公开(公告)号：EP1084059A1

公开(公告)日：2001-03-21

申请号：EP99925530.0

申请日：1999-04-21

申请人： AstraZeneca AB

发明人： BRENNAN, John,Design By Design Co. ,  MATTHEWS, Roger,Horton Matthews Product ,  METCALF, Stephen

IPC分类号： B65B39/00 ,  B65B31/10

CPC分类号： B65B31/003

摘要： A filling apparatus for, a filling system for and a method of introducing into a container a suspension or solution of a substance, in particular a pharmaceutical substance, in a propellant under pressure, the filling apparatus comprising: a main body (4) including a passageway (20) for communicating, in use, with a valve stem (144) extending from a head (141) of a body (139) of a container (138); a fill actuator (7) comprising a filling valve assembly (29) in communication with the passageway (20) for selectively introducing thereinto propellant under pressure containing a substance in a suspension or solution; an exhaust actuator (10) comprising an exhaust valve assembly (48) in communication with the passageway (20) for selectively exhausting therefrom propellant under pressure containing substance; and a container-engaging body (16) in communication with the passageway (20) for receiving, in use, the head (141) of the body (139) of the container (138), the container-engaging body (16) including a chamber (116) of greater radial dimension than the valve stem (144) of the container (138) into which, in use, extends the valve stem (144) of the container (138) and a conduit (126) in communication with the chamber (116) for feeding a pressurised fluid thereto.

公开(公告)号：EP1073587A1

公开(公告)日：2001-02-07

申请号：EP99925528.4

申请日：1999-04-21

申请人： AstraZeneca AB

发明人： BRENNAN, John,Design By Design Co. ,  FLETCHER, Ian ,  METCALF, Stephen ,  PANCHOLI, Yogesh ,  SMITH, David,Flow Science Ltd.

IPC分类号： B65B39/00 ,  B65B31/10

CPC分类号： B65B31/003

摘要： A filling apparatus for, a filling system for and a method of introducing into a container a suspension or solution of a substance, in particular a pharmaceutical substance, in a propellant under pressure, the filling apparatus comprising: a main body (4) including a passageway (20) having an inlet opening (21) and first and second outlet openings (25, 22), the first outlet opening (25) communicating, in use, with a valve stem (144) extending from a head (141) of a body (139) of a container (138); a fill actuator (7) in communication with the inlet opening (21) of the passageway (20) comprising a filling valve assembly (29) for selectively introducing propellant under pressure containing a substance in a suspension or solution into the passageway (20); an exhaust actuator (10) in communication with the second outlet opening (22) of the passageway (20) comprising an exhaust valve assembly (48) for selectively exhausting propellant under pressure containing substance from the passageway (20) and including at least one exhaust gas conduit (84, 92, 93) having an outlet (86, 94, 95) configured so as, in use, to provide a flow of exhaust gas substantially aligned with a flow of propellant containing substance from the second outlet opening (22) of the passageway (20); and a container-engaging body (16) for receiving, in use, the head (141) of the body (139) of the container (138) which includes the valve stem (144).

摘要翻译： 1。一种用于在压力下的推进剂中将物质尤其是药物物质的悬浮液或溶液引入容器的填充系统和用于将其填充到容器中的方法的填充设备，所述填充设备包括：主体（4），其包括 具有入口开口（21）以及第一和第二出口开口（25,22）的第一出口开口（25），所述第一出口开口（25）在使用中与从所述入口开口的头部（141）延伸的阀杆（144） 容器（138）的主体（139）; 与通道（20）的入口开口（21）连通的填充致动器（7），其包括填充阀组件（29），用于选择性地将含有悬浮液或溶液中的物质的推进剂引入到通道（20）中; 与通道（20）的第二出口开口（22）连通的排气致动器（10），该排气致动器包括排气阀组件（48），用于在来自通道（20）的含压物质的压力下选择性地排出推进剂并且包括至少一个排气 具有出口（86,94,95）的气体导管（84,92,93），其构造成在使用中提供与来自第二出口开口（22）的含推进剂物质流大致对齐的废气流， （20）的通道; 和容器接合体（16），用于在使用中接收容器（138）的包括阀杆（144）的主体（139）的头部（141）。