公开(公告)号：EP1437139A3

公开(公告)日：2004-09-29

申请号：EP04004524.7

申请日：1994-09-12

申请人： ARCH DEVELOPMENT CORPORATION

发明人： Grdina, David

IPC分类号： A61K31/661

CPC分类号： C07F9/1651 ,  A61K31/13 ,  A61K31/185 ,  A61K31/425 ,  A61K31/66 ,  A61K31/661 ,  A61K45/06 ,  C07C323/25 ,  C07H5/10 ,  C07H9/06 ,  A61K2300/00

摘要： A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothiate metabolite selected from the group consisting S-2-(3-aminopropylamino)ethylphosphorothioic acid, S-1-(aminoethyl) phosphorothioic acid, S-[2-(3-methylaminopropyl) aminoethyl] phosphorothioate acid, S-2-(4-aminobu-lamino) ethylphosphorothioic acid, 3-[(2-mercaptoethyl) amino] propionamide p-toluenesulfonate, S-1-(2-hydroxy-3-amino) propyl phosphorothioic acid, 2-[3-(methylamino) propylamino] ethanethiol, 2-(aminopropylamino)ethanethiol, S-2-(5-aminopentylamino) ethyl phosphorothioic acid, 1 [3-(3-(aminopropyl) thiazolidin-2-Y1]-D-gluco-1,2,3,4,5 pentanepentol dihydrochloride and N,N'-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamme to the mammal before or up to 3 hours after irradiation.

公开(公告)号：EP1437139B1

公开(公告)日：2008-07-16

申请号：EP04004524.7

申请日：1994-09-12

申请人： Arch Development Corporation

发明人： Grdina, David

IPC分类号： A61K31/661 ,  A61P39/00

CPC分类号： C07F9/1651 ,  A61K31/13 ,  A61K31/185 ,  A61K31/425 ,  A61K31/66 ,  A61K31/661 ,  A61K45/06 ,  C07C323/25 ,  C07H5/10 ,  C07H9/06 ,  A61K2300/00

公开(公告)号：EP1437139A2

公开(公告)日：2004-07-14

申请号：EP04004524.7

申请日：1994-09-12

申请人： ARCH DEVELOPMENT CORPORATION

发明人： Grdina, David

IPC分类号： A61K31/661

CPC分类号： C07F9/1651 ,  A61K31/13 ,  A61K31/185 ,  A61K31/425 ,  A61K31/66 ,  A61K31/661 ,  A61K45/06 ,  C07C323/25 ,  C07H5/10 ,  C07H9/06 ,  A61K2300/00

摘要： A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothiate metabolite selected from the group consisting S-2-(3-aminopropylamino)ethylphosphorothioic acid, S-1-(aminoethyl) phosphorothioic acid, S-[2-(3-methylaminopropyl) aminoethyl] phosphorothioate acid, S-2-(4-aminobu-lamino) ethylphosphorothioic acid, 3-[(2-mercaptoethyl) amino] propionamide p-toluenesulfonate, S-1-(2-hydroxy-3-amino) propyl phosphorothioic acid, 2-[3-(methylamino) propylamino] ethanethiol, 2-(aminopropylamino)ethanethiol, S-2-(5-aminopentylamino) ethyl phosphorothioic acid, 1 [3-(3-(aminopropyl) thiazolidin-2-Y1]-D-gluco-1,2,3,4,5 pentanepentol dihydrochloride and N,N'-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamme to the mammal before or up to 3 hours after irradiation.

摘要翻译： 一种用于防止哺乳动物细胞受辐照诱导的突变损伤的方法，包括给予硫代磷酸酯或磷酸酯代谢物，所述代谢物选自S-2-（3-氨基丙基氨基）乙基硫代磷酸，S-1-（氨基乙基）硫代磷酸，S-Ä2 - （3-甲基氨基丙基）氨基乙基硫代磷酸酯，S-2-（4-氨基丁氨基）乙基硫代硫酸，3-（2-巯基乙基）氨基丙酰胺对甲苯磺酸酯，S-1-（2-羟基-3-氨基 ）丙基硫代磷酸，2-Ä3-（甲基氨基）丙基氨基乙硫醇，2-（氨丙基氨基）乙硫醇，S-2-（5-氨基戊基氨基）乙基硫代磷酸，1Ä3-（3-（氨基丙基）噻唑烷-2-Y1- D-吡喃葡萄糖-1,2,3,4,5戊戊酮二盐酸盐和N，N' - （二硫代二-2,1-乙二基）双-1,3-丙二醇在照射前或3小时之前给予哺乳动物。