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公开(公告)号：EP2493870A1
公开(公告)日：2012-09-05
申请号：EP10769052.1
申请日：2010-10-25
申请人： AstraZeneca AB
发明人： BARLAAM, Bernard, Christophe , DEGORCE, Sebastien, Louis , LAMBERT-VAN DER BREMPT, Christine, Marie, Paul , MORGENTIN, Remy, Robert , PLE, Patrick
IPC分类号： C07D311/22 , A61K31/5377 , A61K31/558
CPC分类号： C07D311/74 , A61K31/277 , A61K31/337 , A61K31/5377 , A61K45/06 , C07D311/22 , C07D405/06 , C07D413/06
摘要： The invention concerns chromenone derivatives of Formula (I) or a pharmaceutically-acceptable salts thereof, wherein each of R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , n and R
9 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.-
2.发明公开4-ANILINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS 审中-公开4-ANILINOSUBSTITUIERTE CHINAZOLINDERIVATE ALS TYROSINKINASEINHIBITOREN
公开(公告)号：EP1957499A1
公开(公告)日：2008-08-20
申请号：EP06808705.5
申请日：2006-11-29
申请人： AstraZeneca AB
IPC分类号： C07D498/06 , C07D405/12 , C07D239/94 , A61K31/495 , A61P35/00
CPC分类号： C07D239/94 , C07D405/12
摘要： A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
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公开(公告)号：EP3440079A1
公开(公告)日：2019-02-13
申请号：EP17714741.0
申请日：2017-03-30
申请人： Astrazeneca AB
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP2303861B1
公开(公告)日：2014-04-23
申请号：EP09766150.8
申请日：2009-06-15
申请人： AstraZeneca AB
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14
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5.发明授权4- (IH-INDAZOL-5-YL-AMINO)-QUINAZOLINE COMPOUNDS AS ERBB RECEPTOR TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER 有权4-（1H-吲唑-5-基氨基）喹唑啉化合物作为癌症治疗中的ErbB受体的抑制剂
公开(公告)号：EP1928861B1
公开(公告)日：2010-11-17
申请号：EP06779419.8
申请日：2006-09-14
申请人： AstraZeneca AB
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/517 , A61P35/00
CPC分类号： C07D403/12 , C07D401/14 , C07D417/14
摘要： A quinazoline derivative of the Formula I: wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm blooded animal such as man.
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公开(公告)号：EP3947376A1
公开(公告)日：2022-02-09
申请号：EP20715055.8
申请日：2020-03-27
申请人： Astrazeneca AB
发明人： YANG, Bin , HAYHOW, Thomas, George, Christopher , FALLAN, Charlene , SCOTT, James, Stewart , DIENE, Coura , BARLAAM, Bernard, Christophe , NISSINK, Johannes, Wilhelmus, Maria
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437 , A61K31/506
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公开(公告)号：EP3596076A1
公开(公告)日：2020-01-22
申请号：EP18713818.5
申请日：2018-03-15
申请人： Astrazeneca AB
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
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公开(公告)号：EP3433251A1
公开(公告)日：2019-01-30
申请号：EP17712123.3
申请日：2017-03-20
申请人： Astrazeneca AB
IPC分类号： C07D405/14 , A61K31/502 , A61P35/00
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9.发明授权PYRIDINE AND PYRAZINE DERIVATIVES USEFUL IN THE TREATMENT OF CELL PROLIFERATIVE DISORDERS 有权用于治疗细胞增殖性疾病SUITABLE吡啶和吡嗪
公开(公告)号：EP2215085B1
公开(公告)日：2011-09-07
申请号：EP08841876.9
申请日：2008-10-22
申请人： AstraZeneca AB
发明人： BARLAAM, Bernard, Christophe , BOWER, Justin, Fairfield , DELOUVRIE, Benedicte , FAIRLEY, Gary , HARRIS, Craig, Steven , LAMBERT, Christine , OUVRY, Gilles , WINTER, Jon, James, Gordon
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , A61K31/497 , A61K31/4427 , A61P35/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The invention concerns pyridine a nd pyrazine derivatives of Formula (I) or a pharmaceutically-acceptable salt thereof, wherein each of W, G1, G 2, G3, G4, J, Ring A, n and R 3 has any of the meanings defined hereinbefo re in the description; processes for their preparation, pharmaceutical compositions containi ng them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
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10.发明公开N' - (PHENYL) -N- (MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINE DERIVATIVES AS EPHB4 KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE CONDITIONS 审中-公开NY-（苯基）-N-（吗啉-4-基 - 吡啶-2-基）嘧啶-2,4-二胺衍生物作为用于增殖LEIDEN治疗EphB4激酶的抑制剂
公开(公告)号：EP2150545A1
公开(公告)日：2010-02-10
申请号：EP08737220.7
申请日：2008-04-25
申请人： AstraZeneca AB
IPC分类号： C07D401/12 , C07D403/12 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C07D239/50
摘要： The invention concerns pyrimidine com pounds of Formula (I), or a pharmaceutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to pr ocesses for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to th e inhibition of EphB4 kinases.
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