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公开(公告)号：EP2121137B1
公开(公告)日：2012-04-25
申请号：EP07848557.0
申请日：2007-12-17
申请人： AstraZeneca AB
发明人： FORD, Rhonan , METE, Antonio , MILLICHIP, Ian , TEOBALD, Barry
IPC分类号： C07D453/02
CPC分类号： C07D453/02 , C07D519/00
摘要： The invention provides compounds of formula (I) wherein R5 is a group of formula (II) or (III) and R1, R2, R3, R4, R6, a, b, Z, Y and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation.
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公开(公告)号：EP1539731B1
公开(公告)日：2008-01-02
申请号：EP03738863.4
申请日：2003-07-15
申请人： AstraZeneca AB
发明人： METE, Antonio , WALTERS, Iain
IPC分类号： C07D333/34 , A61K31/381 , A61P29/00
CPC分类号： C07D333/38
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, M, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译： 提供了新的式（I）化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，M，T，U，Y，V和W如说明书中所定义。 以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别适用于治疗或预防炎性疾病和疼痛。
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3.发明授权HETEROARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE 有权HETEROARYLHETEROALKYLAMIN衍生物及其氧化氮合酶抑制剂
公开(公告)号：EP1414802B1
公开(公告)日：2006-04-26
申请号：EP02749497.0
申请日：2002-07-26
申请人： AstraZeneca AB
IPC分类号： C07D213/85 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4427 , A61P29/00 , A61P25/00
CPC分类号： C07D409/12 , A61K31/44 , A61K31/4427 , C07D213/85 , C07D413/12 , C07D417/12
摘要： There are provided novel compounds of formula (I). wherein R?1, R2, R3¿, Q, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
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公开(公告)号：EP1539732A1
公开(公告)日：2005-06-15
申请号：EP03765417.5
申请日：2003-07-15
申请人： AstraZeneca AB
发明人： METE, Antonio , WALTERS, Iain
IPC分类号： C07D333/34 , A61K31/381 , A61P29/00
CPC分类号： C07D333/34
摘要： There are provided novel compounds of formula (I) wherein R1, R2, R3, R10, M, Q, T, U, Y, V and W are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译： 提供了式（I）的新化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 10，M，Q，T，U，Y，V和W如说明书中所定义。 以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。 这些化合物是一氧化氮合酶的抑制剂，因此特别适用于治疗或预防炎性疾病和疼痛。
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公开(公告)号：EP2427445A1
公开(公告)日：2012-03-14
申请号：EP10719056.3
申请日：2010-05-05
申请人： AstraZeneca AB
发明人： FORD, Rhonan , METE, Antonio , MATHER, Andrew , MILLICHIP, Ian
IPC分类号： C07D309/14 , A61K31/351 , A61P11/00
CPC分类号： C07D309/14
摘要： The present invention provides compounds of formula (I), in which y, m, n, R
1 , R
2 and Q are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use in therapy.摘要翻译： 本发明提供了式（I）化合物，其中y，m，n，R 1，R 2和Q如说明书中所定义，其制备方法，含有它们的药物组合物以及它们在治疗中的用途。
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6.发明授权NOVEL N-(FLUORO-PYRAZINYL)-PHENYLSULFONAMID.ES AS MOODULATORS OF CHEMOKINE RECEPTOR CCR4. 有权NEW N-（FLUORPYRAZINYL）phenylsulfonamides AS趋化因子受体CCR4的调节剂
公开(公告)号：EP1968951B1
公开(公告)日：2011-06-22
申请号：EP06835834.0
申请日：2006-12-11
申请人： AstraZeneca AB
IPC分类号： C07D241/22 , A61K31/4965 , A61P11/00 , A61P11/06
CPC分类号： C07D241/22
摘要： The invention provides N-(fluoro-pyrazinyl)-phenylsulfonamides of formula (I) wherein R1 -R5 are as defined in the specification; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
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7.发明公开PHARMACEUTICAL PRODUCT COMPRISING A MUSCARINIC RECEPTOR ANTAGONIST AND A beta2-ADRENOCEPTOR AGONIST 审中-公开药物产品包含毒蕈碱性受体拮抗剂和β2 BLOCKING激动剂
公开(公告)号：EP2315589A1
公开(公告)日：2011-05-04
申请号：EP09746868.0
申请日：2009-05-12
发明人： BULL, Richard , FORD, Rhonan , MATHER, Andrew , METE, Antonio , WILEY, Katherine
IPC分类号： A61K31/439 , A61P11/06 , A61P11/08 , A61K31/428
CPC分类号： A61K45/06 , A61K31/428 , A61K31/439 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is a &bgr;2-adrenoceptor agonist, or use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma.
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8.发明授权QUINICLIDINE DERIVATIVES OF (HETERO) ARYLCYCLOHEPTANECARBOXYLIC ACID AS MUSCARINIC RECEPTOR ANTAGONISTS 有权OF（杂）ARYLCYCLOHEPTANCARBONSÄURENCHINICLIDINDERIVATE作为反对者AM毒蕈碱
公开(公告)号：EP2094694B1
公开(公告)日：2011-01-26
申请号：EP07824574.3
申请日：2007-11-13
申请人： AstraZeneca AB
发明人： FORD, Rhonan , MATHER, Andrew , METE, Antonio
IPC分类号： C07D453/02 , A61K31/439
CPC分类号： C07D453/02
摘要： The invention provides compounds of formula (I) wherein R4 is a group of formula (II) or (IIIa) or (IIIb) and R1, R2, R3, R5, a, b and X are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing pharmaceutical compositions, their use in therapy and intermediates of use in their preparation (I), (II), (IIIa), (IIIb).
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9.发明公开NOVEL N-(FLUORO-PYRAZINYL)-PHENYLSULFONAMID.ES AS MOODULATORS OF CHEMOKINE RECEPTOR CCR4. 有权新颖的N-（氟 - 吡嗪基） - 苯基磺酰胺作为趋化因子受体CCR4的调节剂。
公开(公告)号：EP1968951A1
公开(公告)日：2008-09-17
申请号：EP06835834.0
申请日：2006-12-11
申请人： AstraZeneca AB
IPC分类号： C07D241/22 , A61K31/4965 , A61P11/00 , A61P11/06
CPC分类号： C07D241/22
摘要： The invention provides N-(fluoro-pyrazinyl)-phenylsulfonamides of formula (I) wherein R1 -R5 are as defined in the specification; processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy
摘要翻译： 本发明提供式（I）的N-（氟 - 吡嗪基） - 苯基磺酰胺，其中R 1 -R 5如说明书中所定义; 在其制备中使用的方法和中间体，含有它们的药物组合物以及它们在治疗中的用途
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10.发明公开
公开(公告)号：EP2300464A1
公开(公告)日：2011-03-30
申请号：EP08750581.4
申请日：2008-05-13
发明人： FORD, Rhonan, Lee , MATHER, Andrew, Nigel , METE, Antonio , BULL, Richard, James , SKIDMORE, Elizabeth, Anne
IPC分类号： C07D453/02 , A61K31/439 , A61P11/00
CPC分类号： C07D453/02
摘要： The invention provides named compounds of formula (I), pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions and their use in therapy.
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