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公开(公告)号：EP1427718B1
公开(公告)日：2006-11-15
申请号：EP02765012.6
申请日：2002-09-05
申请人： AstraZeneca AB
IPC分类号： C07D337/08 , C07D409/12 , A61K31/38 , A61P3/06
CPC分类号： C07D409/12 , C07D337/08
摘要： The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
摘要翻译： 本发明涉及式（I）的化合物，其中可变基团如上定义; 其药学上可接受的盐，溶剂化物，这些盐的溶剂化物和前药以及它们作为回肠胆汁酸转运（IBAT）抑制剂用于治疗高脂血症的用途。 还描述了它们的制造方法和含有它们的药物组合物。
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公开(公告)号：EP1430040A1
公开(公告)日：2004-06-23
申请号：EP02755285.0
申请日：2002-08-30
申请人： Astrazeneca AB
发明人： STARKE, Ingemar , DAHLSTROM, Mikael, Ulf, Johan , BLOMBERG, David , ALENFALK, Suzanne , NORDBERG, Peter , WALLBERG, Andreas, Christer , BOSTROM, Stig, Jonas
IPC分类号： C07D281/10 , C07D417/12 , A61K31/554 , A61P3/06
CPC分类号： C07D417/12 , C07D281/10
摘要： The present invention relates to compounds of formula (I), wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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3.发明公开DIPHENYLAZETIDINONE DERIVATIVES FOR TREATING DISORDERS OF THE LIPID METABOLISM 审中-公开Diphenylazetidinone衍生物为血脂异常代谢的治疗
公开(公告)号：EP1521742A1
公开(公告)日：2005-04-13
申请号：EP03762763.5
申请日：2003-07-01
申请人： AstraZeneca AB
发明人： STARKE, Ingemar , DAHLSTROM, Mikael, Ulf, Johan , LINDQVIST, Ann-Margret , NORDBERG, Mats, Peter , SKJARET, Tore , LEMURELL, Malin, Anita
IPC分类号： C07D205/08 , C07D409/12 , A61K31/397 , A61P3/06 , A61P9/10
CPC分类号： C07D409/12 , C07D205/08
摘要： Compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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公开(公告)号：EP1427718A1
公开(公告)日：2004-06-16
申请号：EP02765012.6
申请日：2002-09-05
申请人： AstraZeneca AB
IPC分类号： C07D337/08 , C07D409/12 , A61K31/38 , A61P3/06
CPC分类号： C07D409/12 , C07D337/08
摘要： The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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5.发明公开AMINE SALTS OF (-)-2- ¬2-(4-HYDROXYPHENYL)ETHYL|-THIO -3-¬4-(2- 4-¬(METHYLSULFONYL)OXY|PHENOXY ETHYL)PHENYL|PROPANOIC ACID AND THEIR USE IN MEDICINE. 审中-公开的胺盐（ - ） - 2 - [ '2-（4-羟基苯基）乙基硫代] -3- '4-（2- [4' - （甲磺酰）氧基苯氧基〕乙基）苯基丙酸和它们在医学。
公开(公告)号：EP1638930A1
公开(公告)日：2006-03-29
申请号：EP04736922.8
申请日：2004-06-16
申请人： AstraZeneca AB
发明人： AHLQVIST, Matti , DAHLSTROM, Mikael, Ulf, Johan , OHLSSON, Bengt , STOREY, Richard, Anthony AstraZeneca,Charter Way , TAYLOR, Nigel, Philip AstraZeneca , WOODS, Rebecca AstraZeneca
IPC分类号： C07C323/56 , A61K31/192
CPC分类号： C07C323/56
摘要： A tert-butylamine salt, a piperazine salt, a choline salt, a tris(hydroxymethyl)methylamine salt, a lysine salt or an adamantylamine salt of (-)-2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4-(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoic acid processes for their preparation, their use in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance and other manifestations of the metabolic syndrome, and pharmaceutical compositions containing them.
