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1.发明公开PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 有权吡啶-2-基氨基-I，2，4 -THIADIAZOLDERIVATE ALS葡糖激酶活化剂治疗糖尿病
公开(公告)号：EP2209778A1
公开(公告)日：2010-07-28
申请号：EP08834504.6
申请日：2008-09-15
发明人： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/433 , A61P3/10
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Provided are compounds of Formula (I): wherein R
2 , R
3 , R
13 , L and D
2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.-
公开(公告)号：EP2820009B1
公开(公告)日：2018-01-31
申请号：EP13710222.4
申请日：2013-03-01
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP1948652A1
公开(公告)日：2008-07-30
申请号：EP06826456.3
申请日：2006-10-24
发明人： AICHER, Thomas Daniel , LEE, Wai-Man , HINKLIN, Ronald Jay , CHICARELLI, Mark Joseph , BOYD, Steven Armen , CONDROSKI, Kevin Ronald
IPC分类号： C07D417/12 , C07D417/14 , A61K31/4439 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
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公开(公告)号：EP2820009A1
公开(公告)日：2015-01-07
申请号：EP13710222.4
申请日：2013-03-01
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 提供式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐，其可用于治疗过度增殖性疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体，前药或药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。
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公开(公告)号：EP1948652B1
公开(公告)日：2011-08-24
申请号：EP06826456.3
申请日：2006-10-24
发明人： AICHER, Thomas Daniel , LEE, Wai-Man , HINKLIN, Ronald Jay , CHICARELLI, Mark Joseph , BOYD, Steven Armen , CONDROSKI, Kevin Ronald
IPC分类号： C07D417/12 , C07D417/14 , A61K31/4439 , A61P3/10
CPC分类号： C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04
摘要： Provided are compounds of Formula I wherein R1, R2, Y, Z and G are as defined herein, that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
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公开(公告)号：EP3867238A1
公开(公告)日：2021-08-25
申请号：EP19801996.0
申请日：2019-10-17
申请人： Array BioPharma Inc.
发明人： BLAKE, James F. , BOYS, Mark Laurence , CHICARELLI, Mark Joseph , COOK, Adam , ELSAYED, Mohamed S. A. , FELL, Jay B. , FISCHER, John P. , HINKLIN, Ronald Jay , MCNULTY, Oren T. , MEJIA, Macedonio J. , RODRIGUEZ, Martha E. , WONG, Christina E.
IPC分类号： C07D401/04 , C07D471/04 , C07D519/00 , A61P35/00 , A61K31/498 , A61K31/4985
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公开(公告)号：EP3321262A1
公开(公告)日：2018-05-16
申请号：EP17207123.5
申请日：2013-03-01
发明人： BLAKE, James F. , CHICARELLI, Mark Joseph , GARREY, Rustam Ferdinand , GAUDINO, John , GRINA, Jonas , MORENO, David A. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , CHEN, Huifen , ROBARGE, Kirk , ZHOU, Aihe
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D409/14 , C07D417/14 , C07D471/04 , C07F9/6558 , C07F9/6596 , A61K31/435 , A61K31/506 , A61P29/00 , A61P35/00
CPC分类号： C07D401/04 , A61K31/444 , A61K31/506 , A61K31/513 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07F9/65586
摘要： Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro , in situ , and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：EP2681215A1
公开(公告)日：2014-01-08
申请号：EP12709429.0
申请日：2012-02-28
发明人： BLAKE, James F. , CHEN, Huifen , CHICARELLI, Mark Joseph , DEMEESE, Jason , GARREY, Rustam , GAUDINO, John J. , KAUS, Robert J. , KOLAKOWSKI, Gabrielle R. , MARLOW, Allison L. , MOHR, Peter J. , REN, Li , SCHWARZ, Jacob , SIEDEM, Christopher S. , THOMAS, Allen A. , WALLACE, Eli , WENGLOWSKY, Steven Mark
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , A61K45/06 , C07D491/052
摘要： Compounds having the formula I wherein Z, Z1 Z2 Z, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
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9.发明授权PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 有权吡啶-2-基氨基-I，2，4 -THIADIAZOLDERIVATE ALS葡糖激酶活化剂治疗糖尿病
公开(公告)号：EP2209778B1
公开(公告)日：2012-08-29
申请号：EP08834504.6
申请日：2008-09-15
发明人： AICHER, Thomas Daniel , BOYD, Steven Armen , CHICARELLI, Mark Joseph , CONDROSKI, Kevin Ronald , FELL, Jay Bradford , FISCHER, John P. , GUNAWARDANA, Indrani W. , HINKLIN, Ronald Jay , SINGH, Ajay , TURNER, Timothy M. , WALLACE, Eli M.
IPC分类号： C07D417/12 , C07D417/14 , A61K31/433 , A61P3/10
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
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公开(公告)号：EP4216951A1
公开(公告)日：2023-08-02
申请号：EP21873279.0
申请日：2021-09-21
发明人： WANG, Xiaolun , MARX, Matthew Arnold , ALLEN, Shelley , CHICARELLI, Mark Joseph , DAHLKE, Joshua Ryan , DAI, Donghua , FELL, Jay Bradford , FISCHER John, Peter , HILTON, Michael Christopher , KAHN, Dean Russell , MEJIA, Macedonio Junior , NGUYEN, Phong , PAJK, Spencer , RODRIGUEZ, Martha E. , SAVECHENKOV, Pavel Yu , TANG, Tony Pisal
IPC分类号： A61K31/4353 , A61K31/519 , C07D471/04
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