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公开(公告)号：EP3356350A1
公开(公告)日：2018-08-08
申请号：EP16777770.5
申请日：2016-09-29
发明人： CHESSARI, Gianni , HOWARD, Steven , BUCK, Ildiko Maria , CONS, Benjamin David , JOHNSON, Christopher Norbert , HOLVEY, Rhian Sara , REES, David Charles , ST. DENIS, Jeffrey David , TAMANINI, Emiliano , GOLDING, Bernard Thomas , HARDCASTLE, Ian Robert , CANO, Celine Florence , MILLER, Duncan Charles , CULLY, Sarah , NOBLE, Martin Edward Mäntylä , OSBORNE, James Daniel , PEACH, Joanne , LEWIS, Arwel , HIRST, Kim Louise , WHITTAKER, Benjamin Paul , WATSON, David Wyn , MITCHELL, Dale Robert , GRIFFIN, Roger John
IPC分类号： C07D403/12 , C07D405/14 , C07F9/572 , C07B59/00 , C07D403/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D209/48 , A61K31/4035 , A61P35/00
CPC分类号： C07D209/48 , C07B2200/05 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/06 , C07D413/12 , C07F9/5728
摘要： The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：EP3083616A1
公开(公告)日：2016-10-26
申请号：EP14815838.9
申请日：2014-12-19
发明人： CHESSARI, Gianni , JOHNSON, Christopher Norbert , HOWARD, Steven , DAY, James Edward Harvey , BUCK, Ildiko Maria , GRIFFITHS-JONES, Charlotte Mary , SAXTY, Gordon , TAMANINI, Emiliano , WILSHER, Nicola Elisabeth
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K31/5377
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
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公开(公告)号：EP2909198A1
公开(公告)日：2015-08-26
申请号：EP13780389.6
申请日：2013-10-18
发明人： CHESSARI, Gianni , JOHNSON, Christopher Norbert , PAGE, Lee William , BUCK, Ildiko Maria , DAY, James Edward Harvey , HOWARD, Steven , SAXTY, Gordon , MURRAY, Christopher William
IPC分类号： C07D403/14 , C07D471/04 , C07D519/00 , A61K31/437 , A61P35/00
CPC分类号： C07D403/14 , C07D471/04 , C07D519/00
摘要： The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的新的双环杂环化合物：涉及包含所述化合物的药物组合物以及涉及所述化合物在治疗疾病中的用途， 癌症。
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公开(公告)号：EP2699562A1
公开(公告)日：2014-02-26
申请号：EP12717460.5
申请日：2012-04-20
发明人： WOOLFORD, Alison Jo-Anne , HOWARD, Steven , BUCK, Ildiko Maria , CHESSARI, Gianni , JOHNSON, Christopher Norbert , TAMANINI, Emiliano , DAY, James Edward Harvey , CHIARPARIN, Elisabetta , HEIGHTMAN, Thomas Daniel , FREDERICKSON, Martyn , GRIFFITHS-JONES, Charlotte Mary
IPC分类号： C07D401/06 , C07D471/04 , C07D471/10
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2a，R2b，R3a，R3b，R5，R6，R7，R8，R9，p和E如本文所定义; 包括所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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公开(公告)号：EP3868747A1
公开(公告)日：2021-08-25
申请号：EP20214100.8
申请日：2012-04-20
发明人： WOOLFORD, Alison Jo-Anne , HOWARD, Steven , BUCK, Ildiko Maria , CHESSARI, Gianni , JOHNSON, Christopher Norbert , TAMANINI, Emiliano , DAY, James Edward Harvey , CHIARPARIN, Elisabetta , HEIGHTMAN, Thomas Daniel , FREDERICKSON, Martyn , GRIFFITHS-JONES, Charlotte Mary
IPC分类号： C07D401/06 , C07D471/04 , C07D471/10
摘要： The invention relates to bicyclic heterocycle compounds of formula (I):
or tautomeric or stereochemically isomeric forms, N -oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R 1 , R 2a , R 2b , R 3a , R 3b , R 5 , R 6 , R 7 , R 8 , R 9 , p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.-
公开(公告)号：EP2699574B1
公开(公告)日：2019-06-19
申请号：EP12717459.7
申请日：2012-04-20
发明人： BUCK, Ildiko Maria , CHESSARI, Gianni , HOWARD, Steven , REES, David Charles , WOOLFORD, Alison Jo-Anne
IPC分类号： C07D471/04 , C07D498/04 , A61K31/437 , A61K31/5383 , A61K31/4985 , A61K31/519 , A61P35/00
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公开(公告)号：EP2699574A1
公开(公告)日：2014-02-26
申请号：EP12717459.7
申请日：2012-04-20
发明人： BUCK, Ildiko Maria , CHESSARI, Gianni , HOWARD, Steven , REES, David Charles , WOOLFORD, Alison Jo-Anne
IPC分类号： C07D471/04 , C07D498/04 , A61K31/437 , A61K31/5383 , A61K31/4985 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/5383 , A61K31/5386 , A61K45/06 , C07D498/04 , C07D498/10 , A61K2300/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2, R3, A, W, U and V are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译： 本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2，R3，A，W，U和V如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途，例如， 癌症。
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公开(公告)号：EP3356344A1
公开(公告)日：2018-08-08
申请号：EP16777769.7
申请日：2016-09-29
发明人： CHESSARI, Gianni , HOWARD, Steven , BUCK, Ildiko Maria , CONS, Benjamin David , JOHNSON, Christopher Norbert , HOLVEY, Rhian Sara , REES, David Charles , ST. DENIS, Jeffrey David , TAMANINI, Emiliano , GOLDING, Bernard Thomas , HARDCASTLE, Ian Robert , CANO, Celine Florence , MILLER, Duncan Charles , NOBLE, Martin Edward Mäntylä , OSBORNE, James Daniel , PEACH, Joanne , LEWIS, Arwel , HIRST, Kim Louise , WHITTAKER, Benjamin Paul , WATSON, David Wyn , MITCHELL, Dale Robert
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07B59/00 , C07D401/06 , C07D403/06 , C07D403/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D487/08 , A61K35/00 , A61K31/454 , A61K31/506
CPC分类号： C07D401/06 , C07B59/002 , C07B2200/05 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/08
摘要： The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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