公开(公告)号：EP3160517B1

公开(公告)日：2024-06-12

申请号：EP15742341.9

申请日：2015-06-24

IPC分类号： A61K49/00 ,  C07D311/04 ,  C07D239/72 ,  C07D249/04 ,  A61K47/22

CPC分类号： A61K49/0021 ,  C07D403/12 ,  C07D405/14 ,  C07D403/08 ,  C07D405/12 ,  C07D241/04 ,  A61K49/0052 ,  C12Q1/34 ,  C07D403/14 ,  C12Y301/01003 ,  C12Y305/01011

公开(公告)号：EP4209492A1

公开(公告)日：2023-07-12

申请号：EP21847386.6

申请日：2021-07-26

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Ruijin Hospital, Shanghai Jiaotong University School of Medicine ,  Suzhou Institute of Materia Medica China Science And Technology

发明人： LUO, Cheng ,  XI, Xiaodong ,  ZHOU, Bing ,  ZHU, Kongkai ,  MAO, Jianhua ,  LIU, Jingqiu ,  YANG, Yaxi ,  MEI, Lianghe ,  RUAN, Zheng ,  JIANG, Hao ,  XI, Wenda ,  LONG, Zhangbiao ,  XIAO, Bing ,  HUANG, Jiansong ,  JIANG, Hualiang

IPC分类号： C07D471/04 ,  C07D491/048 ,  C07D493/04 ,  C07D495/04 ,  C07D209/12 ,  C07D307/79 ,  C07D311/04 ,  C07D333/56 ,  A61K31/343 ,  A61K31/381 ,  A61K31/40 ,  A61K31/519 ,  A61P9/00

摘要： The present invention relates to a compound for treating thrombotic diseases. Specifically, the present invention provides a compound represented by formula I, or a pharmaceutically acceptable salt, or an enantiomer, or a diastereoisomer, or an atropisomer, or a racemate, or a polymorph, or a solvate, or an isotopically labeled derivative thereof. The compound disclosed in the present invention can be specifically combined with SH3 domain protein of Src kinase and then interfere the combination of integrin αIIbβ3 and Src kinase, so that outside-to-inside signal transduction is selectively inhibited and inside-to-outside signal transduction is not influenced; thus, while resisting thrombus, the compound of the present invention does not affect the normal physiological hemostatic function, prevents the occurrence of hemorrhagic side effect, and can be used as a new generation of effective medicine for preventing and treating thrombosis-related cardiovascular and cerebrovascular diseases.

公开(公告)号：EP3884936A1

公开(公告)日：2021-09-29

申请号：EP21171866.3

申请日：2019-02-11

申请人： MyMD Pharmaceuticals (Florida), Inc.

发明人： WILLIAMS, Jonnie R

IPC分类号： A61K31/352 ,  C07D311/04 ,  C07D311/80 ,  C12N15/09

摘要： A method of increasing the cannabinoid levels in a genetically modified Cannabis sativa plant includes genetically modifying the plant to induce the overexpression of the gene that controls the expression of tetrahydrocannabinolic acid (THCA) synthase and/or cannabidiolic acid (CBDA) synthase. The overexpression of THCA synthase and CBDA synthase catalyzes an increased synthesis of cannabigerolic acid to tetrahydrocannabinolic acid and cannabidiolic acid, as well as the cannabinoids (3aR)-2,4,4-trimethyl-7-pentyl-3,3a,4,9b-tetrahydrocyclopenta[c]chromen-9-ol and 2-((1R,5R)-3-methyl-5-(prop-1-en-2-yl)cyclopent-2-en-1-yl)-5-pentylbenzene-1,3-diol. Pharmaceutical compositions comprising the modified cannabinoids produced by the transgenic Cannabis sativa plant or prepared synthetically are used to treat various diseases and conditions.

公开(公告)号：EP3319952B8

公开(公告)日：2020-03-11

申请号：EP16741447.3

申请日：2016-07-01

申请人： Purisys LLC

发明人： DIALER, Lukas ,  PETROVIC, Denis ,  WEIGL, Ulrich

IPC分类号： C07D311/04 ,  C07D311/80

公开(公告)号：EP3164405A4

公开(公告)日：2018-05-23

申请号：EP15814834

申请日：2015-07-01

申请人： XAVIER UNIV OF LOUISIANA

发明人： WANG GUANGDI ,  ZHONG QIU ,  ZHENG SHILONG

IPC分类号： C07F5/02 ,  A61K31/69 ,  C07C233/07 ,  C07D311/04 ,  C07D403/12 ,  C07D417/12 ,  C07D501/20 ,  C07H23/00 ,  C07J31/00 ,  C07J51/00

CPC分类号： C07F5/025 ,  C07H23/00 ,  C07J31/006 ,  C07J51/00

摘要： Boron-based prodrugs of phenol- or aromatic hydroxyl group-containing therapeutic molecules (“original drugs”), uses thereof, and methods of making the same, are provided for achieving, for example, improved bioavailability, prolonged retention (e.g., in a circulatory system) and, in particular, significantly lowered therapeutically effective dosage in order to reduce adverse effects while maintaining the desired therapeutic effects of the original drugs.

