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公开(公告)号：EP1084059B1
公开(公告)日：2004-03-24
申请号：EP99925530.0
申请日：1999-04-21
申请人： AstraZeneca AB
发明人： BRENNAN, John, Design By Design Co. , MATTHEWS, Roger, Horton Matthews Product , METCALF, Stephen
CPC分类号： B65B31/003
摘要： A filling apparatus for, a filling system for and a method of introducing into a container a suspension or solution of a substance, in particular a pharmaceutical substance, in a propellant under pressure, the filling apparatus comprising: a main body (4) including a passageway (20) for communicating, in use, with a valve stem (144) extending from a head (141) of a body (139) of a container (138); a fill actuator (7) comprising a filling valve assembly (29) in communication with the passageway (20) for selectively introducing thereinto propellant under pressure containing a substance in a suspension or solution; an exhaust actuator (10) comprising an exhaust valve assembly (48) in communication with the passageway (20) for selectively exhausting therefrom propellant under pressure containing substance; and a container-engaging body (16) in communication with the passageway (20) for receiving, in use, the head (141) of the body (139) of the container (138), the container-engaging body (16) including a chamber (116) of greater radial dimension than the valve stem (144) of the container (138) into which, in use, extends the valve stem (144) of the container (138) and a conduit (126) in communication with the chamber (116) for feeding a pressurised fluid thereto.
摘要翻译： 1。一种用于在压力下的推进剂中将物质尤其是药物物质的悬浮液或溶液引入容器的填充系统和用于将其填充到容器中的方法的填充设备，所述填充设备包括：主体（4），其包括 通道（20），用于在使用中与从容器（138）的主体（139）的头部（141）延伸的阀杆（144）连通; 填充致动器（7），其包括与通道（20）连通的填充阀组件（29），用于在压力下选择性地将含有悬浮液或溶液中的物质的推进剂引入其中; 排气致动器（10），其包括与所述通道（20）连通的排气阀组件（48），用于在含有压力的物质下选择性地将推进剂排出; 和容器接合体（16），其与通道（20）连通，用于在使用中接收容器（138）的主体（139）的头部（141），容器接合体（16）包括 具有比容器（138）的阀杆（144）更大的径向尺寸的腔室（116），在使用中，所述容器（138）的阀杆（144）延伸到所述腔室中，并且导管（126） 腔室（116）用于向其供应加压流体。
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2.发明公开Dispositif pour distribuer sous pression un produit, en particulier un produit moussant, et procédés de remplissage d'un récipient pour un tel dispositif 失效一种用于分配加压产品，特别是泡沫状的产品，和方法，用于填充这样的装置的容器。
公开(公告)号：EP0494004A1
公开(公告)日：1992-07-08
申请号：EP91403465.7
申请日：1991-12-19
申请人： L'OREAL
发明人： Yquel, Jean-Pierre
CPC分类号： B65D83/62 , B65B31/003
摘要： Le dispositif comprend un récipient (3) muni, en partie haute, d'une ouverture (4) sur laquelle est montée une valve de distribution (11), et une poche souple (9) disposée à l'intérieur dudit récipient (3) pour établir une séparation entre le produit (2) à distribuer et un moyen propulseur (14) propre à maintenir une pression interne suffisante pour la distribution du produit. Le produit actif (2) à distribuer est situé à l'intérieur de la poche souple (9) et la valve (11) est dépourvue de tube plongeur ; une quantité de moyen propulseur (14) est introduite dans le volume (10) du récipient (3) situé autour de la poche souple (9) ; la poche souple (9) est réalisée en une membrane suffisamment perméable pour permettre de maintenir un équilibre de la pression gazeuse du moyen propulseur (14) entre le volume (10) extérieur à la poche (9) et l'intérieur de cette poche (9).
