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1.发明公开
公开(公告)号：EP2231597A1
公开(公告)日：2010-09-29
申请号：EP08860193.5
申请日：2008-12-10
申请人： AstraZeneca AB
发明人： CAGE, Peter, Alan , FURBER, Mark , LUCKHURST, Christopher, Andrew , SANGANEE, Hitesh, Jayantilal , STEIN, Linda, Anne
IPC分类号： C07D205/04 , C07D207/16 , C07D211/60 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/45 , A61K31/4015 , A61P11/06 , A61P11/08 , A61P37/08
CPC分类号： C07D417/12 , C07D205/04 , C07D207/16 , C07D211/60 , C07D211/62 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention provides compounds of formula (I) in which n, y, X1, X2, A, B, R1, R2, R3, R4 and R5 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use as dipeptidyl peptidase I (DPPI) inhibitors.
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2.发明公开PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开哌啶衍生物，其制备方法，其作为治疗剂和包含它们的药物组合物的用途
公开(公告)号：EP1994002A1
公开(公告)日：2008-11-26
申请号：EP07716032.3
申请日：2007-03-06
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/4535 , A61K31/454 , A61K31/455 , A61K31/4709 , A61K31/506 , A61K31/517 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/12 , C07D409/12
CPC分类号： C07D211/58 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a compound of a formula (I): [Chemical formula should be inserted here. Please see paper copy] wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.
摘要翻译： 本发明提供了式（I）的化合物：[化学式应插入此处。 请参阅文件副本]其中变量在此处定义; 涉及制备这种化合物的方法; 并涉及这种化合物在治疗趋化因子（如CCR3）介导的疾病状态中的用途。
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公开(公告)号：EP1240132B1
公开(公告)日：2004-04-07
申请号：EP00983632.1
申请日：2000-12-01
申请人： AstraZeneca AB
IPC分类号： C07C235/46 , C07C237/30 , C07C233/65 , C07C233/01 , C07C233/88 , A61K31/166 , A61K31/167 , A61P37/00
CPC分类号： C07D233/64 , C07C235/46 , C07C237/30 , C07C317/18 , C07C317/28 , C07C323/12 , C07C323/25 , C07C2603/74 , C07D231/12 , C07D233/56 , C07D249/08
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4.发明公开PIPERIDINE DERIVATIVES, THEIR PROCESS FOR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. 审中-公开哌啶衍生物，其制备方法，其作为治疗剂和包含它们的药物组合物的用途。
公开(公告)号：EP1996551A2
公开(公告)日：2008-12-03
申请号：EP07716034.9
申请日：2007-03-03
申请人： AstraZeneca AB
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/454 , A61K31/455 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D413/12 , C07D413/14
CPC分类号： C07D211/58 , C07D413/12 , C07D413/14
摘要： The present invention provides a compound of a formula (I): [Chemical formula should be inserted here. Please see paper copy] wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.
摘要翻译： 本发明提供了式（I）的化合物：[化学式应插入此处。 请参阅文件副本]其中变量在此处定义; 涉及制备这种化合物的方法; 并涉及这种化合物在治疗趋化因子（如CCR3）介导的疾病状态中的用途。
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5.发明授权PYRROLO[3,4-d]PYRIMIDINONE DERIVATIVES AND THEIR USE AS IMMUNOSUPPRESSANTS 失效吡咯并[3,4-D]嘧啶酮衍生物及其作为免疫抑制剂
公开(公告)号：EP0946562B1
公开(公告)日：2002-03-27
申请号：EP97952146.5
申请日：1997-12-18
申请人： AstraZeneca AB
发明人： COOPER, Martin , CHESHIRE, David , DONALD, David , FURBER, Mark , PERRY, Matthew , HARRISON, Richard , TOMKINSON, Nicholas
IPC分类号： C07D487/04
CPC分类号： C07D487/04
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6.发明公开PIPERIDINE DERIVATIVES USEFUL FOR TREATING OSTEOARTHRITIS AND OSTEOARTROSIS 审中-公开哌啶衍生物用于治疗骨关节炎和骨关节炎的治疗
公开(公告)号：EP2010175A1
公开(公告)日：2009-01-07
申请号：EP07747987.1
申请日：2007-04-04
申请人： AstraZeneca AB
发明人： CAGE, Peter , FURBER, Mark , KHAN, Zara , NEEDHAM, Maurice , NEWHAM, Peter
IPC分类号： A61K31/4465 , A61K31/454 , A61P19/02 , C07D417/12
CPC分类号： C07D417/12 , A61K31/4465 , A61K31/454
摘要： Use of a compound of formula (I): [Chemical formula should be inserted here. Please see paper copy] wherein: R1 is phenyl optionally substituted by halogen, cyano, C1-4#191 alkyl or C1-4#191 haloalkyl; R2 is hydrogen, C1-6#191 alkyl or C3-6#191 cycloalkyl; and R3 is a group having an NH or OH that has a calculated or measured pKa of 1.0 to 8.0; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use in the treatment of osteoarthritis or osteoarthrosis. The invention also concerns the benzenesulfonate salt of N-{3-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-2-hydroxypropyl}-2,3-dihydro-2-oxo-4-(trifluoromethyl)-5-thiazolecarboxamide, a process for making it, and its use in therapy (for example in treating CCR3 mediated disease states).
