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    Pharmaceutical composition containing decoy and method of using the same
    4.
    发明公开
    Pharmaceutical composition containing decoy and method of using the same 有权
    带有诱饵和使用的方法的药物组合物

    公开(公告)号：EP1690544A3

    公开(公告)日：2012-03-07

    申请号：EP06004446.8

    申请日：2002-02-06

    申请人： AnGes MG, Inc.

    发明人： Morishita, Ryuichi ,  Aoki, Motokuni ,  Ogihara, Toshio ,  Kaneda, Yasufumi ,  Nakamura, Hiroshige

    IPC分类号： A61K48/00 ,  A61K31/711 ,  A61K9/06 ,  A61K47/06 ,  A61K47/10 ,  A61P17/00 ,  A61P17/04 ,  A61K38/17

    CPC分类号： A61K31/711 ,  A61K38/1709 ,  C12N15/113 ,  C12N2310/13

    摘要： A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least one decoy may be selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The at least one decoy may be an oligonucleotide including at least two decoys bonded to each other, the at least two decoys being selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The skin disease may be atopic dermatitis, psoriasis vulgaris, contact dermatitis, keloid, bedsore, ulcerative colitis, orCrohn's disease.

    摘要翻译： 针对皮肤病进行处置的药物组合物，所述药物组合物包含至少一个诱饵和药学上可接受的载体。 所述至少一个诱饵可以选自NFκB的诱饵的诱饵中选择，一个STAT-1，GATA-3诱饵，一个STAT-6诱饵，诱饵AP-1和在ETS诱饵。 诱饵至少一个诱饵可以是至少两种寡核苷酸包含在键合到海誓山盟诱饵，选自一个NFκB的诱饵被选择该至少两个诱饵，一个STAT-1，GATA-3诱饵， 一个STAT-6诱饵，诱饵AP-1和在ETS诱饵。 皮肤疾病可能是特应性皮炎，寻常型银屑病，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎或克罗恩病。

    THERAPEUTIC AGENT FOR PERIODONTAL DISEASE AND ALVEOLAR BONE LOSS DUE TO SURGERY
    6.
    发明公开
    THERAPEUTIC AGENT FOR PERIODONTAL DISEASE AND ALVEOLAR BONE LOSS DUE TO SURGERY 审中-公开
    治疗师GEGEN PARODONTALERKRANKUNGEN UND DEVEOLAR-KNOCHENVERLUST DURCH OPERATION

    公开(公告)号：EP2127681A1

    公开(公告)日：2009-12-02

    申请号：EP08711312.2

    申请日：2008-02-15

    申请人： AnGes MG, Inc.

    发明人： MORISHITA, Ryuichi ,  NAKAGAMI, Hironori ,  SHIMIZU, Hideo

    IPC分类号： A61K48/00 ,  A61K31/713 ,  A61K45/00 ,  A61K47/42 ,  A61P1/02 ,  A61P19/08 ,  A61P29/00

    CPC分类号： A61K9/0063 ,  A61K31/713 ,  A61K48/00 ,  C12N15/113 ,  C12N2310/13

    摘要： By suppressing transcription activation by NFκB, the present invention was demonstrated to suppress alveolar bone resorption in periodontal disease models, and promote restoration of alveolar bone in periodontal disease-caused bone defect models. Therefore, the present invention provides agents for treating, preventing, and improving periodontal diseases and alveolar bone defects caused by surgical operations, said agents comprising as an active ingredient, a NFκB decoy or such that suppresses the transcription activity of NFκB.

    摘要翻译： 通过抑制NFκB的转录激活，本发明被证明能抑制牙周病模型中的牙槽骨吸收，促进牙周病引起的骨缺损模型中牙槽骨的恢复。 因此，本发明提供了用于治疗，预防和改善由外科手术引起的牙周病和牙槽骨缺损的药剂，所述药物包含作为活性成分的抑制NFκB转录活性的NFκB诱饵。