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1.发明公开SYSTEMS AND METHODS FOR CREATING AND VIEWING THREE DIMENSIONAL VIRTUAL SLIDES 审中-公开系统和方法生成和查看三维虚拟幻灯片
公开(公告)号：EP1756750A4
公开(公告)日：2010-10-20
申请号：EP05754489
申请日：2005-05-27
发明人： EICHHORN OLE , CRANDALL GREG J , HASHAGEN STEVEN , SOENKSEN DIRK G , WRENN MARK
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/0495
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
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公开(公告)号：EP2035976A2
公开(公告)日：2009-03-18
申请号：EP07840329.2
申请日：2007-06-29
发明人： EICHHORN, Ole
CPC分类号： G06F17/30277 , G06F17/30106 , G06F17/3028 , Y10S707/915 , Y10S707/966
摘要： Images created by one or more image acquisition devices are initially stored in remote data bases at one or more remote or satellite locations and copies of the images are subsequently transferred to a central server at a central storage location over a network and stored in a central data base. A common catalog listing local image files stored at the central data base and remote image files stored at one or more remote data bases is stored at the central location and is accessed by users to search for images. User requests for images associated with local image files result in transfer of the requested images by the central server to the user. User requests for images associated with remote image files are relayed by the central server to the associated remote location, and the requested images are then relayed to the user from the remote location via the central server.
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公开(公告)号：EP1851726A2
公开(公告)日：2007-11-07
申请号：EP06719599.0
申请日：2006-01-27
发明人： EICHHORN, Ole
IPC分类号： G06T15/70
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images are provided. An image library module provides access to the imagery data in a 3D virtual slide and constructs 3D image objects that are coextensive with the 3D virtual slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D virtual slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
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4.发明公开
公开(公告)号：EP1597695A4
公开(公告)日：2007-06-06
申请号：EP04715770
申请日：2004-02-27
发明人： EICHHORN OLE , BRUMME ANNE
IPC分类号： G02B21/26 , G02B21/32 , G06F17/30 , G06K20060101 , G06K9/00
CPC分类号： H04L65/403 , G02B21/26 , G02B21/32 , G06F3/1454 , G06F17/241 , G06F17/30905 , G06F19/321 , G06Q50/24
摘要： Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.
摘要翻译： 虚拟幻灯片图像数据和对应信息存储在虚拟幻灯片服务器上的数据存储区域中。 客户端查看器以特定分辨率请求图像数据。 图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。 然后将图像数据发送到客户端查看器。 在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。
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5.发明公开SYSTEM AND METHOD TO DETERMINE SLIDE QUALITY OF A DIGITIZED MICROSCOPE SLIDE 审中-公开系统VERFAHREN ZUR BESTIMMUNG DERGLEITQUALITÄTEINES DIGITALISIERTEN MIKROSKOPSCHIEBERS
公开(公告)号：EP2577602A4
公开(公告)日：2015-10-28
申请号：EP11790514
申请日：2011-06-03
发明人： EICHHORN OLE , PERZ CINDY
CPC分类号： G06K9/00127 , G06T7/0004 , G06T2207/10056 , G06T2207/20021 , G06T2207/30024 , G06T2207/30168 , H04N19/60 , H04N19/86
摘要： A system that determines the quality of a digital microscope slide by analyzing digital slide images based on complexity and spatial frequencies. An example embodiment detailed in the application may provide visual feedback on the whole slide quality by overlaying the image with a color coded "heat map" of local area quality. A user provided with the overlap image may obtain both an absolute quality measurement for the whole image and quickly identity the quality variability within the slide.
摘要翻译： 通过基于复杂性和空间频率分析数字幻灯片图像来确定数字显微镜幻灯片的质量的系统。 应用中详细描述的示例实施例可以通过用局部区域质量的颜色编码的“热图”覆盖图像来提供关于整个幻灯片质量的视觉反馈。 提供重叠图像的用户可以获得整个图像的绝对质量测量，并且快速识别幻灯片内的质量变异性。
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公开(公告)号：EP1599824A4
公开(公告)日：2008-02-27
申请号：EP04711231
申请日：2004-02-13
发明人： EICHHORN OLE , SOENKSEN DIRK G
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization ('VQ') of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (TMAs).
