公开(公告)号：EP2201518A1

公开(公告)日：2010-06-30

申请号：EP08832405.8

申请日：2008-09-19

申请人： Aperio Technologies, Inc.

发明人： SOENKSEN, Dirk G. ,  PERZ, Cindy

IPC分类号： G06Q50/00

CPC分类号： G06K9/00127 ,  G02B21/241 ,  G06K9/0014 ,  G06T5/003 ,  G06T5/50 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024

摘要： An improved diagnostic resolution of digital slide images is obtained by scanning a first digital slide image at diagnostic resolution that is then deconvolved into separate images with one stain per image. The single stain images are then enhanced with image adjustments and/or processed with image analysis algorithms. The resulting single image data sets from the image analysis algorithms can then be stored. Additionally, the resulting enhanced single images can be recombined into a second digital slide image at diagnostic resolution that is also enhanced.

公开(公告)号：EP2143030A1

公开(公告)日：2010-01-13

申请号：EP08780568.5

申请日：2008-04-25

申请人： Aperio Technologies, Inc.

发明人： SOENKSEN, Dirk G. ,  ZIRKER-SMITH, Kathy ,  EICHHORN, Ole

IPC分类号： G06F19/00

CPC分类号： G16H80/00 ,  G06F19/00 ,  G06F19/321 ,  G16H50/50

摘要： Systems and methods are provided to facilitate consultations between a referral source (e.g., labs, pathologists and patients) and a consultant (e.g., pathologist, radiologist, or other digital image analyst). Links between the various referral sources and consultants are established through a scanning center via a data communication network such as the Internet. The referral source sends a slide to the scanning center where the corresponding digital slide is posted for review and analysis by the consultant. Upon completion of the analysis and report, a digital slide conference is conducted through the scanning center that provides a venue for direct communication regarding the consultation. The scanning center may also facilitate payment from the referral source to the consultant.

公开(公告)号：EP2344864A2

公开(公告)日：2011-07-20

申请号：EP09822817.4

申请日：2009-10-23

申请人： Aperio Technologies, Inc.

发明人： NAJMABADI, Peyman ,  CRANDALL, Gregory J. ,  STEARRETT, Aaron Alan ,  SOENKSEN, Dirk G. ,  LEE, Christopher Adam ,  PERZ, Cynthia

IPC分类号： G01N21/64 ,  G01N21/85 ,  G01B11/00 ,  G01N35/00

CPC分类号： G02B21/0084 ,  G01N21/64 ,  G01N21/6458 ,  G01N2021/6471 ,  G02B21/00 ,  G02B21/002 ,  G02B21/0076 ,  G02B21/16 ,  G06K9/00134 ,  G06T7/30 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30024 ,  H04N5/3692

摘要： A whole slide fluorescence digital pathology system is provided that uses a monochrome TDI line scan camera, which is particularly useful in fluorescence scanning where the signal is typically much weaker than in brightfield microscopy. The system uses oblique brightfield illumination for fast and accurate tissue finding and employs a unique double sweep focus scoring and objective lens height averaging technique to identify focus points and create a focus map that can be followed during subsequent scanning to provide autofocusing capability. The system also scans and analyzes image data to determine the optimal line rate for the TDI line scan camera to use during subsequent scanning of the digital slide image and it also creates a light profile to compensate for loss of illumination light due to roll off.

摘要翻译： 一种用于创建荧光显微镜样品的连续数字图像的系统。 在一个实施例中，系统包括宏观照相机和时间延迟积分（TDI）线扫描照相机。 该系统还可以包括电动台，照明模块，光源，激发滤光器，物镜，发射滤光器以及配置成组装荧光显微镜样本的多个数字图像的至少一个处理器， 由TDI线扫描相机生成的荧光显微镜样品的至少一部分的连续数字图像。

公开(公告)号：EP2153401A1

公开(公告)日：2010-02-17

申请号：EP08747494.6

申请日：2008-05-02

申请人： Aperio Technologies, Inc.

发明人： SOENKSEN, Dirk G. ,  ZIRKER-SMITH, Kathy

IPC分类号： G06Q50/00 ,  G06F19/00

CPC分类号： G06K9/00127 ,  G02B21/365 ,  G06F19/00 ,  G06F19/30 ,  G06K9/00134 ,  G06K9/03 ,  G06K9/033 ,  G06Q50/22 ,  G06T5/001 ,  G06T7/0002 ,  G06T7/0012 ,  G06T2207/10024 ,  G06T2207/10056 ,  G06T2207/30024

摘要： Systems and methods for improving quality assurance in pathology using automated quality assessment and digital image enhancements on digital slides prior to analysis by the pathologist are provided. A digital pathology system (slide scanning instrument and software) creates, assesses and improves the quality of a digital slide. The improved digital slide image has a higher image quality that results in increased efficiency and accuracy in the analysis and diagnosis of such digital slides when they are reviewed on a monitor by a pathologist. These improved digital slides yield a more objective diagnosis than reading the corresponding glass slide under a microscope.