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公开(公告)号:EP3523301A1
公开(公告)日:2019-08-14
申请号:EP17787843.6
申请日:2017-10-10
申请人: Array Biopharma Inc.
发明人: ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P. , REN, Li
IPC分类号: C07D471/04 , A61K31/437 , A61P35/00
摘要: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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公开(公告)号:EP3523301B1
公开(公告)日:2020-05-27
申请号:EP17787843.6
申请日:2017-10-10
申请人: Array Biopharma Inc.
发明人: ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P. , REN, Li
IPC分类号: C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号:EP3849986A1
公开(公告)日:2021-07-21
申请号:EP19773595.4
申请日:2019-09-06
发明人: BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KAHN, Dean , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , RAMANN, Ginelle A. , REN, Li , WALLS, Shane M. , ZHANG, Hailong
IPC分类号: C07D487/14 , C07D487/22 , C07D498/14 , C07D498/22 , A61P35/00 , A61K31/551
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公开(公告)号:EP3740486A1
公开(公告)日:2020-11-25
申请号:EP19703912.6
申请日:2019-01-18
发明人: WALLS, Shane M. , REN, Li , RAMANN, Ginelle A. , MORENO, David A. , METCALF, Andrew T. , MCFADDIN, Elizabeth A. , KOLAKOWSKI, Gabrielle R. , BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KAHN, Dean
IPC分类号: C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号:EP3694854A1
公开(公告)日:2020-08-19
申请号:EP18796243.6
申请日:2018-10-10
发明人: METCALF, Andrew T. , FRY, David , MCFADDIN, Elizabeth A. , KOLAKOWSKI, Gabrielle R. , HAAS, Julia , TANG, Tony P. , JIANG, Yutong
IPC分类号: C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号:EP3740491A1
公开(公告)日:2020-11-25
申请号:EP19703907.6
申请日:2019-01-18
发明人: BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , RAMANN, Ginelle A. , REN, Li
IPC分类号: C07D487/04 , A61P35/00 , A61K31/519
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