公开(公告)号：EP0811689B1

公开(公告)日：2002-06-12

申请号：EP96938223.3

申请日：1996-11-15

申请人： Antibioticos, S.A.

发明人： RODRIGUEZ OTERO, Carmelita ,  MORENO VALLE, Miguel Angel ,  LOPEZ NIETO, Manuel Jesús ,  COLLADOS DE LA VIEJA, Alfonso Juan ,  VITALLER ALBA, Alejandro

IPC分类号： C12P17/18

CPC分类号： C12P17/188 ,  Y10S435/886

摘要： A batch fermentation is carried out continuously or semicontinuously using strains of Streptomyces clavuligerus ATCC 27064 or mutants thereof. The fermentation process is carried out with a strict control of the soluble phosphate in the medium, both at the beginning and throughout the process. As a carbon source, lipids, preferably triglycerides can be used. Substantial increases in the production of the antibiotic are obtained.

公开(公告)号：EP0811689A1

公开(公告)日：1997-12-10

申请号：EP96938223.3

申请日：1996-11-15

申请人： Antibioticos, S.A.

发明人： RODRIGUEZ OTERO, Carmelita ,  MORENO VALLE, Miguel Angel ,  LOPEZ NIETO, Manuel Jesús ,  COLLADOS DE LA VIEJA, Alfonso Juan ,  VITALLER ALBA, Alejandro

IPC分类号： C12P17/18

CPC分类号： C12P17/188 ,  Y10S435/886

摘要： A batch fermentation is carried out continuously or semicontinuously using strains of Streptomyces clavuligerus ATCC 27064 or mutants thereof. The fermentation process is carried out with a strict control of the soluble phosphate in the medium, both at the beginning and throughout the process. As a carbon source, lipids, preferably triglycerides can be used. Substantial increases in the production of the antibiotic are obtained.

摘要翻译： 使用Streptomyces clavuligerus ATCC 27064或其突变体的菌株连续或半连续地进行分批发酵。 在开始和整个过程中，对培养基中可溶性磷酸盐的严格控制进行发酵过程。 作为碳源，可以使用脂质，优选甘油三酸酯。 获得抗生素生产的实质性增加。