公开(公告)号：EP2303266A1

公开(公告)日：2011-04-06

申请号：EP09766952.7

申请日：2009-06-18

申请人： AstraZeneca AB

发明人： CONNOLLY, Stephen ,  FISHER, Adrian ,  HUMPHRIES, Alexander ,  WATTS, Andrew James ,  WILEY, Katherine Elisabeth

IPC分类号： A61K31/428 ,  A61P11/06 ,  A61P11/08

CPC分类号： A61K45/06 ,  A61K31/428 ,  A61K2300/00

摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is N-Cyclohexyl-Λ/
3 -[2-(3-fluorophenyl)ethyl]-Λ/-(2-{[2-(4- hydroxy-2-oxo-2,3-dihydro- 1,3-benzothiazol-7-yl)ethyl]amino} ethyl)-β-alaninamide or a salt thereof, and a second active ingredient selected from: a non-steroidal Glucocorticoid Receptor (GR Receptor) Agonist; an antioxidant; a CCRl antagonist; a chemokine antagonist (not CCRl); a corticosteroid; a CRTh2 antagonist; a DPI antagonist; an Histone Deacetylase Inducer; an IKK2 inhibitor; a COX inhibitor; a lipoxygenase inhibitor; a leukotriene receptor antagonist; an MPO inhibitor; a muscarinic antagonist; a p38 inhibitor; a PDE inhibitor; a PPARγ agonist; a protease inhibitor; a Statin; a thromboxane antagonist; a vasodilator; or, an ENAC blocker (Epithelial Sodium-channel blocker); and its use in the treatment of respiratory disease (for example chronic obstructive pulmonary disease (COPD) or asthma); to certain salts of A/-Cyclohexyl-N
3 -[2-(3-fluorophenyl)ethyl]- N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihydro-l,3-benzothiazol-7-yl)ethyl]amino}ethyl)-β- alaninamide and to an intermediate useful in the manufacture of this pharmaceutically active substance and salts thereof.

公开(公告)号：EP2094646A1

公开(公告)日：2009-09-02

申请号：EP07848596.8

申请日：2007-12-19

申请人： AstraZeneca AB

发明人： ALCARAZ, Lilian ,  BONNERT, Roger Victor ,  CONNOLLY, Stephen ,  COOK, Anthony, Ronald ,  FISHER, Adrian ,  HUMPHRIES, Alexander ,  RAUBO, Piotr

IPC分类号： C07C237/08 ,  C07C237/10 ,  C07D209/34 ,  C07D265/36 ,  C07D215/227 ,  A61K31/4704 ,  A61K31/536 ,  A61P11/00 ,  A61P29/00 ,  C07C233/01

CPC分类号： C07D265/36 ,  C07C233/43 ,  C07C2601/14 ,  C07D209/34 ,  C07D215/26 ,  C07D409/12 ,  C07D413/12

摘要： The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and E are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明提供式（I）化合物，其中k，Ar，R2，R3，R4，R5，R4'，R5'，R6，R7，A，D，m和E如说明书中所定义， 其制剂，含有它们的药物组合物及其在治疗中的用途。

公开(公告)号：EP2121642B1

公开(公告)日：2011-07-27

申请号：EP07848598.4

申请日：2007-12-19

申请人： AstraZeneca AB

发明人： CONNOLLY, Stephen ,  HUMPHRIES, Alexander ,  MEGHANI, Premji

IPC分类号： C07D285/14 ,  C07D417/12

CPC分类号： C07D277/14 ,  C07D417/12

摘要： The present invention provides compounds of formula (I) (A chemical formula should be inserted here - please see paper copy enclosed herewith) wherein Ra, Rb, R1, R2, R3, R4, R5, R6 and R29 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

公开(公告)号：EP2121642A1

公开(公告)日：2009-11-25

申请号：EP07848598.4

申请日：2007-12-19

申请人： AstraZeneca AB

发明人： CONNOLLY, Stephen ,  HUMPHRIES, Alexander ,  MEGHANI, Premji

IPC分类号： C07D285/14 ,  C07D417/12

CPC分类号： C07D277/14 ,  C07D417/12

摘要： The present invention provides compounds of formula (I) (A chemical formula should be inserted here - please see paper copy enclosed herewith) wherein Ra, Rb, R1, R2, R3, R4, R5, R6 and R29 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

摘要翻译： 本发明提供了式（I）化合物（这里应该插入化学式 - 请参阅随附的纸质副本），其中Ra，Rb，R1，R2，R3，R4，R5，R6和R29如说明书中所定义 ，它们的制备方法，含有它们的药物组合物以及它们在治疗中的用途。