专利检索 ap:("Arvinas Operations, Inc." OR "GENENTECH, INC.") AND inv:"BERLIN, Michael" 第 1 页

1.

发明公开
BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP4436966A1

公开(公告)日：2024-10-02

申请号：EP22843478.3

申请日：2022-11-23

申请人： Arvinas Operations, Inc. , GENENTECH, INC.

发明人： BERLIN, Michael , BROCCATELLI, Fabio , CHEN, Huifen , DRAGOVICH, Peter, Scott , WANG, Jing

IPC分类号： C07D413/14 , C07D417/14 , A61P35/00

CPC分类号： A61P35/00 , C07D417/14 , C07D413/14

2.

发明公开
BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP4038066A1

公开(公告)日：2022-08-10

申请号：EP20793893.7

申请日：2020-10-01

申请人： Arvinas Operations, Inc. , Genentech, Inc.

发明人： CREW, Andrew P. , WANG, Jing , BERLIN, Michael , DRAGOVICH, Peter , CHEN, Huifen , STABEN, Leanna

IPC分类号： C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D498/10 , C07D519/00 , A61P35/00 , A61K31/501 , A61K31/506 , A61K31/5386

3.

发明公开
BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP3774789A1

公开(公告)日：2021-02-17

申请号：EP19717685.2

申请日：2019-04-01

申请人： Arvinas Operations, Inc. , Genentech, Inc.

发明人： CREW, Andrew P. , WANG, Jing , BERLIN, Michael , DRAGOVICH, Peter , CHEN, Huifen , STABEN, Leanna

IPC分类号： C07D413/14 , C07D417/14 , A61K31/427 , A61P35/00

4.

发明公开
BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP4436965A1

公开(公告)日：2024-10-02

申请号：EP22839579.4

申请日：2022-11-23

申请人： Arvinas Operations, Inc. , GENENTECH, INC.

发明人： BERLIN, Michael , CHEN, Huifen , DRAGOVICH, Peter, Scott , STABEN, Leanna, Renee , WANG, Jing

IPC分类号： C07D413/14 , C07D417/14 , A61P35/00 , A61K31/427

CPC分类号： C07D417/14 , C07D413/14 , A61P35/00

5.

发明公开
CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME 审中-公开

公开(公告)号：EP3774772A1

公开(公告)日：2021-02-17

申请号：EP19719093.7

申请日：2019-04-09

申请人： Arvinas Operations, Inc.

发明人： CREW, Andrew P. , CREWS, Craig M. , DONG, Hanqing , HORNBERGER, Keith R. , WANG, Jing , QIAN, Yimin , ZIMMERMANN, Kurt , BERLIN, Michael , SNYDER, Lawrence B.

IPC分类号： C07D401/14 , C07D471/04 , C07D487/04 , C07D495/14 , A61P35/00 , A61K31/438 , A61K31/496 , A61K31/53 , A61K31/519

6.

发明公开
EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP3559002A1

公开(公告)日：2019-10-30

申请号：EP17884473.4

申请日：2017-12-22

申请人： Arvinas Operations, Inc. , Yale University

发明人： GREW, Andrew, P. , ZIMMERMANN, Kurt , WANG, Jing , BERLIN, Michael , DONG, Hanqing , ISHCHENKO, Alexey , QIAN, Yimin , CREWS, Craig, M. , JAIME-FIGUEROA, Saul , BURSLEM, George

IPC分类号： C07D487/04 , C07D417/04 , C07D403/14 , A61K31/519 , A61P35/00 , A61P29/00

7.

发明公开
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN 审中-公开

公开(公告)号：EP4232445A1

公开(公告)日：2023-08-30

申请号：EP21816573.6

申请日：2021-10-20

申请人： Arvinas Operations, Inc.

发明人： BERLIN, Michael , CREW, Andrew , DONG, Hanqing , HORNBERGER, Keith , SNYDER, Lawrence , WANG, Jing , ZIMMERMANN, Kurt

IPC分类号： C07D403/14 , A61P35/00

8.

发明公开
SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP4121167A1

公开(公告)日：2023-01-25

申请号：EP21718708.7

申请日：2021-03-19

申请人： Arvinas Operations, Inc.

发明人： SPARKS, Steven M. , ARAUJO, Erika , BERLIN, Michael , ZHANG, Wei , WANG, Jing

IPC分类号： A61P25/00 , A61K31/519 , A61P35/00 , A61P37/00 , C07D487/04 , C07D519/00

9.

发明公开
TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE 审中-公开

公开(公告)号：EP3999182A1

公开(公告)日：2022-05-25

申请号：EP20753840.6

申请日：2020-07-17

申请人： Arvinas Operations, Inc.

发明人： CREW, Andrew P. , BERLIN, Michael , DONG, Hanqing , ISHCHENKO, Alexey , CACACE, PH.D., Angela M. , CHANDLER, Julian T.

IPC分类号： A61P25/28 , C07D401/14 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04 , C07D519/00 , A61K31/437 , A61K31/519 , A61K31/4375

10.

发明公开
COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR 审中-公开

公开(公告)号：EP3660004A1

公开(公告)日：2020-06-03

申请号：EP20150564.1

申请日：2017-10-11

申请人： Arvinas Operations, Inc.

发明人： CREW, Andrew P. , HORNBERGER, Keith R. , SNYDER, Lawrence B. , ZIMMERMANN, Kurt , WANG, Jing , BERLIN, Michael , CREWS, Craig M. , DONG, Hanqing

IPC分类号： C07D233/86 , C07D401/04 , C07D491/107 , C07D471/10 , A61K31/4164 , A61K31/4439

摘要： The present disclosure relates to bifunctional compounds, which find utility to degrade and (inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.