公开(公告)号：EP1633396B1

公开(公告)日：2011-07-27

申请号：EP04752743.7

申请日：2004-05-20

申请人： Applied Molecular Evolution, Inc.

发明人： WATKINS, Jeffry, D. ,  DAVIES, Julian ,  MARQUIS, David, M. ,  ALLAN, Barrett, W. ,  ONDEK, Brian

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/30 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07K16/2887 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92

摘要： The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).