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公开(公告)号：EP1794327B1
公开(公告)日：2016-11-30
申请号：EP05797971.8
申请日：2005-09-14
CPC分类号： C07K14/005 , A61K39/21 , A61K2039/5154 , A61K2039/5156 , C12N7/00 , C12N2740/16041 , C12N2740/16234 , C12N2740/16334 , C12Q1/703
摘要： This in invention relates to methods for the nucleic acid amplification of multiple variants (strains) of any pathogen present in a sample, and preferably in a sample from a pathogen infected individual. In preferred embodiments, the pathogen is a retrovirus, such as HIV. The amplified pathogen nucleic acid can be used to identify the pathogen variants present in a sample, to quantitate the pathogen present in a sample, and as a nucleic acid vaccine, or in the preparation of antigen presenting cell vaccines. Nucleic acids produced by the methods of the invention or the proteins encoded thereby can be used to transfect/load antigen presenting cells. The loaded antigen presenting cells can then be used as a vaccine for the treatment of pathogen infection.; In another embodiment, nucleic acids produced by the methods of the invention can be used directly as nucleic acid vaccines without prior loading into antigen presenting cells.
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2.发明公开
公开(公告)号：EP2254998A1
公开(公告)日：2010-12-01
申请号：EP09713841.6
申请日：2009-02-27
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , A61K38/2026 , A61K48/00 , A61K48/005 , A61K2035/124 , C12N5/0639 , C12N2501/23 , C12N2501/24 , C12N2501/25 , C12N2510/00 , C12N2740/15043
摘要： A method is provided for treating or preventing an undesired immune response in a patient, comprising: administering to said patient, cells that transiently express, and/or that are transfected with mRNA encoding, one or more polypeptides selected from the group consisting of an IL-4 receptor agonist, an IFN-gamma receptor antagonist, an IFN-alpha receptor antagonist, an IL-12 receptor antagonist, an IL-23 receptor antagonist, and a TNF antagonist. Preferably, the cells selectively accumulate in one or more secondary lymphoid tissues at or proximate to the site of the undesired immune response. Related compositions are provided. The methods and compositions are useful for the treatment or prevention of undesired immune responses including, but not limited to, transplant rejection, autoimmune disease, allergy and immune responses directed against therapeutic compositions.
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公开(公告)号：EP2051987A2
公开(公告)日：2009-04-29
申请号：EP07811339.6
申请日：2007-08-16
发明人： NICOLETTE, Charles , BRAND, Stephen , ZHONG, Zhen , WANG, Hao , ARP, Jacqueline , RAMCHARRAN, Siobhan , BAROJA, Mirin Lorea
CPC分类号： A61K38/1774 , A61K9/0019 , A61K9/0053 , A61K31/341 , A61K31/365 , A61K31/4353 , A61K31/436 , A61K31/5377 , A61K35/12 , A61K35/761 , A61K38/13 , A61K38/1709 , A61K38/30 , A61K38/45 , A61K38/47 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/70503 , C07K16/289 , C12N2750/14143 , C12Y204/99 , C12Y302/02006 , A61K2300/00
摘要： The present invention relates to improved methods of suppressing and/or preventing an undesired immune response comprising the use of CD83. In some embodiments, CD83 is coadministered to a subject with at least one other immunosuppressive compound. Methods are also provided for generating tolerogenic dendritic cells and regulatory T cells. These cells can be used in vitro to produce additional cells for therapeutic purposes or they can be used in vivo to suppress and/or prevent an undesired immune response. Methods of the invention can be used to prevent or reduce the severity of autoimmune diseases and can also be used to induce tolerance to at least one therapeutic composition, such as a therapeutic protein or transplanted tissue.
