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1.发明公开PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 有权吡啶-2-基氨基-I，2，4 -THIADIAZOLDERIVATE ALS葡糖激酶活化剂治疗糖尿病
公开(公告)号：EP2209778A1
公开(公告)日：2010-07-28
申请号：EP08834504.6
申请日：2008-09-15
发明人： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/433 , A61P3/10
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Provided are compounds of Formula (I): wherein R
2 , R
3 , R
13 , L and D
2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.-
2.发明公开
公开(公告)号：EP3878451A1
公开(公告)日：2021-09-15
申请号：EP21152373.3
申请日：2015-12-04
发明人： ALLEN, Shelley , BOYS, Mark Laurence , CHICARELLI, Mark J. , FELL, Jay Bradford , FISCHER, John P. , GAUDINO, John , HICKEN, Erik James , HINKLIN, Ronald Jay , KRASER, Christopher F. , LAIRD, Ellen , ROBINSON, John E. , TANG, Tony P. , BURGESS, Laurence E. , RIEGER, Robert Andrew , PHENEGER, Jed , SATOH, Yoshitaka , LEFTHERIS, Katerina , RAHEJA, Raj K. , BENNETT, Brydon L.
IPC分类号： A61K31/4985 , C07D487/04 , A61P29/00 , A61P37/00
摘要： Compounds of Formula I:
and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 and R 4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.-
公开(公告)号：EP3843850A1
公开(公告)日：2021-07-07
申请号：EP19766425.3
申请日：2019-08-29
申请人： Array BioPharma Inc.
发明人： HINKLIN, Ronald Jay , ALLEN, Shelley , BARBOUR, Patrick , COOK, Adam , DAHLKE, Joshua , GAUDINO, John , LAIRD, Ellen , MCNULTY, Oren T. , ZHAO, Qian
IPC分类号： A61P35/00 , C07D471/04 , A61K31/437
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公开(公告)号：EP1948652B1
公开(公告)日：2011-08-24
申请号：EP06826456.3
申请日：2006-10-24
发明人： AICHER, Thomas Daniel , LEE, Wai-Man , HINKLIN, Ronald Jay , CHICARELLI, Mark Joseph , BOYD, Steven Armen , CONDROSKI, Kevin Ronald
IPC分类号： C07D417/12 , C07D417/14 , A61K31/4439 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
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公开(公告)号：EP3867238A1
公开(公告)日：2021-08-25
申请号：EP19801996.0
申请日：2019-10-17
申请人： Array BioPharma Inc.
发明人： BLAKE, James F. , BOYS, Mark Laurence , CHICARELLI, Mark Joseph , COOK, Adam , ELSAYED, Mohamed S. A. , FELL, Jay B. , FISCHER, John P. , HINKLIN, Ronald Jay , MCNULTY, Oren T. , MEJIA, Macedonio J. , RODRIGUEZ, Martha E. , WONG, Christina E.
IPC分类号： C07D401/04 , C07D471/04 , C07D519/00 , A61P35/00 , A61K31/498 , A61K31/4985
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6.发明公开4,6-SUBSTITUTED-PYRAZOLO[1,5-a]PYRAZINES AS JANUS KINASE INHIBITORS 审中-公开作为JANUS激酶抑制剂的4,6-取代 - 吡唑并[1,5-a]吡嗪
公开(公告)号：EP3227297A1
公开(公告)日：2017-10-11
申请号：EP15819933.1
申请日：2015-12-04
发明人： ALLEN, Shelley , BOYS, Mark Laurence , CHICARELLI, Mark J. , FELL, Jay Bradford , FISCHER, John P. , GAUDINO, John , HICKEN, Erik James , HINKLIN, Ronald Jay , KRASER, Christopher F. , LAIRD, Ellen , ROBINSON, John E. , TANG, Tony P. , BURGESS, Laurence E. , RIEGER, Robert Andrew , PHENEGER, Jed , SATOH, Yoshitaka , LEFTHERIS, Katerina , RAHEJA, Raj K. , BENNETT, Brydon L.
IPC分类号： C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06
摘要： Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3 and R4 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of JAK kinase-associated diseases and disorders, such as autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
摘要翻译： 式I化合物及其立体异构体及其药学上可接受的盐和溶剂化物，其中R 1，R 2，R 3和R 4具有说明书中给出的含义，为一种或多种JAK激酶的抑制剂，并且可用于治疗 JAK激酶相关的疾病和病症，如自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液病和恶性肿瘤及其并发症。
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7.发明授权PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 有权吡啶-2-基氨基-I，2，4 -THIADIAZOLDERIVATE ALS葡糖激酶活化剂治疗糖尿病
公开(公告)号：EP2209778B1
公开(公告)日：2012-08-29
申请号：EP08834504.6
申请日：2008-09-15
发明人： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/433 , A61P3/10
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
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公开(公告)号：EP2571864A1
公开(公告)日：2013-03-27
申请号：EP11754769.5
申请日：2011-05-13
发明人： AICHER, Thomas Daniel , BENCSIK, Josef Roland , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , PRATT, Scott Alan , SINGH, Ajay , TURNER, Timothy M. , BOYD, Steven Armen
IPC分类号： C07D401/14 , A61K31/4545 , A61P3/10
CPC分类号： C07D413/14 , C07D401/14 , C07D405/14
摘要： Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which X
1 , X
2 , L, R
3 , R
4 , R
5 , R
6 , R
6a , R
7 , R
9 , R
9a , and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.摘要翻译： 式（I）化合物及其药学上可接受的盐，其中X 1，X 2，L，R 3，R 4，R 5，R 6，R 6a，R 7，R 9，R 9a和n具有 在说明书中给出的含义是GPR119的调节剂并且可用于治疗或预防疾病，例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关疾病 条件。
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公开(公告)号：EP1948652A1
公开(公告)日：2008-07-30
申请号：EP06826456.3
申请日：2006-10-24
发明人： AICHER, Thomas Daniel , LEE, Wai-Man , HINKLIN, Ronald Jay , CHICARELLI, Mark Joseph , BOYD, Steven Armen , CONDROSKI, Kevin Ronald
IPC分类号： C07D417/12 , C07D417/14 , A61K31/4439 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
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公开(公告)号：EP3947367A1
公开(公告)日：2022-02-09
申请号：EP20718387.2
申请日：2020-03-30
发明人： BLAKE, James F. , BOYS, Mark Laurence , CHICARELLI, Mark Joseph , COOK, Adam W. , ELSAYED, Mohamed S. A. , FELL, Jay Bradford , FISCHER, John P. , HINKLIN, Ronald Jay , JIANG, Yutong , MCNULTY, Oren T. , MEJIA, Macedonio J. , RODRIGUEZ, Martha E. , WONG, Christina E.
IPC分类号： C07D401/14 , C07D403/04 , C07D451/04 , C07D471/10 , C07D491/107 , C07D519/00 , A61K31/53 , A61P35/00 , C07D513/10
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