山盟诱饵，选自一个NFκB的诱饵被选择该至少两个诱饵，一个STAT-1，GATA-3诱饵， 一个STAT-6诱饵，诱饵AP-1和在ETS诱饵。 皮肤疾病可能是特应性皮炎，寻常型银屑病，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎或克罗恩病。

    Pharmaceutical composition containing decoy and method of using the same
    6.
    发明公开
    Pharmaceutical composition containing decoy and method of using the same 有权
    带有诱饵和使用的方法的药物组合物

    公开(公告)号：EP1690544A2

    公开(公告)日：2006-08-16

    申请号：EP06004446.8

    申请日：2002-02-06

    申请人： Anges MG Inc.

    发明人： Morishita, Ryuichi ,  Aoki, Motokuni ,  Ogihara, Toshio ,  Kaneda, Yasufumi ,  Nakamura, Hiroshige

    IPC分类号： A61K31/711 ,  A61K38/17 ,  A61P17/00 ,  A61P17/04

    CPC分类号： A61K31/711 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/13

    摘要： A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least one decoy may be selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The at least one decoy may be an oligonucleotide including at least two decoys bonded to each other, the at least two decoys being selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The skin disease may be atopic dermatitis, psoriasis vulgaris, contact dermatitis, keloid, bedsore, ulcerative colitis, orCrohn's disease.

    摘要翻译： 针对皮肤病进行处置的药物组合物，所述药物组合物包含至少一个诱饵和药学上可接受的载体。 所述至少一个诱饵可以选自NF-ºB诱饵的诱饵中选择，一个STAT-1，GATA-3诱饵，一个STAT-6诱饵，诱饵AP-1和在ETS诱饵。 诱饵的至少一个诱饵可以是寡核苷酸的包括至少两个诱饵彼此键合，被选自NF-ºB诱饵，一个STAT-1，GATA-3诱饵，一个所选择的至少两个诱饵 STAT-6诱饵，诱饵AP-1和在ETS诱饵。 皮肤疾病可能是特应性皮炎，寻常型银屑病，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎，orCrohn病。

    Pharmaceutical composition for treatment of angiogenesis-dependent conditions
    10.
    发明公开
    Pharmaceutical composition for treatment of angiogenesis-dependent conditions 有权
    药剂师Zusammensetzung zur Behandlung der angiogenese-abhängigenZuständen

    公开(公告)号：EP1391514A1

    公开(公告)日：2004-02-25

    申请号：EP03018151.5

    申请日：2003-08-08

    申请人： AnGes MG, Inc.

    发明人： Morishita, Ryuichi ,  Namba, Tsunetatsu ,  Ogihara, Toshio

    IPC分类号： C12N15/53 ,  A61K48/00 ,  A61P9/10 ,  A61P17/02

    CPC分类号： A61K48/0016 ,  A61K38/44 ,  A61K48/00 ,  C12Y114/13039

    摘要： The feasibility of gene therapy using NO synthase (NOS) to treat peripheral arterial disease was examined. According to the present invention, transfection of NOS vector resulted in a significant increase in blood flow and capillary density. Thus, the present invention provides use of a NOS gene for preparing a naked DNA vector for treating or preventing angiogenesis-dependent conditions.

    摘要翻译： 检查使用NO合酶（NOS）治疗外周动脉疾病的基因治疗的可行性。 根据本发明，转染NOS载体导致血流量和毛细血管密度显着增加。 因此，本发明提供了用于制备用于治疗或预防血管生成依赖性病症的裸DNA载体的NOS基因的用途。