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公开(公告)号：EP1794327A2
公开(公告)日：2007-06-13
申请号：EP05797971.8
申请日：2005-09-14
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/21 , A61K2039/5154 , A61K2039/5156 , C12N7/00 , C12N2740/16041 , C12N2740/16234 , C12N2740/16334 , C12Q1/703
摘要： This in invention relates to methods for the nucleic acid amplification of multiple variants (strains) of any pathogen present in a sample, and preferably in a sample from a pathogen infected individual. In preferred embodiments, the pathogen is a retrovirus, such as HIV. The amplified pathogen nucleic acid can be used to identify the pathogen variants present in a sample, to quantitate the pathogen present in a sample, and as a nucleic acid vaccine, or in the preparation of antigen presenting cell vaccines. Nucleic acids produced by the methods of the invention or the proteins encoded thereby can be used to transfect/load antigen presenting cells. The loaded antigen presenting cells can then be used as a vaccine for the treatment of pathogen infection.; In another embodiment, nucleic acids produced by the methods of the invention can be used directly as nucleic acid vaccines without prior loading into antigen presenting cells.
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公开(公告)号：EP3107996A1
公开(公告)日：2016-12-28
申请号：EP15751942.2
申请日：2015-02-20
IPC分类号： C12N5/10
CPC分类号： A61K39/0011 , A61K35/15 , A61K35/17 , A61K2039/5158 , C12N5/0638 , C12N5/0639 , C12N2501/52 , C12N2506/11 , G01N33/5005 , G01N33/5091 , G01N2800/52
摘要： The present invention relates to TSCM cells and uses thereof. TSCM cells can be used help identify and treat patients who are likely to experience particular treatment outcomes. In other embodiments TSCM cells are generated in vitro and used for adoptive transfer therapy.
摘要翻译： 本发明涉及TSCM细胞及其用途。 可以使用TSCM细胞来帮助识别和治疗可能经历特定治疗结果的患者。 在其他实施方案中，TSCM细胞在体外产生并用于过继转移治疗。
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6.发明授权
公开(公告)号：EP2254998B1
公开(公告)日：2015-12-23
申请号：EP09713841.6
申请日：2009-02-27
IPC分类号： C12N15/00
CPC分类号： C12N15/86 , A61K38/2026 , A61K48/00 , A61K48/005 , A61K2035/124 , C12N5/0639 , C12N2501/23 , C12N2501/24 , C12N2501/25 , C12N2510/00 , C12N2740/15043
摘要： A method is provided for treating or preventing an undesired immune response in a patient, comprising: administering to said patient, cells that transiently express, and/or that are transfected with mRNA encoding, one or more polypeptides selected from the group consisting of an IL-4 receptor agonist, an IFN-gamma receptor antagonist, an IFN-alpha receptor antagonist, an IL-12 receptor antagonist, an IL-23 receptor antagonist, and a TNF antagonist. Preferably, the cells selectively accumulate in one or more secondary lymphoid tissues at or proximate to the site of the undesired immune response. Related compositions are provided. The methods and compositions are useful for the treatment or prevention of undesired immune responses including, but not limited to, transplant rejection, autoimmune disease, allergy and immune responses directed against therapeutic compositions.
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公开(公告)号：EP2051987B1
公开(公告)日：2014-11-19
申请号：EP07811339.6
申请日：2007-08-16
发明人： NICOLETTE, Charles , BRAND, Stephen , ZHONG, Zhen , WANG, Hao , ARP, Jacqueline , RAMCHARRAN, Siobhan , BAROJA, Mirin Lorea
IPC分类号： A61K38/17 , A61K31/5377 , A61K31/436 , A61K45/06 , A61P37/06
CPC分类号： A61K38/1774 , A61K9/0019 , A61K9/0053 , A61K31/341 , A61K31/365 , A61K31/4353 , A61K31/436 , A61K31/5377 , A61K35/12 , A61K35/761 , A61K38/13 , A61K38/1709 , A61K38/30 , A61K38/45 , A61K38/47 , A61K39/3955 , A61K45/06 , A61K48/00 , C07K14/70503 , C07K16/289 , C12N2750/14143 , C12Y204/99 , C12Y302/02006 , A61K2300/00
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