公开(公告)号：EP3319952A1

公开(公告)日：2018-05-16

申请号：EP16741447.3

申请日：2016-07-01

申请人： Noramco, Inc.

发明人： DIALER, Lukas ,  PETROVIC, Denis ,  WEIGL, Ulrich

IPC分类号： C07D311/04 ,  C07D311/80

摘要： The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof.

公开(公告)号：EP3016714A1

公开(公告)日：2016-05-11

申请号：EP14735599.4

申请日：2014-07-07

申请人： LABORATOIRE BIODIM

发明人： LEDOUSSAL, Benoit ,  LE STRAT, Frédéric ,  CHASSET, Sophie ,  BARBION, Julien ,  BRIAS, Julie ,  CARAVANO, Audrey ,  FAIVRE, Fabien ,  VOMSCHEID, Sophie

IPC分类号： A61P31/18 ,  A61K31/353 ,  C07D311/04 ,  C07D405/10 ,  C07D491/052

CPC分类号： C07C59/13 ,  A61K31/192 ,  A61K31/352 ,  A61K31/381 ,  A61K31/4184 ,  A61K31/4709 ,  A61K31/4741 ,  A61K45/06 ,  C07C2601/02 ,  C07C2601/08 ,  C07D311/04 ,  C07D311/58 ,  C07D405/04 ,  C07D405/10 ,  C07D409/10 ,  C07D491/052

摘要： The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

摘要翻译： 本发明涉及化合物，它们在治疗或预防病毒疾病，包括HIV的用途。

公开(公告)号：EP2314580B1

公开(公告)日：2015-09-09

申请号：EP10004422.1

申请日：2010-04-27

申请人： The Health Concept GmbH

发明人： Steup, Christian ,  Herkenroth, Thomas

IPC分类号： C07D311/00 ,  C07D311/04 ,  C07D311/80 ,  C07C39/14

CPC分类号： C07D311/80 ,  C07B2200/07 ,  C07C37/50 ,  C07C2602/42 ,  C07D311/00 ,  C07D311/04 ,  Y02P20/55 ,  C07C39/19 ,  C07C39/23

公开(公告)号：EP2307397B1

公开(公告)日：2014-08-20

申请号：EP09770959.6

申请日：2009-06-24

申请人： Array Biopharma, Inc.

发明人： BURGESS, Laurence, E. ,  CLARK, Christopher, T. ,  COOK, Adam ,  CORRETTE, Christopher, P. ,  DELISLE, Robert, Kirk ,  DOHERTY, George, A. ,  HUNT, Kevin, W. ,  ROMOFF, Todd ,  KIM, Ganghyeok

IPC分类号： C07D311/04 ,  C07D405/12 ,  C07D407/12 ,  A61K31/353 ,  A61P29/00

CPC分类号： C07D311/58 ,  C07D311/04 ,  C07D405/12 ,  C07D407/12

公开(公告)号：EP2493571A1

公开(公告)日：2012-09-05

申请号：EP10774098.7

申请日：2010-10-28

申请人： Janssen Pharmaceutica, N.V.

发明人： PARKER, Michael, H. ,  HLASTA, Dennis, J. ,  HUANG, Yifang ,  REITZ, Allen, B. ,  LAWSON, Edward, C. ,  SCHUBERT, Carsten ,  STROBEL, Eric ,  TOUNGE, Brett ,  WHITE, Kimberly ,  WINTERS, Michael, P. ,  GHOSH, Shyamali

IPC分类号： A61P11/06 ,  A61K31/16 ,  C07C317/32 ,  C07D211/46 ,  C07D231/12 ,  C07C237/06 ,  C07C237/08 ,  C07D211/42 ,  C07D217/12 ,  C07D311/04 ,  C07D317/58 ,  C07D319/14 ,  C07D333/52 ,  C07D233/61 ,  C07D213/61 ,  C07D213/56 ,  C07D277/30

CPC分类号： C07C237/16 ,  C07C317/32 ,  C07D211/42 ,  C07D211/46 ,  C07D217/02 ,  C07D307/79 ,  C07D317/28 ,  C07D401/12 ,  C07D409/12

摘要： The present invention is directed to novel alkynyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by DPP-1.

摘要翻译： 本发明涉及新的炔基衍生物，含有它们的药物组合物以及它们在治疗由DPP-1调节的病症和病症中的用途。