公开(公告)号：EP4176900A1

公开(公告)日：2023-05-10

申请号：EP22162381.2

申请日：2016-04-15

申请人： AnaptysBio, Inc.

发明人： Bowers, Peter ,  McKnight, Andrew John ,  King, David J. ,  Londei, Marco

IPC分类号： A61K39/395 ,  A61P9/10 ,  A61P29/00 ,  A61P37/06

摘要： The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that bind to a protein encoded by the interleukin 36 receptor (IL-36R). The invention provides an IL-36R-binding agent that comprises the aforementioned immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide. The invention also provides related vectors, compositions, and methods of using the IL-36R-binding agent to treat a disorder or disease that is responsive to IL-36R inhibition, such as cancer, an infectious disease, or an autoimmune disease.