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公开(公告)号：EP3144303A1
公开(公告)日：2017-03-22
申请号：EP16170994.4
申请日：2009-06-24
发明人： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd , KIM, Ganghyeok
IPC分类号： C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00 , C07D311/58
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： A compound which is 6-chloro-7-(4-(4-chloro-2-methoxyphenethylcarbamoyl)-phenoxy)chroman-4-carboxylic acid, or a pharmaceutically acceptable salt thereof. Said compound is either a racemic mixture or a single enantiomer, preferably Enantiomer 2 of 6-chloro-7-(4-(4-chloro-2-methoxyphenethylcarbamoyl)phenoxy)chroman-4-carboxylic acid, or a pharmaceutically acceptable salt thereof, in particular its sodium salt. Said compound for use in treating an immunologic disorder in a mammal.
摘要翻译： 6-氯-7-（4-（4-氯-2-甲氧基苯乙基氨基甲酰基） - 苯氧基）苯并二氢吡喃-4-羧酸或其药学上可接受的盐的化合物。 所述化合物是外消旋混合物或单一对映异构体，优选6-氯-7-（4-（4-氯-2-甲氧基苯乙基氨基甲酰基）苯氧基）苯并二氢吡喃-4-羧酸的对映异构体2或其药学上可接受的盐， 特别是其钠盐。 用于治疗哺乳动物免疫学障碍的所述化合物。
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公开(公告)号：EP2029581A1
公开(公告)日：2009-03-04
申请号：EP07754211.6
申请日：2007-03-27
发明人： MUNSON, Mark , HUNT, Kevin, W. , CLARK, Christopher, T. , KIM, Ganghyeok , BURGESS, Laurence, E. , RIZZI, James
IPC分类号： C07D403/12 , C07D401/12 , A61K31/416 , A61P29/00
CPC分类号： C07D403/12 , C07D401/12
摘要： Compounds of formula (I): in which A, B, X, Ar1, R8 and R4 have any of the meanings given in the specification, are inhibitors of p38 useful in the treatment and prevention of various disorders mediated by p38.
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公开(公告)号：EP3144303B1
公开(公告)日：2018-09-26
申请号：EP16170994.4
申请日：2009-06-24
发明人： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd , KIM, Ganghyeok
IPC分类号： C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00 , C07D311/58
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： Compounds of Formula (IV, VI): in which A1, A2, P2, P3, R7a, R7b, R8, R9, R10 and Z2 have the meanings given in the specification, are compounds useful for the preparation of DP2 receptor modulators useful in the treatment of immunologic diseases.
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公开(公告)号：EP2379535A1
公开(公告)日：2011-10-26
申请号：EP09793682.7
申请日：2009-12-18
申请人： Array Biopharma Inc.
发明人： COOK, Adam , HUNT, Kevin, W. , DELISLE, Robert Kirk , ROMOFF, Todd , CLARK, Christopher, T. , KIM, Ganghyeok , CORRETTE, Christopher, P. , DOHERTY, George, A. , BURGESS, Laurence, E.
IPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , A61K31/353 , A61P29/00
CPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： Compounds of Formula I: (I) in which A, A
1 , R
1 , R
7a , R
7b , R
8 and R
10 have the meanings given in the specification, are DP2 receptor inhibitors useful in the treatment of useful in the treatment and prevention of immunologic diseases, allergic diseases such as asthma, allergic rhinitis and atopic dermatitis, and other inflammatory diseases mediated by prostaglandin D
2 (PGD
2 ). The compounds of Formula I may also be useful in treating diseases or medical conditions involving the Th2 T cell via production of IL-4, IL-5 and/or IL-13.摘要翻译： 式I化合物：其中A，A 1，R 1，R 7a，R 7b，R 8和R 10具有说明书中给出的含义的式（I）化合物是DP2受体抑制剂，其可用于治疗用于治疗 预防免疫疾病，哮喘，过敏性鼻炎，特应性皮炎等过敏性疾病，前列腺素D 2（PGD 2）介导的其他炎症性疾病等。 式I化合物还可用于通过产生IL-4，IL-5和/或IL-13来治疗涉及Th2T细胞的疾病或医学病症。
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公开(公告)号：EP2307397A1
公开(公告)日：2011-04-13
申请号：EP09770959.6
申请日：2009-06-24
发明人： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd , KIM, Ganghyeok
IPC分类号： C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
摘要： Compounds of Formula (I): in which A
1 , A
2 , W, L, G, R
7a , R
7b , R
8 , R
9 and R
10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.摘要翻译： 式（I）化合物：其中A 1，A 2，W，L，G，R 7a，R 7b，R 8，R 9和R 10具有说明书中给出的含义的化合物是DP2受体调节剂， 治疗免疫性疾病。
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公开(公告)号：EP2379535B1
公开(公告)日：2016-06-15
申请号：EP09793682.7
申请日：2009-12-18
申请人： Array Biopharma Inc.
发明人： COOK, Adam , HUNT, Kevin, W. , DELISLE, Robert Kirk , ROMOFF, Todd , CLARK, Christopher, T. , KIM, Ganghyeok , CORRETTE, Christopher, P. , DOHERTY, George, A. , BURGESS, Laurence, E.
IPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , A61K31/353 , A61P29/00
CPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12
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公开(公告)号：EP2307397B1
公开(公告)日：2014-08-20
申请号：EP09770959.6
申请日：2009-06-24
发明人： BURGESS, Laurence, E. , CLARK, Christopher, T. , COOK, Adam , CORRETTE, Christopher, P. , DELISLE, Robert, Kirk , DOHERTY, George, A. , HUNT, Kevin, W. , ROMOFF, Todd , KIM, Ganghyeok
IPC分类号： C07D311/04 , C07D405/12 , C07D407/12 , A61K31/353 , A61P29/00
CPC分类号： C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12
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