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7.发明公开SYSTEM AND METHOD FOR DATA MANAGEMENT IN A LINEAR-ARRAY-BASED MICROSCOPE SLIDE SCANNER 审中-公开基于线性阵列的系统和方法进行数据管理在显微镜载玻片扫描仪
公开(公告)号：EP1784763A1
公开(公告)日：2007-05-16
申请号：EP04782757.1
申请日：2004-09-01
IPC分类号： G06K9/00
CPC分类号： G02B21/008 , G02B21/367 , G06T3/4038 , G06T7/32 , G06T2207/30004
摘要： A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individual addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and scaleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepathology, microscopy education, and the analysis of high value specimens such as tissue arrays.
摘要翻译： 用于处理，存储和观看非常大的图像数据的数据管理系统和方法也正在迅速由提供了一种基于线性阵列显微镜载玻片扫描仪产生。 该系统接收，处理和存储影像数据由基于线性阵列显微镜载玻片扫描仪以每分钟约3 GB生产。 数据被接收为一系列重叠图像条纹的和合并成一个无缝和连续的基线图像。 基线图像被逻辑映射到区域的多元性没有被单独寻址，以便于基线图像的查看和操作。 数据管理系统中允许的图像数据压缩，同时扫描和捕获新的图像条纹。 这有利地消除了与存储未压缩图像的条纹相关的开销。 图像压缩，从而创建中间电平的图像，从而组织基线图像到由被称为虚拟载玻片可变电平的金字塔结构。 数据管理系统可以有效图像条纹转换成高质量的虚拟切片确实允许快速摇摄和图像缩放在雅舞蹈查看软件与个人解决的地区。 的虚拟载片通过在算法框架，以便允许有效的处理。 数据管理系统是有效的，并且收费可扩展的，采用标准图像文件格式，并支持在较佳的应用中的使用虚拟幻灯片：诸如远程医疗，远程病理学，显微镜教育，和高价值的标本的分析：如组织阵列。
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公开(公告)号：EP1631872A2
公开(公告)日：2006-03-08
申请号：EP04715734.2
申请日：2004-02-27
发明人： EICHHORN, Ole , OLSON, Allen
IPC分类号： G06F1/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T1/00 , G06T2207/10056 , G06T2207/20016
摘要： A system and method for processing and analyzing virtual microscopy digital images ("virtual slides") is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of virtual slides. The algorithm server executes a selected routine on an identified virtual slide and provides the resulting data. The virtual slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view virtual slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of virtual slides and demonstrations of image processing algorithms.
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公开(公告)号：EP1597695A2
公开(公告)日：2005-11-23
申请号：EP04715770.6
申请日：2004-02-27
发明人： EICHHORN, Ole , BRUMME, Anne
IPC分类号： G06K9/00
CPC分类号： H04L65/403 , G02B21/26 , G02B21/32 , G06F3/1454 , G06F17/241 , G06F17/30905 , G06F19/00 , G06F19/321 , G06Q50/24
摘要： Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.
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公开(公告)号：EP2036003A4
公开(公告)日：2011-11-16
申请号：EP07799195
申请日：2007-06-29
发明人： EICHHORN OLE
CPC分类号： G06F17/30244 , G06F17/3028 , G06F19/321 , G06T3/40 , G06T7/0012 , G06T7/30 , G06T2207/20021 , G06T2207/30004
摘要： Systems and methods that acquire digital slides and other large images and store these images into commercially available PACS systems using DICOM-standard messaging are provided. A digital slide or other large two-dimensional image is acquired and each separate resolution level of the digital slide or large image is divided into a series of regions that are each identified as a DICOM image. All of the regions at the same resolution in the digital slide or other large image are collectively identified as a DICOM series. A plurality of DICOM series, representing multiple resolution levels in a digital slide are collectively identified and stored as a DICOM study.
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