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公开(公告)号：EP1597245A1
公开(公告)日：2005-11-23
申请号：EP04713573.6
申请日：2004-02-23
申请人： AstraZeneca AB
发明人： STARKE, Ingemar , ALENFALK, Suzanne , NORDBERG, Mats, Peter , DAHLSTROM, Mikael, Ulf, Johan , BOSTROM, Stig, Jonas , LEMURELL, Malin, Anita , WALLBERG, Andreas, Christer
IPC分类号： C07D281/10 , C07D337/08 , A61K31/38 , A61K31/554 , A61P3/06
CPC分类号： C07D281/10 , C07D337/08
摘要： Compounds of formula: (I) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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7.发明授权BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA 有权苯并硫氮杂和具有锁定对酸转运在胆囊GEARS用于治疗高脂血症衍生物苯并硫
公开(公告)号：EP1427423B1
公开(公告)日：2006-12-27
申请号：EP02765013.4
申请日：2002-09-05
申请人： AstraZeneca AB
发明人： STARKE, Ingemar , DAHLSTROM, Mikael, Ulf, Johan , BLOMBERG, David , ALENFALK, Suzanne , SKJARET, Tore , LEMURELL, Malin
IPC分类号： A61K31/554 , C07D285/36 , A61P3/06 , C07D281/02 , C07K5/065 , C07K5/087 , A61K38/05 , A61K38/06
CPC分类号： C07D417/12 , C07D285/36
摘要： The present invention relates to compounds of formula (I) wherein R v , R 1 , R 2 , R x , R y , M, R z , v, R 3 , R 4 , R 5 and R 6 are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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8.发明公开PEPTIDE DERIVATIVES COMPRISING THIAZEPINE GROUP FOR THE TREATMENT OF HYPERLIPIDEMIC CONDITIONS 有权与治疗高脂血症的THIAZEPINGRUPPE肽衍生物
公开(公告)号：EP1515984A1
公开(公告)日：2005-03-23
申请号：EP03732693.1
申请日：2003-06-10
申请人： Astrazeneca AB
发明人： STARKE, Ingemar , DAHLSTROM, Mikael, Ulf, Johan , ALENFALK, Suzanne , SKJARET, Tore , LEMURELL, Malin
CPC分类号： C07K5/06078 , A61K38/00
摘要： The present invention relates to compounds of formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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9.发明公开BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA 有权苯并硫氮杂和具有锁定对酸转运在胆囊GEARS用于治疗高脂血症衍生物苯并硫
公开(公告)号：EP1427423A1
公开(公告)日：2004-06-16
申请号：EP02765013.4
申请日：2002-09-05
申请人： AstraZeneca AB
发明人： STARKE, Ingemar , DAHLSTROM, Mikael, Ulf, Johan , BLOMBERG, David , ALENFALK, Suzanne , SKJARET, Tore , LEMURELL, Malin
IPC分类号： A61K31/554 , C07D285/36 , A61P3/06 , C07D281/02 , C07K5/065 , C07K5/087 , A61K38/05 , A61K38/06
CPC分类号： C07D417/12 , C07D285/36
摘要： The present invention relates to compounds of formula (I) wherein R v , R 1 , R 2 , R x , R y , M, R z , v, R 3 , R 4 , R 5 and R 6 are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.
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10.发明授权BENZOTHIAZEPINE AND BENZOTHIADIAZEPINE DERIVATIVES WITH ILEAL BILE ACID TRANSPORT (IBAT) INHIBITORY ACTIVITY FOR THE TREATMENT HYPERLIPIDAEMIA 有权苯并噻嗪和苯并二氮杂衍生物的回肠胆酸运输（IBAT）抑制活性治疗高脂血症
公开(公告)号：EP1427423B9
公开(公告)日：2017-12-20
申请号：EP02765013.4
申请日：2002-09-05
申请人： AstraZeneca AB
发明人： STARKE, Ingemar , DAHLSTROM, Mikael, Ulf, Johan , BLOMBERG, David , ALENFALK, Suzanne , SKJARET, Tore , LEMURELL, Malin
IPC分类号： A61K31/554 , C07D285/36 , A61P3/06 , C07D281/02 , C07K5/065 , C07K5/087 , A61K38/05 , A61K38/06
CPC分类号： C07D417/12 , C07D285/36
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