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1.发明公开
公开(公告)号：EP4151633A1
公开(公告)日：2023-03-22
申请号：EP22200147.1
申请日：2016-09-29
发明人： Chessari, Gianni , Howard, Steven , Buck, Ildiko Maria , Cons, Benjamin David , Johnson, Christopher Norbert , Holvey, Rhian Sara , St. Denis, Jeffrey David , Tamanini, Emiliano , Golding, Bernard Thomas , Hardcastle, Ian Robert , Cano, Celine Florence , Miller, Duncan Charles , Cully, Sarah , Noble, Martin Edward Mäntylä , Osborne, James Daniel , Peach, Joanne , Lewis, Arwell , Hirst, Kim Louise , Whittaker, Benjamin Paul , Mitchell, Dale Robert , Griffin, Roger John , Rees, David Charles , Watson, David Wyn
IPC分类号： C07D403/12 , C07D405/14 , C07F9/572 , C07B59/00 , C07D403/06 , C07D405/12 , C07D413/06 , C07D413/12 , C07D209/48 , A61K31/4035 , A61P35/00
摘要： The invention provides a compound of formula (I):
or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
2.发明公开
公开(公告)号：EP2332909A1
公开(公告)日：2011-06-15
申请号：EP11158930.5
申请日：2006-04-13
发明人： Chessari, Gianni , Congreve, Miles Stuart , Navarro, Eva Figueroa , Frederickson, Martyn , Murray, Christopher , Woolford, Alison Jo-Ann , Carr, Maria Grazia , Downham, Robert , O'Brien, Michael Alistair , Phillips, Theresa Rachel , Woodhead, Andrew James
IPC分类号： C07D209/44 , C07D209/08 , C07D215/08 , C07D491/10 , C07D471/04 , C07D471/10 , C07D491/08 , C07D401/04 , C07D401/12 , A61K31/438 , A61K31/439 , A61K31/403
CPC分类号： C07D401/12 , C07C65/21 , C07D209/08 , C07D209/44 , C07D215/08 , C07D217/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/08 , C07D491/10
摘要： The invention provides compounds of the formula (I):
or salts, tautomers, solvates and N-oxides thereof; wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy; methoxy or hydrogen; provided that at least one of R 1 and R 2 is hydroxy; R 3 is selected from hydrogen; halogen; cyano; optionally substituted C 1-5 hydrocarbyl and optionally substituted C 1-5 hydrocarbyloxy; R 4 is selected from hydrogen; a group -(O) n -R 7 where n is 0 or 1 and R 7 is an optionally substituted acyclic C 1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C 1-5 hydrocarbylamino; or R 3 and R 4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR 5 R 6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur.
The compounds have activity as Hsp90 inhibitors.摘要翻译： 本发明提供了式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R1是羟基或氢; R2是羟基; 甲氧基或氢; 条件是R1和R2中的至少一个是羟基; R3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5烃氧基; R4选自氢; 基团 - （O）n -R 7，其中n是0或1并且R 7是任选取代的无环C 1-5烃基或具有3至7个环成员的单环碳环或杂环基团; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C1-5烃基氨基; 或R3和R4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成任选取代的具有8至12个环成员的双环杂环基团，其中至多5个环成员为选自氧，氮和硫的杂原子。 这些化合物具有Hsp90抑制剂的活性。
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3.发明授权HYDROXYBENZAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF HSP90 有权HYDROXYBENZAMIDDERIVATE及其作为HSP90抑制剂
公开(公告)号：EP2332909B1
公开(公告)日：2014-10-15
申请号：EP11158930.5
申请日：2006-04-13
发明人： Chessari, Gianni , Congreve, Miles Stuart , Navarro, Eva Figueroa , Frederickson, Martyn , Murray, Christopher , Woolford, Alison Jo-Ann , Carr, Maria Grazia , Downham, Robert , O'Brien, Michael Alistair , Phillips, Theresa Rachel , Woodhead, Andrew James
IPC分类号： C07D209/44 , C07D209/08 , C07D215/08 , C07D491/10 , C07D471/04 , C07D471/10 , C07D491/08 , C07D401/04 , C07D401/12 , A61K31/438 , A61K31/439 , A61K31/403
CPC分类号： C07D401/12 , C07C65/21 , C07D209/08 , C07D209/44 , C07D215/08 , C07D217/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/10 , C07D491/08 , C07D491/10
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