摘要翻译： 该装置包括容器（3）的装备，在顶部，以在开口（4）上的所有其中，为了被安装在所述容器（3）内部设置有分配阀（11），和一个柔性袋（9），以形成 产品（2）之间的分离待分配和推进剂装置（14），其能够内部压力足够的用于产品的分配的维护的。 活性产品（2）要被分配位于柔性袋（9）和所述阀（11）的内部不具有柱塞管; 推进剂手段（14）的量被引入到位于周围的柔性袋（9）的容器（3）的体积（10）; 柔性袋（9）由膜产生的所有这是充分可渗透的，以允许所述袋（9），并且该袋的内部外部的推进剂装置的容积（10）之间的气体压力（14）的平衡的维护 （9）。
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公开(公告)号：EP1080014B1
公开(公告)日：2004-03-10
申请号：EP99925529.2
申请日：1999-04-21
申请人： AstraZeneca AB
CPC分类号： B65B31/10 , B65B31/047
摘要： A filling apparatus for, a filling system for and a method of introducing into a container a suspension or solution of a substance, in particular a pharmaceutical substance, in a propellant under pressure, the filling apparatus comprising: a main body (4) including a passageway (20) for communicating, in use, with a valve stem (144) extending from a head (141) of a body (139) of a container (138), the container (138) comprising a metering chamber (143) selectively communicatable by the valve stem (144) with the atmosphere and a storage chamber (140) defined by the body (139); a fill actuator (7) comprising a filling valve assembly (29) in communication with the passageway (20) for selectively introducing thereinto propellant under pressure containing a substance in a suspension or solution; an exhaust actuator (10) comprising an exhaust valve assembly (48) in communication with the passageway (20) for selectively exhausting therefrom propellant under pressure containing substance; and a container-engaging body (16) in communication with the passageway (20) for receiving, in use, the head (141) of the body (139) of the container (138), the container-engaging body (16) being movable relative to the main body (4) so as thereby to cause the valve stem (144) of the container (138) to be selectively positioned in an extended closed position, a depressed open position or an intermediate position therebetween, in which intermediate position the metering chamber (143 of the container (138) is closed to the atmosphere.
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公开(公告)号：EP0926070A1
公开(公告)日：1999-06-30
申请号：EP98500271.6
申请日：1998-12-15
申请人： Lima Merino, Marcelo
发明人： Lima Merino, Marcelo
IPC分类号： B65B31/10
CPC分类号： B65B31/10
摘要： The procedure entails the introduction through the mouth of the container of the base product and the propellant, made up of solid CO 2 at -75° to -85°C, and then, clamping the valve onto the container.
摘要翻译： 该程序需要通过基本产品的容器口和由固体CO 2在-75°至-85℃构成的推进剂引入，然后将阀夹紧在容器上。
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公开(公告)号：EP0574403B1
公开(公告)日：1996-06-12
申请号：EP92901658.2
申请日：1992-01-15
申请人： TURUNEN, Pentti
发明人： TURUNEN, Pentti
CPC分类号： B65D83/62 , B65B31/003
摘要： A system for using aerosols and aerosol packages. As taught by the invention, the system comprises a plurality of aerosol packages composed of a pressure-resistant shell, a resilient container within said shell, a press valve communicating with the space defined by said container, and propellant gas in the space between the container and the shell, and a filling apparatus for aerosol packages, with at least one liquid container, a nozzle suited to open the press valve of an aerosol package, and a force means for transferring liquid into the pressurized package.
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公开(公告)号：EP1073587A1
公开(公告)日：2001-02-07
申请号：EP99925528.4
申请日：1999-04-21
申请人： AstraZeneca AB
发明人： BRENNAN, John,Design By Design Co. , FLETCHER, Ian , METCALF, Stephen , PANCHOLI, Yogesh , SMITH, David,Flow Science Ltd.
CPC分类号： B65B31/003
摘要： A filling apparatus for, a filling system for and a method of introducing into a container a suspension or solution of a substance, in particular a pharmaceutical substance, in a propellant under pressure, the filling apparatus comprising: a main body (4) including a passageway (20) having an inlet opening (21) and first and second outlet openings (25, 22), the first outlet opening (25) communicating, in use, with a valve stem (144) extending from a head (141) of a body (139) of a container (138); a fill actuator (7) in communication with the inlet opening (21) of the passageway (20) comprising a filling valve assembly (29) for selectively introducing propellant under pressure containing a substance in a suspension or solution into the passageway (20); an exhaust actuator (10) in communication with the second outlet opening (22) of the passageway (20) comprising an exhaust valve assembly (48) for selectively exhausting propellant under pressure containing substance from the passageway (20) and including at least one exhaust gas conduit (84, 92, 93) having an outlet (86, 94, 95) configured so as, in use, to provide a flow of exhaust gas substantially aligned with a flow of propellant containing substance from the second outlet opening (22) of the passageway (20); and a container-engaging body (16) for receiving, in use, the head (141) of the body (139) of the container (138) which includes the valve stem (144).
