公开(公告)号：EP1263714B1

公开(公告)日：2004-04-28

申请号：EP01906490.6

申请日：2001-02-20

申请人： AstraZeneca AB

发明人： BIRKINSHAW, Tim ,  CHESHIRE, David ,  METE, Antonio

IPC分类号： C07C255/50 ,  C07C323/31 ,  C07C317/32 ,  C07C217/54 ,  C07C211/49 ,  C07D295/04 ,  A61K31/00 ,  A61P29/00

CPC分类号： C07D233/64 ,  C07C217/48 ,  C07C255/54 ,  C07D213/38 ,  C07D277/32 ,  C07D295/088 ,  C07D333/32

摘要： There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

公开(公告)号：EP1263714A1

公开(公告)日：2002-12-11

申请号：EP01906490.6

申请日：2001-02-20

申请人： AstraZeneca AB

发明人： BIRKINSHAW, Tim ,  CHESHIRE, David ,  METE, Antonio

IPC分类号： C07C255/50 ,  C07C323/31 ,  C07C317/32 ,  C07C217/54 ,  C07C211/49 ,  C07D295/04 ,  A61K31/00 ,  A61P29/00

CPC分类号： C07D233/64 ,  C07C217/48 ,  C07C255/54 ,  C07D213/38 ,  C07D277/32 ,  C07D295/088 ,  C07D333/32

摘要： There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.

摘要翻译： 提供了式（I）的新化合物，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，及其药学上可接受的盐，以及其对映体和外消旋体; 以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别适用于治疗或预防炎性疾病和疼痛。