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1.1H-PYRAZOLO[3,4-D]PYRIMIDINE-4,6-DIONES AS T-CELL PROLIFERATION INHIBITORS 失效
标题翻译: 1H-吡唑并[3,4-D]嘧啶类-4,6-二酮作为T细胞的产生抑制剂公开(公告)号:EP0975636B1
公开(公告)日:2003-07-23
申请号:EP98917859.5
申请日:1998-04-07
申请人: AstraZeneca AB
发明人: CHESHIRE, David , COOPER, Martin , DONALD, David , THORNE, Philip
IPC分类号: C07D487/04 , A61K31/505 , A61K31/415
CPC分类号: C07D487/04 , A61K31/506
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2.PYRROLO[3,4-d]PYRIMIDINONE DERIVATIVES AND THEIR USE AS IMMUNOSUPPRESSANTS 失效
标题翻译: 吡咯并[3,4-D]嘧啶酮衍生物及其作为免疫抑制剂公开(公告)号:EP0946562B1
公开(公告)日:2002-03-27
申请号:EP97952146.5
申请日:1997-12-18
申请人: AstraZeneca AB
发明人: COOPER, Martin , CHESHIRE, David , DONALD, David , FURBER, Mark , PERRY, Matthew , HARRISON, Richard , TOMKINSON, Nicholas
IPC分类号: C07D487/04
CPC分类号: C07D487/04
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公开(公告)号:EP0991653B1
公开(公告)日:2002-10-16
申请号:EP98924705.1
申请日:1998-05-18
申请人: AstraZeneca AB
发明人: CHESHIRE, David , COOKE, Andrew , COOPER, Martin , DONALD, David , FURBER, Mark , PERRY, Matthew , THORNE, Philip
IPC分类号: C07D495/04 , A61K31/505
CPC分类号: C07D495/04
摘要: A compound of formula (I), wherein R, R?1, R2 and R3¿ have the meanings given in the description. Compound (I) is useful in the (prophylactic) treatment of autoimmune, inflammatory, proliferative and hyperproliferative diseases and immunologically-mediated diseases including rejection of transplanted organs or tissues and Acquired Immunodeficiency Syndrome (AIDS).
摘要翻译: 式(I)化合物,其中R,R 1,R 2和R 3具有在说明书中给出的含义。 化合物(I)可用于(预防性)治疗自身免疫性疾病,炎症性疾病,增殖性疾病和过度增殖性疾病以及免疫介导的疾病,包括移植器官或组织的排斥和获得性免疫缺陷综合征(AIDS)。
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