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1.发明授权Pyrimido cyclopentanes useful for the treatment of inflammatory or hyperproliferative diseases 有权用于治疗炎性或过度增殖性疾病合适Pyrimidocyclopentane
公开(公告)号：EP2170863B1
公开(公告)日：2015-09-02
申请号：EP08781337.4
申请日：2008-07-03
发明人： BENCSIK, Josef , BLAKE, James, F. , GRAHAM, James, M. , HENTEMANN, Martin, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SCHLACHTER, Stephen, T. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , WELCH, Mike , LIANG, Jun , SAFINA, Brian, S.
IPC分类号： C07D401/12 , C07D403/12
CPC分类号： C07D403/12 , C07D401/12
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2.发明授权
公开(公告)号：EP2173723B1
公开(公告)日：2011-08-31
申请号：EP08781340.8
申请日：2008-07-03
发明人： BENCSIK, Josef, R. , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , LIANG, Jun , SAFINA, Brian, S.
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：EP2173723A1
公开(公告)日：2010-04-14
申请号：EP08781340.8
申请日：2008-07-03
发明人： BENCSIK, Josef, R. , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , LIANG, Jun , SAFINA, Brian, S.
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译： 本发明提供式I的化合物，包括其互变异构体，拆分的对映异构体，非对映异构体，溶剂化物，代谢物，盐和药学上可接受的前药。 还提供了使用本发明化合物作为AKT蛋白激酶抑制剂并用于治疗过度增殖性疾病如癌症的方法。
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4.发明公开
公开(公告)号：EP2170863A2
公开(公告)日：2010-04-07
申请号：EP08781337.4
申请日：2008-07-03
发明人： BENCSIK, Josef , BLAKE, James, F. , GRAHAM, James, M. , HENTEMANN, Martin, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SCHLACHTER, Stephen, T. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , WELCH, Mike , LIANG, Jun , SAFINA, Brian, S.
IPC分类号： C07D401/12 , C07D403/12
CPC分类号： C07D403/12 , C07D401/12
摘要： The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：EP2173723B3
公开(公告)日：2014-11-19
申请号：EP08781340.8
申请日：2008-07-03
发明人： BENCSIK, Josef, R. , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , LIANG, Jun , SAFINA, Brian, S.
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70 , C07D401/12 , C07D403/12 , C07D409/12
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6.发明授权HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR 有权羟丙基吡咯烷基环丙烷酸AKT-PROTEINKINASEHEMMER
公开(公告)号：EP2240455B1
公开(公告)日：2012-12-26
申请号：EP09700629.0
申请日：2009-01-09
发明人： BENCSIK, Josef , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70
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7.发明公开HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR 有权羟基化pyrimidylaminoquinoline环戊烷AS AKT蛋白激酶抑制剂
公开(公告)号：EP2240455A1
公开(公告)日：2010-10-20
申请号：EP09700629.0
申请日：2009-01-09
发明人： BENCSIK, Josef , BLAKE, James, F. , KALLAN, Nicholas, C. , MITCHELL, Ian, S. , SPENCER, Keith, L. , XIAO, Dengming , XU, Rui , CHABOT, Christine , DO, Steven , LIANG, Jun , SAFINA, Brian , ZHANG, Birong
IPC分类号： C07D239/70 , A61K31/517 , A61P35/00
CPC分类号： C07D239/70
摘要： The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.
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公开(公告)号：EP1684694A2
公开(公告)日：2006-08-02
申请号：EP04811755.0
申请日：2004-11-19
发明人： MITCHELL, Ian, S. , SPENCER, Keith, L. , STENGEL, Peter , HAN, Yongxin , KALLAN, Nicholas, C. , MUNSON, Mark , VIGERS, Guy, P., A. , BLAKE, James , PISCOPIO, Anthony , JOSEY, John , MILLER, Scott , XIAO, Dengming , XU, Riu , RAO, Chang , WANG, Bin , BERNACKI, April, L.
IPC分类号： A61K6/00
CPC分类号： C07D239/94 , B41M3/008 , B44F1/10 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , G09F13/16 , Y10T428/24802 , Y10T428/24851 , Y10T428/25 , Y10T428/31507 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855
摘要： The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
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