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    HETERO COMPOUND
    2.
    发明公开
    HETERO COMPOUND 有权
    恶二唑化合物S1P1-Agonisten

    公开(公告)号：EP2003132A1

    公开(公告)日：2008-12-17

    申请号：EP07740850.8

    申请日：2007-04-02

    申请人： Astellas Pharma Inc.

    发明人： HARADA, Hironori ,  HATTORI, Kazuyuki ,  FUJITA, Kazuya ,  MORITA, Masataka ,  IMADA, Sunao ,  ABE, Yoshito ,  ITANI, Hiromichi ,  MOROKATA, Tatsuaki ,  TSUTSUMI, Hideo

    IPC分类号： C07D413/04 ,  A61K31/4245 ,  A61K31/4353 ,  A61K31/4709 ,  A61P37/02 ,  A61P37/06 ,  A61P43/00 ,  C07D417/04 ,  C07D471/04

    CPC分类号： C07D413/04 ,  C07D417/04 ,  C07D471/04

    摘要： [Problems]
    To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P 1 agonist activity.
    [Means for solving]
    Since the compound of the invention has an S1P 1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.

    摘要翻译： 提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1 激动剂活性。 [解决手段]由于本发明的化合物具有S1P 1激动剂活性，因此作为由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的有效成分是有用的，例如自身免疫疾病例如移植排斥 在移植器官，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺部 紊乱，哮喘，特应性皮炎，炎性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

    N-HYDROXYACRYLAMIDE COMPOUNDS
    3.
    发明公开
    N-HYDROXYACRYLAMIDE COMPOUNDS 有权
    N-羟基丙烯酰胺化合物

    公开(公告)号：EP1981877A1

    公开(公告)日：2008-10-22

    申请号：EP07708338.4

    申请日：2007-02-06

    申请人： Astellas Pharma Inc.

    发明人： SHIRAI, Fumiyuki ,  TSUTSUMI, Hideo ,  ITANI, Hiromichi ,  KOZUKI, Yoshihiro ,  EIKYU, Yoshiteru ,  MASUNAGA, Taro

    IPC分类号： C07D403/12 ,  C07D401/12 ,  A61K31/496 ,  A61P35/00

    CPC分类号： C07D409/14 ,  C07D401/12 ,  C07D403/12

    摘要： This invention relates to novel N-hydroxyacrylamide compounds of formula (I) and pharmaceutically acceptable salts thereof . More particularly, it relates to novel N-hydroxyacrylamide compounds and pharmaceutically acceptable salts thereof which act as a HDAC inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of HDAC- related disease.

    摘要翻译： 本发明涉及式（I）的新型N-羟基丙烯酰胺化合物及其药学上可接受的盐。 更具体地说，本发明涉及作为HDAC抑制剂的新型N-羟基丙烯酰胺化合物及其药学上可接受的盐，包含其的药物组合物，以及涉及治疗和/或预防HDAC-相关 疾病。