公开(公告)号：EP1776384A2

公开(公告)日：2007-04-25

申请号：EP05773014.5

申请日：2005-07-18

申请人： Applied Molecular Evolution Inc.

发明人： ALLAN, Barrett ,  JIANG, Weidong ,  TANG, Ying ,  WATKINS, Jeffry Dean

IPC分类号： C07K16/00 ,  C12N15/12 ,  C12N5/10 ,  A61K39/395

CPC分类号： C07K16/2887 ,  C07K16/2896 ,  C07K2317/52 ,  C07K2317/732 ,  C07K2317/734

摘要： The present invention provides polypeptides, particularly therapeutic antibodies, comprising a novel, variant Fc region. Furthermore the invention provides variant Fc regions which confer an altered effector function or altered serum half life upon a polypeptide to which it is operable attached.