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    MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS
    2.
    发明公开
    MEDICAL USE OF CYCLIN DEPENDENT KINASES INHIBITORS 审中-公开
    激酶抑制剂细胞周期蛋白的医疗用途

    公开(公告)号：EP2046327A1

    公开(公告)日：2009-04-15

    申请号：EP07766316.9

    申请日：2007-07-20

    申请人： Astex Therapeutics Limited

    发明人： PIKE, Andrew ,  LYONS, John Francis

    IPC分类号： A61K31/415 ,  A61K31/44 ,  A61P13/12 ,  A61P29/00 ,  A61P25/00 ,  A61P9/10 ,  A61P9/12 ,  A61P3/10

    CPC分类号： A61K31/415 ,  A61K31/44

    摘要： The invention provides the use of a compound for the manufacture of a medicament for the treatment of pain, wherein the compound is a compound of the formula (0) : or a salt or tautomers or N-oxides or solvate thereof; wherein X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C=O, NR9(C=O) or O(C=O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy (e.g. methoxy); R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen (e.g. fluorine), hydroxyl or C1-4 alkoxy. The invention also provides the use of the compounds of the formula (0) for the treatment of stroke and for the treatment of polycystic kidney disease.