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    ANTI-COMPLEMENT FACTOR C1S ANTIBODIES AND USES THEREOF
    3.
    发明公开
    ANTI-COMPLEMENT FACTOR C1S ANTIBODIES AND USES THEREOF 审中-公开
    抗补体因子C1S抗体及其用途

    公开(公告)号：EP2997045A2

    公开(公告)日：2016-03-23

    申请号：EP14798295.3

    申请日：2014-05-15

    申请人： Annexon, Inc.

    发明人： ROSENTHAL, Arnon ,  LEVITEN, Michael

    IPC分类号： C07K16/40

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6854

    摘要： The present invention relates generally to the generation and characterization of neutralizing anti-C1s monoclonal antibodies. The invention further relates to the use of such anti-C1s antibodies in the detection of complement factors of the classical complement activation pathway, such as C1s. Additionally, the antibodies of this disclosure are useful for the diagnosis and treatment of disorders associated with an increased activation of the classical complement pathway, in particular autoimmune disorders and neurodegenerative diseases, including neurodegenerative diseases with synapse loss, such as Alzheimer's Disease. Methods of treatment of autoimmune and neurodegenerative diseases are also provided.

    摘要翻译： 本发明一般涉及中和抗C1s单克隆抗体的产生和表征。 本发明进一步涉及这种抗C1s抗体在检测经典补体激活途径的补体因子例如C1s中的用途。 另外，本公开的抗体可用于诊断和治疗与经典补体途径的激活增加相关的病症，特别是自身免疫病症和神经退行性疾病，包括具有突触丧失的神经变性疾病，例如阿尔茨海默病。 还提供了治疗自身免疫疾病和神经退行性疾病的方法。

    ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF
    4.
    发明公开
    ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：EP4252769A2

    公开(公告)日：2023-10-04

    申请号：EP23174927.6

    申请日：2014-07-09

    申请人： Annexon, Inc.

    发明人： ROSENTHAL, Arnon ,  LEVITEN, Michael

    IPC分类号： A61K39/00

    摘要： The present invention relates to an isolated anti-Clq antibody comprising a light chain comprising a light chain variable domain and a heavy chain comprising a heavy chain variable domain, wherein: (i) the light chain variable domain comprises the HVR-L1 comprising the amino acid sequence of SEQ ID NO:5, HVR-L2 comprising the amino acid sequence of SEQ ID NO:6, and HVR-L3 comprising the amino acid sequence of SEQ ID NO:7; and (ii) the heavy chain variable domain comprises the HVR-H1 comprising the amino acid sequence of SEQ ID NO:9, HVR-H2 comprising the amino acid sequence of SEQ ID NO:10, and HVR-H3 comprising the amino acid sequence of SEQ ID NO:11; and wherein the antibody has a dissociation constant (KD) for human Clq of less than 1nM.

    ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF
    10.
    发明公开
    ANTI-COMPLEMENT FACTOR C1Q ANTIBODIES AND USES THEREOF 审中-公开

    公开(公告)号：EP4252769A3

    公开(公告)日：2023-11-29

    申请号：EP23174927.6

    申请日：2014-07-09

    申请人： Annexon, Inc.

    发明人： ROSENTHAL, Arnon ,  LEVITEN, Michael

    IPC分类号： A61P11/06 ,  C07K16/18 ,  A61K39/00

    摘要： The present invention relates to an isolated anti-Clq antibody comprising a light chain comprising a light chain variable domain and a heavy chain comprising a heavy chain variable domain, wherein: (i) the light chain variable domain comprises the HVR-L1 comprising the amino acid sequence of SEQ ID NO:5, HVR-L2 comprising the amino acid sequence of SEQ ID NO:6, and HVR-L3 comprising the amino acid sequence of SEQ ID NO:7; and (ii) the heavy chain variable domain comprises the HVR-H1 comprising the amino acid sequence of SEQ ID NO:9, HVR-H2 comprising the amino acid sequence of SEQ ID NO:10, and HVR-H3 comprising the amino acid sequence of SEQ ID NO:11; and wherein the antibody has a dissociation constant (KD) for human Clq of less than 1nM.