摘要翻译： 1。一种用于在压力下的推进剂中将物质尤其是药物物质的悬浮液或溶液引入容器的填充系统和用于将其填充到容器中的方法的填充设备，所述填充设备包括：主体（4），其包括 具有入口开口（21）以及第一和第二出口开口（25,22）的第一出口开口（25），所述第一出口开口（25）在使用中与从所述入口开口的头部（141）延伸的阀杆（144） 容器（138）的主体（139）; 与通道（20）的入口开口（21）连通的填充致动器（7），其包括填充阀组件（29），用于选择性地将含有悬浮液或溶液中的物质的推进剂引入到通道（20）中; 与通道（20）的第二出口开口（22）连通的排气致动器（10），该排气致动器包括排气阀组件（48），用于在来自通道（20）的含压物质的压力下选择性地排出推进剂并且包括至少一个排气 具有出口（86,94,95）的气体导管（84,92,93），其构造成在使用中提供与来自第二出口开口（22）的含推进剂物质流大致对齐的废气流， （20）的通道; 和容器接合体（16），用于在使用中接收容器（138）的包括阀杆（144）的主体（139）的头部（141）。
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8.发明公开Method of generating aerosol with environment-safeguarding liquefied gas as propellant 失效一种用于与环境友好的液体气体作为推进剂产生气雾剂的方法。
公开(公告)号：EP0671218A3
公开(公告)日：1997-10-01
申请号：EP95301391.9
申请日：1995-03-03
发明人： Takahashi, Masashi , Ozaki, Yoji , Fumino, Ichiro
摘要： To permit aerosol generation apart from the restriction of rules and regulations, the aerosol generation being easy, ready, free from adverse effects on the environment and such that a mother substance is sprayed uniformly. Mother substanse (4) is dissolved uniformly in environment-safeguarding liquefied gas (5) by sealing these substances in a small size, high pressure gas cartridge (1) of 100 cc or below. The cartridge (1) is opened to spray the mother substance (4) together with the environment-safeguarding liquefied gas by making use of the pressure of gasification of the liquefied gas (5). The liquefied gas is liquefied carbon dioxide or nitrogen suboxide gas. The mother substance (4) is charged directly if it is soluble to the phase of the environment-safeguarding liquefied gas (5). If the mother substance is a physically insoluble chemical substance, it is dissolved in a solvent, a fat, etc. using a dispenser before charging. If the mother substance is powder, it is commuted to 0.5 µm or below for suspension. The small size, high pressure gas cartridge (1) may be sealed by mounting a constant quantity valve in an opening (6) of the small size, high pressure gas cartridge.
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9.发明授权Verfahren zum Befüllen eines Behälters mit Kohlendioxid (CO2) und Kohlendioxid (CO2)-enthaltender Behälter 有权一种用于填充容器的二氧化碳（CO 2）和二氧化碳（CO 2）的含容器的方法
公开(公告)号：EP1686062B1
公开(公告)日：2009-09-02
申请号：EP05022395.7
申请日：2005-10-13
发明人： Czech, Joachim , Menzel, Ulrich
CPC分类号： B65D83/752 , B65B31/10
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公开(公告)号：EP2007629A1
公开(公告)日：2008-12-31
申请号：EP07735527.9
申请日：2007-04-17
发明人： SMITH, Scott, Edward
CPC分类号： B65B31/003 , B65B31/10
摘要： A method of filling a container with a product. The container may be pressurized. An outer container (12) is provided. Product and/or propellant is disposed in the outer container. An inner container (16) is disposed in the outer container. The inner container expands upon the insertion of product and/or propellant therein. This expansion provides for pressurization of the contents of the outer container, which pressurization is useful for dispensing the contents of the inner container, and/or outer container. This method may be performed in a variety of sequences.
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