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7.发明公开
公开(公告)号：EP1994003A1
公开(公告)日：2008-11-26
申请号：EP07716033.1
申请日：2007-03-06
申请人： AstraZeneca AB
发明人： CAGE, Peter , FURBER, Mark , PERRY, Matthew , SPRINGTHORPE, Brian
IPC分类号： C07D211/58 , A61K31/4468 , A61K31/455 , A61K31/4709 , A61P11/00 , A61P11/06 , A61P29/00 , A61P35/00 , A61P37/00 , C07D401/12
CPC分类号： C07D211/58 , C07D401/12
摘要： The present invention provides a compound of a formula (I) wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.
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公开(公告)号：EP1240132A1
公开(公告)日：2002-09-18
申请号：EP00983632.1
申请日：2000-12-01
申请人： AstraZeneca AB
IPC分类号： C07C235/46 , C07C237/30 , C07C233/65 , C07C233/01 , C07C233/88 , A61K31/166 , A61K31/167 , A61P37/00
CPC分类号： C07D233/64 , C07C235/46 , C07C237/30 , C07C317/18 , C07C317/28 , C07C323/12 , C07C323/25 , C07C2603/74 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The invention provides adamantane derivatives of formula (I), a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
摘要翻译： 本发明提供式（I）的金刚烷衍生物，其制备方法，含有它们的药物组合物，制备药物组合物的方法及其在治疗中的用途。
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公开(公告)号：EP0991653B1
公开(公告)日：2002-10-16
申请号：EP98924705.1
申请日：1998-05-18
申请人： AstraZeneca AB
发明人： CHESHIRE, David , COOKE, Andrew , COOPER, Martin , DONALD, David , FURBER, Mark , PERRY, Matthew , THORNE, Philip
IPC分类号： C07D495/04 , A61K31/505
CPC分类号： C07D495/04
摘要： A compound of formula (I), wherein R, R?1, R2 and R3¿ have the meanings given in the description. Compound (I) is useful in the (prophylactic) treatment of autoimmune, inflammatory, proliferative and hyperproliferative diseases and immunologically-mediated diseases including rejection of transplanted organs or tissues and Acquired Immunodeficiency Syndrome (AIDS).
摘要翻译： 式（I）化合物，其中R，R 1，R 2和R 3具有在说明书中给出的含义。 化合物（I）可用于（预防性）治疗自身免疫性疾病，炎症性疾病，增殖性疾病和过度增殖性疾病以及免疫介导的疾病，包括移植器官或组织的排斥和获得性免疫缺陷综合征（AIDS）。
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10.发明公开SUBSTITUTED PHENYL COMPOUNDS WITH IMMUNOSUPPRESSING ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开具有免疫抑制作用和PHARMAZUTISCHE组合物您是否提供取代苯基
公开(公告)号：EP1185522A1
公开(公告)日：2002-03-13
申请号：EP00931406.3
申请日：2000-05-22
申请人： AstraZeneca AB
发明人： FURBER, Mark , LUKER, Timothy Jon , MORTIMORE, Michael Paul,Vertex Pharm.(Europe)Ltd. , THORNE, Philip , MEGHANI, Premji
IPC分类号： C07D295/12 , C07D295/08 , C07D295/18 , C07D207/09 , A61K31/40 , A61K31/445 , A61K31/495 , A61P37/06 , C07D211/46 , C07D207/14 , C07D207/08 , C07D239/42 , C07D233/61 , C07C237/34 , C07C237/20
CPC分类号： C07D207/08 , C07C237/20 , C07C237/34 , C07D207/09 , C07D207/14 , C07D211/46 , C07D231/12 , C07D233/56 , C07D239/42 , C07D249/08 , C07D295/088 , C07D295/135 , C07D295/185
摘要： The invention provides substituted phenyl compounds of general formula (I) wherein R1, T, U and Ar are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their use in therapy.
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